D-(+)-NEOPTERIN
- CAS No.
- 2009-64-5
- Chemical Name:
- D-(+)-NEOPTERIN
- Synonyms
- NEOPTERIN;D-Neopterin [D-erythro-Neopterin];(+)-NEOPTERIN;D-erythro-Form;2-Amino-6-((1S;D-(+)-NEOPTERIN;Neopterin (7CI);D(+)-Neopterin,99%;D-ERYTHRO-NEOPTERIN;D-(PLUS)-NEOPTERINE
- CBNumber:
- CB2734079
- Molecular Formula:
- C9H11N5O4
- Molecular Weight:
- 253.21
- MDL Number:
- MFCD00042801
- MOL File:
- 2009-64-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| D-(+)-Neopterin ≥97.5% (sum of enantiomers, HPLC) | N3386 | 10mg | $83.4 |
| D-(+)-Neopterin ≥97.5% (sum of enantiomers, HPLC) | N3386 | 25mg | $155 |
| D-Neopterin ≥98% | 12057 | 10mg | $40 |
| D-Neopterin ≥98% | 12057 | 25mg | $75 |
| D-Neopterin ≥98% | 12057 | 50mg | $129 |
| Melting point | >232°C (dec.) |
|---|---|
| alpha | D25 +45 ± 3° (c = 0.3 in 0.1N HCl) |
| Boiling point | 396.41°C (rough estimate) |
| Density | 1.3957 (rough estimate) |
| refractive index | 1.7610 (estimate) |
| storage temp. | 2-8°C |
| solubility | Aqueous Acid (Slightly, Sonicated), Aqueous Base (Slightly) |
| form | Off-white to yellow solid. |
| pka | 12.60±0.20(Predicted) |
| color | Light Orange to Light Brown |
| Merck | 13,6490 |
| BRN | 89070 |
| Stability | Hygroscopic |
| InChI | InChI=1S/C9H11N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h1,4,6,15-17H,2H2,(H3,10,11,13,14,18)/t4-,6+/m1/s1 |
| InChIKey | BMQYVXCPAOLZOK-XINAWCOVSA-N |
| SMILES | N1C2C(=NC([C@H](O)[C@H](O)CO)=CN=2)C(=O)NC=1N |
| FDA UNII | 9PLD60N7SO |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 23 | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
D-(+)-NEOPTERIN price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N3386 | D-(+)-Neopterin ≥97.5% (sum of enantiomers, HPLC) | 2009-64-5 | 10mg | $83.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | N3386 | D-(+)-Neopterin ≥97.5% (sum of enantiomers, HPLC) | 2009-64-5 | 25mg | $155 | 2026-04-30 | Buy |
| Cayman Chemical | 12057 | D-Neopterin ≥98% | 2009-64-5 | 10mg | $40 | 2026-04-30 | Buy |
| Cayman Chemical | 12057 | D-Neopterin ≥98% | 2009-64-5 | 25mg | $75 | 2026-04-30 | Buy |
| Cayman Chemical | 12057 | D-Neopterin ≥98% | 2009-64-5 | 50mg | $129 | 2026-04-30 | Buy |
D-(+)-NEOPTERIN Chemical Properties,Uses,Production
Description
Neopterin is a pyrazino-
Chemical Properties
off-white to yellow solid
Uses
Precursor in the biosynthesis of Biopterin. First isolated from the pupae of bees.
Uses
D-(+)-Neopterin has been used as a NADPH oxidase inhibitor while assessing the ability of NADPH oxidases in breast cancer cells to produce reactive oxygen species (ROS). [NADPH= nicotinamide adenine dinucleotide phosphate]
General Description
D-(+)-Neopterin is a pteridine derivative, naturally found in Dictyostelium discoideum. It is found in significant amounts in the urine of cancer patients.
Biochem/physiol Actions
Pterin cofactor; precursor of BH4 (tetrahydrobiopterin).
storage
Store at -20°C
Purification Methods
Purification is as for biopterin. Also purify it on a Dowex-1 x 8 (formate form) column and elute with 0.03M ammonium formate buffer pH 8.0 then pH 7.2. The fluorescent neopterin fraction is evaporated under reduced pressure, leaving neopterin and ammonium formate (the latter sublimes out at high vacuum) behind. Stir the residue for 24hours with EtOH, collect the solid and recrystallise it from H2O. [Viscontini et al. Helv Chim Acta 53 1202 1970, cf Wachter et al. Eds Neopterin W de Gruyter, Berlin 1992, ISBN 9783110117905, Beilstein 26 IV 4038.]
References
[1] RONG-SEN SHEN Yixian Z Aftab Alam. Inhibition of GTP cyclohydrolase I by pterins[J]. Biochimica et biophysica acta. General subjects, 1988, 965 1: Pages 9-15. DOI: 10.1016/0304-4165(88)90144-4
[2] C HUBER. Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma.[J]. Journal of Experimental Medicine, 1984, 160 1: 310-316. DOI: 10.1084/jem.160.1.310
D-(+)-NEOPTERIN Preparation Products And Raw materials
Raw materials
Preparation Products
D-(+)-NEOPTERIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Creative Enzymes | 1-516-855-7709 | info@creative-enzymes.com | United States | 8748 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9996 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15082 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Guangzhou Ku Wei Biological Technology Co., Ltd | 15013362837 | yxusmith@aliyun.com | China | 6 | 52 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40228 | 62 |
