4-Chloro-isatoic anhydride
- CAS No.
- 40928-13-0
- Chemical Name:
- 4-Chloro-isatoic anhydride
- Synonyms
- 7-chloro-2H-benzo[d][1,3]oxazine-2,4(1H)-dione;AURORA KA-6696;6-CHLOROISATOIC ANHYDRIDE;7-CHLOROISATOIC ANHYDRIDE;4-CHLORO-ISATOIC ANHYDRIDE;4-CHLOROISATONIC ANHYDRIDE;4-Chloroisatoic Anhydride >7-chloro-1H-3,1-benzoxazine-2,4-dione;7-chloro-1H-3,1-benzoxazine-2,4-quinone;7-chloro-2H-3,1-benzoxazine-2,4(1H)-dione
- CBNumber:
- CB3190971
- Molecular Formula:
- C8H4ClNO3
- Molecular Weight:
- 197.58
- MDL Number:
- MFCD00090431
- MOL File:
- 40928-13-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Chloroisatoic anhydride 97% | 691720 | 1g | $42.1 |
| 4-Chloroisatoic Anhydride >98.0%(HPLC)(T) | C2790 | 1g | $43 |
| 4-Chloroisatoic Anhydride | C2790 | 5G | $186 |
| 4-CHLORO-ISATOIC ANHYDRIDE 97% | 68187 | 1G | $27 |
| 4-CHLORO-ISATOIC ANHYDRIDE 97% | 68187 | 5G | $87 |
| More product size | |||
| Melting point | 255-259 °C |
|---|---|
| Density | 1.540±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | soluble in Dimethylformamide |
| form | powder to crystal |
| pka | 9.95±0.20(Predicted) |
| color | White to Light yellow |
| InChI | 1S/C8H4ClNO3/c9-4-1-2-5-6(3-4)10-8(12)13-7(5)11/h1-3H,(H,10,12) |
| InChIKey | QRUPDIJQZCABTC-UHFFFAOYSA-N |
| SMILES | Clc1ccc2C(=O)OC(=O)Nc2c1 |
| CAS DataBase Reference | 40928-13-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2934999090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Chloro-isatoic anhydride price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 691720 | 4-Chloroisatoic anhydride 97% | 40928-13-0 | 1g | $42.1 | 2023-06-20 | Buy |
| TCI Chemical | C2790 | 4-Chloroisatoic Anhydride >98.0%(HPLC)(T) | 40928-13-0 | 1g | $43 | 2026-04-30 | Buy |
| TCI Chemical | C2790 | 4-Chloroisatoic Anhydride | 40928-13-0 | 5G | $186 | 2026-04-30 | Buy |
| AstaTech | 68187 | 4-CHLORO-ISATOIC ANHYDRIDE 97% | 40928-13-0 | 1G | $27 | 2026-04-30 | Buy |
| AstaTech | 68187 | 4-CHLORO-ISATOIC ANHYDRIDE 97% | 40928-13-0 | 5G | $87 | 2026-04-30 | Buy |
4-Chloro-isatoic anhydride Chemical Properties,Uses,Production
Chemical Properties
White solid
Synthesis Reference(s)
The Journal of Organic Chemistry, 26, p. 613, 1961 DOI: 10.1021/jo01061a618
Synthesis
32315-10-9
89-77-0
40928-13-0
General procedure for the synthesis of 7-chloro-1H-benzo[d][1,3]oxazine-2,4-dione from triphosgene and 2-amino-4-chlorobenzoic acid: 1. Preparation of Intermediate G: To a stirred solution of 2-amino-4-chlorobenzoic acid (10 g, 0.058 mol) in acetonitrile (60 mL), a solution of pyridine (9.4 mL, 0.117 mol, 2 eq.) and triphosgene (17.3 g, 0.058 mol, 1 eq.) in dichloromethane (85 mL, 0.7 M) was slowly added. 2. Treatment of the reaction mixture: the resulting orange reaction solution was heated at 50 °C for 2 h and subsequently cooled to room temperature. 3. Separation and purification: the reaction solution was diluted with water (50 mL) to separate the organic and aqueous layers. The aqueous layer was extracted with dichloromethane (3 x 50 mL) and the combined organic layers were washed once with brine (50 mL) and dried with anhydrous magnesium sulfate. 4. Purification of products: The reaction solution was heated at 50 °C for 2 h and subsequently cooled to room temperature. 4. Purification of product: The solvent was removed by distillation under reduced pressure to give a yellow solid. The solid was recrystallized from hexane to give 7-chloro-1H-benzo[d][1,3]oxazine-2,4-dione (9.1 g, 74% yield) as a yellow solid. 1H NMR (acetone-d6, 500 MHz): δ (ppm) 7.13-7.14 (1H, s), 7.28-7.30 (1H, d, J = 8.5 Hz), 7.90-7.92 (1H, d, J = 8.6 Hz), 11.84 (1H, bs).
References
[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 17, p. 6928 - 6937
[2] Journal of Medicinal Chemistry, 2006, vol. 49, # 7, p. 2311 - 2319
[3] Patent: US9126978, 2015, B2. Location in patent: Page/Page column 57; 58
[4] European Journal of Medicinal Chemistry, 1994, vol. 29, # 12, p. 925 - 940
[5] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 10, p. 2295 - 2299
4-Chloro-isatoic anhydride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hefei Lbao Physical & Chemical Science Co.,Ltd | +15184799099 | lbaochemicals@gmail.com | China | 670 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15082 | 58 |
View Lastest Price from 4-Chloro-isatoic anhydride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-18 | 4-chloroisatoic anhydride
40928-13-0
|
1kg | 98% | Hefei Lbao Physical & Chemical Science Co.,Ltd | |||
 |
2020-01-01 | 4-Chloro-isatoic anhydride
40928-13-0
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 4-chloroisatoic anhydride
40928-13-0
- $0.00
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- 4-Chloro-isatoic anhydride
40928-13-0
- $1.00
- 99%
- Career Henan Chemical Co
