4-(Trifluoromethoxy)aniline
- CAS No.
- 461-82-5
- Chemical Name:
- 4-(Trifluoromethoxy)aniline
- Synonyms
- Trifluoromethoxyaniline;Riluzole Related CoMpound A;p-Trifluoromethoxyaniline;4-TRIFLUOROMETHOXY-PHENYLAMINE;AKOS B016000;4-(TrifluoroMe;Riluzole USP RC A;TIMTEC-BB SBB001667;Riluzole Impurity 10;4-Trifluoroethoxyaniline
- CBNumber:
- CB3322028
- Molecular Formula:
- C7H6F3NO
- Molecular Weight:
- 177.12
- MDL Number:
- MFCD00041314
- MOL File:
- 461-82-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-(Trifluoromethoxy)aniline 98% | 337056 | 5g | $51.3 |
| Riluzole Related Compound A pharmaceutical secondary standard, certified reference material | PHR3132 | 50MG | $593 |
| Riluzole Related Compound A United States Pharmacopeia (USP) Reference Standard | 1604348 | 25mg | $1290 |
| 4-(Trifluoromethoxy)aniline >98.0%(GC)(T) | T1345 | 5g | $23 |
| 4-(Trifluoromethoxy)aniline >98.0%(GC)(T) | T1345 | 25g | $47 |
| More product size | |||
| Boiling point | 73-75 °C10 mm Hg(lit.) |
|---|---|
| Density | 1.32 g/mL at 20 °C(lit.) |
| refractive index |
n |
| Flash point | 177 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| pka | 3.75±0.10(Predicted) |
| form | Liquid |
| color | Clear colorless to yellow |
| Specific Gravity | 1.310 |
| BRN | 2090209 |
| Stability | Hygroscopic |
| InChI | InChI=1S/C7H6F3NO/c8-7(9,10)12-6-3-1-5(11)2-4-6/h1-4H,11H2 |
| InChIKey | XUJFOSLZQITUOI-UHFFFAOYSA-N |
| SMILES | C1(N)=CC=C(OC(F)(F)F)C=C1 |
| CAS DataBase Reference | 461-82-5(CAS DataBase Reference) |
| FDA UNII | P40L42CVF6 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H310-H315-H318-H373 | |||||||||
| Precautionary statements | P260-P280-P280-P301+P330+P331+P310-P302+P352+P310-P305+P351+P338+P310 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | T,Xi,Xn | |||||||||
| Risk Statements | 24/25-33-38-41-36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36/37/39-45-36 | |||||||||
| RIDADR | UN 2941 6.1/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| Hazard Note | Toxic | |||||||||
| HazardClass | 6.1 | |||||||||
| HazardClass | IRRITANT, TOXIC | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29222900 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
|||||||||
| Hazard Classifications | Acute Tox. 2 Dermal Acute Tox. 3 Oral Eye Dam. 1 Skin Irrit. 2 STOT RE 2 |
|||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
4-(Trifluoromethoxy)aniline price More Price(82)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 337056 | 4-(Trifluoromethoxy)aniline 98% | 461-82-5 | 5g | $51.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR3132 | Riluzole Related Compound A pharmaceutical secondary standard, certified reference material | 461-82-5 | 50MG | $593 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1604348 | Riluzole Related Compound A United States Pharmacopeia (USP) Reference Standard | 461-82-5 | 25mg | $1290 | 2026-04-30 | Buy |
| TCI Chemical | T1345 | 4-(Trifluoromethoxy)aniline >98.0%(GC)(T) | 461-82-5 | 5g | $23 | 2026-04-30 | Buy |
| TCI Chemical | T1345 | 4-(Trifluoromethoxy)aniline >98.0%(GC)(T) | 461-82-5 | 25g | $47 | 2026-04-30 | Buy |
4-(Trifluoromethoxy)aniline Chemical Properties,Uses,Production
Chemical Properties
CLEAR YELLOW LIQUID
Uses
4-(Trifluoromethoxy)aniline was used in the synthesis of:
- side-group liquid-crystalline polymethacrylates with fluorine-containing mesogens
- derivatives of 3-(quinolin-3-yl)acrylates
- series of novel Shiff bases, via condensation with pyridinecarboxaldehydes in the presence of molecular sieves
Uses
4-(Trifluoromethoxy)aniline is used in the synthesis of anticancer agents and antitumor medicaments. Also, its an intermediate in the production of labelled Riluzole, a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant.
Synthesis
407-14-7
461-82-5
General procedure: To a flame-dried 25 mL round-bottom flask were added activated magnesium chips (7.5 mmol, 1.5 eq.) and 5 mL of anhydrous tetrahydrofuran (THF). Two drops of 1,2-dibromoethane were added to the suspension to initiate the reaction. 5 min later, a solution of p-bromotrifluoromethoxybenzene (5 mmol, 1.0 eq.) dissolved in 5 mL of anhydrous THF was slowly added to the magnesium suspension at room temperature. A mild exothermic phenomenon was observed during the reaction. After determining the concentration of Grignard's reagent by titration, 1 mmol of the reagent was transferred to another flame-dried reaction flask. The solution was diluted with 3 mL of anhydrous toluene and after cooling to the preset temperature T, a solution of oxazepane (1.2 mmol, 1.2 equiv) dissolved in 1 mL of anhydrous toluene was added. The reaction mixture was held at temperature T for a reaction time t, followed by quenching the reaction with saturated aqueous ammonium chloride (NH4Cl). (Specific reaction temperatures and reaction times need to be listed according to the actual conditions of each substrate.)
References
[1] Organic Letters, 2013, vol. 15, # 14, p. 3734 - 3737
[2] Nature Chemistry, 2017, vol. 9, # 7, p. 681 - 688
[3] Patent: US2018/57444, 2018, A1. Location in patent: Paragraph 0098; 0134; 0135; 0171
4-(Trifluoromethoxy)aniline Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Qi-Chem Co., Ltd. | +86-041188165951 | cristiano.zhang@qi-chem.com | China | 133 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5228 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
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View Lastest Price from 4-(Trifluoromethoxy)aniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-28 | 4-(Trifluoromethoxy)aniline
461-82-5
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-03-20 | 4-(Trifluoromethoxy)aniline
461-82-5
|
1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2025-09-25 | 4-(Trifluoromethoxy)aniline
461-82-5
|
$8.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd |
-
- 4-(Trifluoromethoxy)aniline
461-82-5
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 4-(Trifluoromethoxy)aniline
461-82-5
- $0.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4-(Trifluoromethoxy)aniline
461-82-5
- $8.00
- 99%
- Henan Fengda Chemical Co., Ltd
