METHYL 1-BOC-4-PIPERIDINEACETATE
- CAS No.
- 175213-46-4
- Chemical Name:
- METHYL 1-BOC-4-PIPERIDINEACETATE
- Synonyms
- Methyl-1-Bocpiperidine-4-acetate;tert-butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate;METHYL 1-BOC-4-PIPERIDINEACETATE;Methyl N-Boc-4-piperidineacetate;Methyl N-BOC-piperidine-4-acetate;Methyl 1-N-Boc-4-piperidineacetate;1-Boc-4-Piperidine acetate methyl ester;N-BOC-4-PIPERIDINEACETIC ACID METHYL ESTER;1-Boc-4-Piperidine acetic acid methyl ester;Methyl 1-Boc-4-piperidine acetate - [M12265]
- CBNumber:
- CB2491392
- Molecular Formula:
- C13H23NO4
- Molecular Weight:
- 257.33
- MDL Number:
- MFCD01632529
- MOL File:
- 175213-46-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| METHYL 1-N-BOC-4-PIPERIDINEACETATE 97% | 64151 | 25G | $29 |
| METHYL 1-N-BOC-4-PIPERIDINEACETATE 97% | 64151 | 100G | $114 |
| Methyl (piperidin-4-yl)acetate, N-BOC protected 98% | OR51981 | 5g | $21 |
| Methyl (piperidin-4-yl)acetate, N-BOC protected 98% | OR51981 | 25g | $40 |
| Methyl (piperidin-4-yl)acetate, N-BOC protected 98% | OR51981 | 100g | $153 |
| More product size | |||
| Boiling point | 323.1±15.0 °C(Predicted) |
|---|---|
| Density | 1.062±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | -1.88±0.40(Predicted) |
| Appearance | Colorless to light yellow Liquid |
| CAS DataBase Reference | 175213-46-4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P271-P261-P280 |
| HS Code | 29333990 |
METHYL 1-BOC-4-PIPERIDINEACETATE price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 64151 | METHYL 1-N-BOC-4-PIPERIDINEACETATE 97% | 175213-46-4 | 25G | $29 | 2026-04-30 | Buy |
| AstaTech | 64151 | METHYL 1-N-BOC-4-PIPERIDINEACETATE 97% | 175213-46-4 | 100G | $114 | 2026-04-30 | Buy |
| Apolloscientific | OR51981 | Methyl (piperidin-4-yl)acetate, N-BOC protected 98% | 175213-46-4 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR51981 | Methyl (piperidin-4-yl)acetate, N-BOC protected 98% | 175213-46-4 | 25g | $40 | 2026-06-04 | Buy |
| Apolloscientific | OR51981 | Methyl (piperidin-4-yl)acetate, N-BOC protected 98% | 175213-46-4 | 100g | $153 | 2026-06-04 | Buy |
METHYL 1-BOC-4-PIPERIDINEACETATE Chemical Properties,Uses,Production
Chemical Properties
White powder
Uses
Methyl 1-Boc-4-piperidineacetate is used as a pharmaceutical intermediate. It can be used in the preparation of intranasal pharmaceutical compositions of CGRP inhibitors for the treatment of migraine.
Synthesis
169206-65-9
175213-46-4
General procedure for the synthesis of methyl N-Boc-4-piperidineacetate from tert-butyl 4-(2-methoxy-2-oxoethylidene)piperidine-1-carboxylate: 1-tert-butoxycarbonyl-4-[(methoxycarbonyl)methylidene]piperidine (875 mg) was dissolved in ethanol (10 mL), to which 10% of palladium-carbon catalyst (~50% water content, 730 mg) was added. The reaction mixture was subjected to catalytic hydrogenation at room temperature and at atmospheric pressure for 3 days. Upon completion of the reaction, the catalyst was removed by filtration and the solvent was subsequently removed by distillation under reduced pressure to afford the target product methyl N-Boc-4-piperidineacetate (871 mg, 99% yield). The product was characterized by 1H-NMR (CDCl3): δ 1.16 (2H, m), 1.45 (9H, s), 1.65 (2H, m), 1.93 (1H, m), 2.25 (2H, d, J = 6.8 Hz), 2.72 (2H, br), 3.68 (3H, s), 4.08 (2H, br). Mass spectrometry (FAB) analysis showed m/z: 258 (M + H)+.
References
[1] Patent: EP1104754, 2001, A1
[2] Patent: EP1577302, 2005, A1. Location in patent: Page/Page column 121-122
[3] Patent: US2006/94707, 2006, A1. Location in patent: Page/Page column 43
[4] Patent: US2007/259850, 2007, A1. Location in patent: Page/Page column 79
[5] Patent: WO2011/123232, 2011, A1. Location in patent: Page/Page column 9
METHYL 1-BOC-4-PIPERIDINEACETATE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16512 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9542 | 58 |
| Kindchem(Nanjing)Co.,Ltd | +86-025-025-85281586 +8618651653755 | sales@kindchem.cn | China | 1226 | 58 |
View Lastest Price from METHYL 1-BOC-4-PIPERIDINEACETATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-17 | tert-butyl 4-(2-methoxy-2-oxo-ethyl)piperidine-1-carboxylate
175213-46-4
|
$2.20-8.80 | 1KG | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | ||
 |
2019-07-06 | METHYL 1-BOC-4-PIPERIDINEACETATE
175213-46-4
|
$1.00 | 1KG | 98% | 1ton | Career Henan Chemical Co |
-
- tert-butyl 4-(2-methoxy-2-oxo-ethyl)piperidine-1-carboxylate
175213-46-4
- $2.20-8.80
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- METHYL 1-BOC-4-PIPERIDINEACETATE
175213-46-4
- $1.00
- 98%
- Career Henan Chemical Co
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