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ChemicalBook >> CAS DataBase List >>ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE

ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE

CAS No.
72850-52-3
Chemical Name:
ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE
Synonyms
Ethyl 2-chloro-4-(trifluoroMethyl)thiazole-5-carboxylate;ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE;2-chloro-4-trifluoromethyl-thiazol-5-carboxylic acid-ethyl ester;2-CHLORO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER;2-chloro-4-(trifluoromethyl)-5-thiazolecarboxylic acid ethyl ester;5-Thiazolecarboxylic acid, 2-chloro-4-(trifluoromethyl)-, ethyl ester
CBNumber:
CB3109311
Molecular Formula:
C7H5ClF3NO2S
Molecular Weight:
259.63
MDL Number:
MFCD02956778
MOL File:
72850-52-3.mol
MSDS File:
SDS
Last updated:2026-05-28 00:55:26
Product description Number Pack Size Price
Ethyl 2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate ≥95% PC14280 100mg $21
Ethyl 2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate ≥95% PC14280 250mg $24
Ethyl 2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate ≥95% PC14280 100mg $21
Ethyl 2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate ≥95% PC14280 250mg $24
Ethyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate 306643 100.00mg $15
More product size

ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE Properties

Melting point 57-59
Boiling point 308.7±52.0 °C(Predicted)
Density 1.509±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -4.03±0.10(Predicted)
Appearance Light yellow to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P260-P280-P312
Hazard Codes  Xi
HazardClass  IRRITANT
HS Code  2934100090

ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC14280 Ethyl 2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate ≥95% 72850-52-3 100mg $21 2026-06-04 Buy
Apolloscientific PC14280 Ethyl 2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate ≥95% 72850-52-3 250mg $24 2026-06-04 Buy
Apolloscientific PC14280 Ethyl 2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate ≥95% 72850-52-3 100mg $21 2026-06-04 Buy
Apolloscientific PC14280 Ethyl 2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate ≥95% 72850-52-3 250mg $24 2026-06-04 Buy
Matrix Scientific 306643 Ethyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate 72850-52-3 100.00mg $15 2026-05-19 Buy
Product number Packaging Price Buy
PC14280 100mg $21 Buy
PC14280 250mg $24 Buy
PC14280 100mg $21 Buy
PC14280 250mg $24 Buy
306643 100.00mg $15 Buy

ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE Chemical Properties,Uses,Production

Synthesis

2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

344-72-9

Isoamyl nitrite

110-46-3

ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE

72850-52-3

General procedure: preparation of ethyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate; ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate (1.0 g, 4.16 mmol) was slowly added to CuCl2 (671 mg, 4.99 mmol) and isoamyl nitrite (732 mg, 6.24 mmol) in acetonitrile (10 ml) at 0°C in a in the mixture. The reaction mixture was stirred at room temperature for 1 hour and then heated to 50 °C to continue the reaction for 1 hour. After completion of the reaction, most of the solvent was removed under reduced pressure and the residue was poured into a mixture of ice and concentrated hydrochloric acid. The mixture was extracted with dichloromethane, the organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by fast silica gel column chromatography (eluent: hexane/ethyl acetate = 20:1) to afford the target compound ethyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate (762 mg, 71% yield).1H NMR (300 MHz, DMSO-d6) δ 1.26 (t, J=7.0 Hz, 3H), 4.31 (q, J=7.0 Hz, 2H).

References

[1] Patent: WO2010/56588, 2010, A1. Location in patent: Page/Page column 13

ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE Preparation Products And Raw materials

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ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
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View Lastest Price from ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE pictures 2026-04-17 ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE
72850-52-3
$1.60-9.60 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
5-(trifluoromethyl)thiazol-2-amine pictures 2020-11-16 5-(trifluoromethyl)thiazol-2-amine
72850-52-3
$12.00 25Kg/Bag 99% 20 Tons Longyan Tianhua Biological Technology Co., Ltd

ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE Spectrum

ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE 2-CHLORO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Ethyl 2-chloro-4-(trifluoroMethyl)thiazole-5-carboxylate 2-chloro-4-trifluoromethyl-thiazol-5-carboxylic acid-ethyl ester 2-chloro-4-(trifluoromethyl)-5-thiazolecarboxylic acid ethyl ester 5-Thiazolecarboxylic acid, 2-chloro-4-(trifluoromethyl)-, ethyl ester 72850-52-3 C7H5ClF3NO2S
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