8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one
![8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one Structure](CAS/GIF/37949-03-4.gif)
- CAS No.
- 37949-03-4
- Chemical Name:
- 8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one
- Synonyms
- 5,6,8,9-tetrahydro-7H-benzo[7]annulen-7-one;6,7,8,9-Tetrahydro-5H-benzo[7]annulen-7-one;CPD1725-A3;3-Benzosuberone;BGB-324 intermediate;7-benzocycloheptanone;7-benzenebenzocycloheptylone;8,9-Dihydro-5H-benzo[7]annulen-7(6H);5,6,8,9-tetrahydrobenzo[7]annulen-7-one;8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one
- CBNumber:
- CB32535792
- Molecular Formula:
- C11H12O
- Molecular Weight:
- 160.21
- MDL Number:
- MFCD09867716
- MOL File:
- 37949-03-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5,6,8,9-Tetrahydrobenzocyclohepten-7-one | MBA94903 | 5g | $354 |
| 6,7,8,9-Tetrahydro-5H-benzo[7]annulen-7-one 98% | OR310416 | 100mg | $21 |
| 6,7,8,9-Tetrahydro-5H-benzo[7]annulen-7-one 98% | OR310416 | 250mg | $24 |
| 6,7,8,9-Tetrahydro-5H-benzo[7]annulen-7-one 98% | OR310416 | 1g | $33 |
| 6,7,8,9-Tetrahydro-5H-benzo[7]annulen-7-one 98% | OR310416 | 5g | $158 |
| More product size | |||
| Melting point | 38.5 °C |
|---|---|
| Boiling point | 288.2±29.0 °C(Predicted) |
| Density | 1.064±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| Appearance | Off-white to light yellow <38.5°C Solid,>38.5°C Liquid |
| InChI | InChI=1S/C11H12O/c12-11-7-5-9-3-1-2-4-10(9)6-8-11/h1-4H,5-8H2 |
| InChIKey | MRLBDJHIJZHYMK-UHFFFAOYSA-N |
| SMILES | C12=CC=CC=C1CCC(=O)CC2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2916199590 |
8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | MBA94903 | 5,6,8,9-Tetrahydrobenzocyclohepten-7-one | 37949-03-4 | 5g | $354 | 2026-06-04 | Buy |
| Apolloscientific | OR310416 | 6,7,8,9-Tetrahydro-5H-benzo[7]annulen-7-one 98% | 37949-03-4 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR310416 | 6,7,8,9-Tetrahydro-5H-benzo[7]annulen-7-one 98% | 37949-03-4 | 250mg | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR310416 | 6,7,8,9-Tetrahydro-5H-benzo[7]annulen-7-one 98% | 37949-03-4 | 1g | $33 | 2026-06-04 | Buy |
| Apolloscientific | OR310416 | 6,7,8,9-Tetrahydro-5H-benzo[7]annulen-7-one 98% | 37949-03-4 | 5g | $158 | 2026-06-04 | Buy |
8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one Chemical Properties,Uses,Production
Uses
8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one is a reactant in the preparation of benzo[7]annulen-7-amines with GluN2B affinity and selectivity.
Synthesis
24790-66-7
![8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one](/CAS/GIF/37949-03-4.gif)
37949-03-4
The general procedure for the synthesis of 8,9-dihydro-5H-benzo[7]roten-7(6H)-ones from the compound (CAS:24790-66-7) was as follows: first, 3 5,6,8,9-tetrahydro-benzocyclohepten-7-one (compound of formula II) was prepared. A mixture of isomers of dimethyl 7-oxo-5,6,8,9-tetrahydrobenzocycloheptene-6,8-dicarboxylate (80 g, obtained according to Preparation 2) was dissolved in a mixture of aqueous 3M sulfuric acid (300 mL) and acetonitrile (50 mL) under argon protection and refluxed overnight. Upon completion of the reaction, the mixture was diluted with ether, neutralized with 2M aqueous sodium hydroxide solution (3 x 300 mL), subsequently dried with magnesium sulfate and evaporated to dryness. The residue was distilled at 97-98 °C, 0.4-0.5 Torr to give colorless crystals (26.1 g, 84% yield, α,α'-dibromo-o xylene). The melting point of the product was 43-44 °C. The 1H-NMR (CDCl3) data were as follows: 7.23 (m, 4H, aromatic hydrogen); 2.91 (m, 2H, hydrogen in the C(6) and C(8) positions); 2.62 (m, 2H, hydrogen in the C(5) and C(9) positions).
References
[1] Patent: US2010/69504, 2010, A1. Location in patent: Page/Page column 5
[2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 23, p. 6638 - 6646
[3] Patent: WO2008/83367, 2008, A2. Location in patent: Page/Page column 132-133
[4] Patent: WO2010/5876, 2010, A2. Location in patent: Page/Page column 55-56
[5] Drugs of the Future, 2018, vol. 43, # 9, p. 645 - 653
8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 | sophieliu@speranzachem.com | China | 923 | 55 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9542 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9539 | 58 |
| Sense Chemicals (Shanghai) Co., Ltd. | +86-21-52751036; +8613818977689 | david.dai@sensechemicals.com | China | 225 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
View Lastest Price from 8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one pictures](/ProductImageEN1/2025-06/Small/736cd4ed-1735-4039-91b8-d694d46a22de.png) |
2025-12-01 | 8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one
37949-03-4
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2020-01-10 | 5,6,8,9-Tetrahydro-7H-benzocyclohepten-7-one
37949-03-4
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one
37949-03-4
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 5,6,8,9-Tetrahydro-7H-benzocyclohepten-7-one
37949-03-4
- $1.00
- 99%
- Career Henan Chemical Co
