ChemicalBook >> CAS DataBase List >>1-Boc-pyrazole-4-boronic acid pinacol ester
1-Boc-pyrazole-4-boronic acid pinacol ester
- CAS No.
- 552846-17-0
- Chemical Name:
- 1-Boc-pyrazole-4-boronic acid pinacol ester
- Synonyms
- tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate;tert-butyl 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate;EOS-60399;1-Boc-4-pyrazo;1-Boc-4-pyrazoL;1-BOC- 4-PYRAZOLEBORONIC ACID PINACOL ESTER;N-BOC-PYRAZOLE-4-BORONIC ACID PINACOL ESTER;1-Boc-pyrazole-4-boronic acid pinacol ester;N-Boc-pyrazole-4-boronic acid pinaxcol ester;1-Boc-pyrazolyl-4-boronic Acid Pinacol Ester
- CBNumber:
- CB3341441
- Molecular Formula:
- C14H23BN2O4
- Molecular Weight:
- 294.15
- MDL Number:
- MFCD05663873
- MOL File:
- 552846-17-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-28 05:09:12
| Product description | Number | Pack Size | Price |
| 1-Boc-pyrazole-4-boronic acid pinacol ester 97% | 632732 | 1 g | $52.3 |
| 1-Boc-pyrazole-4-boronic acid pinacol ester 97% | 632732 | 5 g | $144.75 |
| 1-(tert-Butoxycarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole >98.0%(T) | B5203 | 1g | $42 |
| 1-(tert-Butoxycarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole >98.0%(T) | B5203 | 5g | $120 |
| 1-Boc-4-pyrazoleboronic acid pinacol ester | 261830 | 2g | $319 |
| More product size | |||
| Melting point | 82-86 °C (lit.) |
|---|---|
| Boiling point | 387.9±34.0 °C(Predicted) |
| Density | 1.09±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | soluble in Methanol |
| pka | -1.20±0.12(Predicted) |
| form | Crystalline Powder |
| color | White to beige |
| Water Solubility | insoluble |
| InChI | InChI=1S/C14H23BN2O4/c1-12(2,3)19-11(18)17-9-10(8-16-17)15-20-13(4,5)14(6,7)21-15/h8-9H,1-7H3 |
| InChIKey | IPISOFJLWYBCAV-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)C=C(B2OC(C)(C)C(C)(C)O2)C=N1 |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 22-24/25-37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
1-Boc-pyrazole-4-boronic acid pinacol ester price More Price(89)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 632732 | 1-Boc-pyrazole-4-boronic acid pinacol ester 97% | 1 g | $52.3 | 2026-04-30 | Buy | |
| Sigma-Aldrich | 632732 | 1-Boc-pyrazole-4-boronic acid pinacol ester 97% | 5 g | $144.75 | 2026-04-30 | Buy | |
| TCI Chemical | B5203 | 1-(tert-Butoxycarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole >98.0%(T) | 552846-17-0 | 1g | $42 | 2026-04-30 | Buy |
| TCI Chemical | B5203 | 1-(tert-Butoxycarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole >98.0%(T) | 552846-17-0 | 5g | $120 | 2026-04-30 | Buy |
| Usbiological | 261830 | 1-Boc-4-pyrazoleboronic acid pinacol ester | 552846-17-0 | 2g | $319 | 2026-06-03 | Buy |
1-Boc-pyrazole-4-boronic acid pinacol ester Chemical Properties,Uses,Production
Chemical Properties
white to beige crystalline powder
Uses
1-Boc-pyrazole-4-boronic Acid Pinacol Ester is used as a reagent in the synthesis of several inhibitors including thieno[3,2-c]pyridin-4-amines which are a novel series of Bruton’s tyrosine kinase (BTK) inhibitors which can be used in drug design.
Synthesis
269410-08-4
24424-99-5
552846-17-0
4-Pyrazoleboronic acid pinacol ester (1.16 g, 6.0 mmol) and di-tert-butyl dicarbonate (1.58 g, 7.2 mmol) were used as raw materials and dissolved in dichloromethane (40 mL). A catalytic amount of 4-dimethylaminopyridine (102 mg, 0.84 mmol) was added and the reaction was stirred at room temperature for 4 hours. After completion of the reaction, water was added to the reaction system and extracted with ethyl acetate. The organic phase was washed with saturated aqueous sodium chloride solution and then the solvent was removed by rotary evaporation to give the crude product 1-Boc-pyrazole-4-boronic acid pinacol ester (1.5 g, 85% yield).
References
[1] Patent: CN103936728, 2016, B. Location in patent: Paragraph 0177; 0203; 0204; 0205
[2] Patent: US2006/46991, 2006, A1. Location in patent: Page/Page column 68
[3] Patent: WO2018/154466, 2018, A1. Location in patent: Paragraph 001162; 001164; 001165
[4] Patent: WO2008/88881, 2008, A1. Location in patent: Page/Page column 58
[5] Patent: WO2004/56727, 2004, A2. Location in patent: Page 97
Synthesis of 1-Boc-pyrazole-4-boronic acid pinacol ester from 4-Pyrazoleboronic acid pinacol ester and Di-tert-butyl dicarbonate
1-Boc-pyrazole-4-boronic acid pinacol ester Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Global( 252)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16512 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21586 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
View Lastest Price from 1-Boc-pyrazole-4-boronic acid pinacol ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-04-17 | 1-Boc-4-pyrazoleboronic Acid Pinacol Ester
552846-17-0
|
$3.00-9.00 | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |||
 |
2025-04-04 | 1-Boc-pyrazole-4-boronic acid pinacol ester
552846-17-0
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2021-07-13 | 1-Boc-pyrazole-4-boronic acid pinacol ester
552846-17-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 1-Boc-4-pyrazoleboronic Acid Pinacol Ester
552846-17-0
- $3.00-9.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 1-Boc-pyrazole-4-boronic acid pinacol ester
552846-17-0
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 1-Boc-pyrazole-4-boronic acid pinacol ester
552846-17-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
552846-17-0(1-Boc-pyrazole-4-boronic acid pinacol ester)Related Search:
1-Boc-4-pyrazoleboronic acid pinacol ester, 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-Boc-pyrazole, tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-pyrazolecarboxylate
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4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-Bocpyrazole
tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-pyrazolecarboxylate
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylic acid tert-butyl ester
4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-PYRAZOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
1-TERT-BUTOXYCARBONYL-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER
1-TERT-BUTOXYCARBONYL-4-1H-PYRAZOLEBORONIC ACID, PINACOL ESTER
1-BOC-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRAZOLE
1-(tert-Butoxycarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
1-BOC-1H-pyrazol-4-boronic acid pinacol ester
4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-carboxylic acid tert-butyl ester
1H-Pyrazole-1-carboxylic acid,4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-,1,1-dimethylethyl ester
1-Boc-pyrazole-4-boronic acid pinacol ester
1-tert-Butoxycarbonyl-1H-pyrazole-4-boronic acid pinacol ester
1,1-dimethylethyl ester 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-Pyrazole-1-carboxylic acid
1-tert-Butoxycarbonyl-4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrazole
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole-1-carboxylic acid ter
tert-butyl 4-(hydroxy((3-hydroxy-2,3-dimethylbutan-2-yl)oxy)boryl)-1H-pyrazole-1-carboxylate
1-N-Boc-pyrazole-4-boronic acid pinacol ester
N-BOC-PYRAZOLE-4-BORONIC ACID PINACOL ESTER
1-(tert-Butoxycarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate
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1-Boc-pyrazole-4-boronic acid pinacol ester 97%
1-(tert-Butoxycarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
(1-(TERT-BUTOXYCARBONYL)-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER
EOS-60399
1-Boc-4-pyrazo
1-Boc-4-pyrazoL
tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole-1-carboxylate
1-Boc-pyrazolyl-4-boronic Acid Pinacol Ester
1-(tert-Butoxycarbonyl)pyrazolyl-4-boronic Acid Pinacol Ester
2-(1-tert-Butoxycarbonyl-4-pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
552846-17-0 1-Boc-pyrazole-4-boronic acid pinacol ester
tert-butyl 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate
TERT-BUTYL 4-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRAZOLE-1-CARBOXYLATE
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-carboxylate
6-(tert-butyl 4-(tetramethyl-1 ,3,2- dioxaborolan-2-yl)- 1H-pyrazole- 1-carboxylate
Tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate - [T8967]
1-Boc-pyrazole-4-boronic acid pinacol ester
1-Boc-pyrazol-4-ylboronic acid pinacol ester
tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate
552846-17-0
552846-17-
C14H23BN2O4
Boric Acid| Boric Acid Ester| Potassium Trifluoroborate
