6-CHLORO-2-IODO-3-HYDROXYPYRIDINE
- CAS No.
- 188057-26-3
- Chemical Name:
- 6-CHLORO-2-IODO-3-HYDROXYPYRIDINE
- Synonyms
- 6-Chloro-2-iodopyridin-3-ol;6-Chloro-2-iodo-3-pyridinol;3-Pyridinol,6-chloro-2-iodo-;6-Chloro-3-hydroxy-2-iodopyridine;6-CHLORO-2-IODO-3-HYDROXYPYRIDINE;3-Hydroxy-6-chloro-2-iodopyridine;6-Chloro-2-iodo-3-hydroxypyridine,98%;6-CHLORO-2-IODO-3-HYDROXYPYRIDINE ISO 9001：2015 REACH
- CBNumber:
- CB3400865
- Molecular Formula:
- C5H3ClINO
- Molecular Weight:
- 255.44
- MDL Number:
- MFCD07636749
- MOL File:
- 188057-26-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 6-Chloro-2-iodo-3-hydroxypyridine >98.0%(GC)(T) | C3366 | 1g | $81 |
| 6-Chloro-2-iodo-3-hydroxypyridine >98.0%(GC)(T) | C3366 | 5g | $240 |
| 6-Chloro-2-iodopyridin-3-ol 98% | AS48499 | 1g | $33 |
| 6-Chloro-2-iodopyridin-3-ol 98% | AS48499 | 5g | $150 |
| 6-Chloro-2-iodopyridin-3-ol 98% | AS48499 | 25g | $518 |
| More product size | |||
| Melting point | 191-193℃ |
|---|---|
| Boiling point | 333℃ |
| Density | 2.219 |
| Flash point | 155℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Slightly Soluble (1.3 g/L) (25°C). |
| form | powder to crystal |
| pka | 4.22±0.10(Predicted) |
| color | White to Yellow to Green |
| Sensitive | Light Sensitive |
| InChI | InChI=1S/C5H3ClINO/c6-4-2-1-3(9)5(7)8-4/h1-2,9H |
| InChIKey | FWIMPBYPMQSSCD-UHFFFAOYSA-N |
| SMILES | C1(I)=NC(Cl)=CC=C1O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2933.39.9200 | |||||||||
| NFPA 704 |
|
6-CHLORO-2-IODO-3-HYDROXYPYRIDINE price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C3366 | 6-Chloro-2-iodo-3-hydroxypyridine >98.0%(GC)(T) | 188057-26-3 | 1g | $81 | 2026-04-30 | Buy |
| TCI Chemical | C3366 | 6-Chloro-2-iodo-3-hydroxypyridine >98.0%(GC)(T) | 188057-26-3 | 5g | $240 | 2026-04-30 | Buy |
| Activate Scientific | AS48499 | 6-Chloro-2-iodopyridin-3-ol 98% | 188057-26-3 | 1g | $33 | 2026-06-04 | Buy |
| Activate Scientific | AS48499 | 6-Chloro-2-iodopyridin-3-ol 98% | 188057-26-3 | 5g | $150 | 2026-06-04 | Buy |
| Activate Scientific | AS48499 | 6-Chloro-2-iodopyridin-3-ol 98% | 188057-26-3 | 25g | $518 | 2026-06-04 | Buy |
6-CHLORO-2-IODO-3-HYDROXYPYRIDINE Chemical Properties,Uses,Production
Uses
2,2'-Dipyridylamine has been obtained by by heating a mixture of 2-aminopyridine and 2-bromo- (chloro-, iodo- ) -pyridine with anhydrous zinc chloride or with barium oxide.
Synthesis
41288-96-4
188057-26-3
Step 1: 6-Chloropyridin-3-ol (112 g, 868 mmol) was used as a raw material and dissolved in a solvent mixture of THF (800 mL) and water (800 mL). Sodium carbonate (92.0 g, 1.736 mol) and iodine (244.2 g, 1.04 mol) were subsequently added. The reaction mixture was stirred at room temperature for 4 hours. Upon completion of the reaction, the aqueous and organic phases were separated and the product was mainly present in the aqueous phase. The aqueous phase product was washed with hexane (400 mL x 2) to remove impurities. Next, the pH of the aqueous phase was adjusted to 7 with hydrochloric acid and extracted with ethyl acetate (500 mL x 4). The organic layers were combined, dried with anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to obtain the crude product, which was washed with ethyl acetate to give a final 6-chloro-2-iodopyridin-3-ol 163 g in 75% yield. The structure of the product was confirmed by 1H NMR (DMSO, 400 MHz): δ 11.13 (s, 1H, OH), 7.31 (dd, J = 8.4,12.8 Hz, 2H).
References
[1] Tetrahedron Letters, 2003, vol. 44, # 4, p. 725 - 728
[2] Patent: US6696439, 2004, B1. Location in patent: Page column 20
[3] Patent: WO2015/165428, 2015, A1. Location in patent: Page/Page column 18
[4] Organic Process Research and Development, 2016, vol. 20, # 7, p. 1227 - 1238
[5] Patent: US2011/76291, 2011, A1. Location in patent: Page/Page column 148
6-CHLORO-2-IODO-3-HYDROXYPYRIDINE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5742 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4017 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20725 | 58 |
View Lastest Price from 6-CHLORO-2-IODO-3-HYDROXYPYRIDINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-11-18 | 6-CHLORO-2-IODO-3-HYDROXYPYRIDINE
188057-26-3
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2025-04-04 | 6-CHLORO-2-IODO-3-HYDROXYPYRIDINE
188057-26-3
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-07-12 | 6-CHLORO-2-IODO-3-HYDROXYPYRIDINE
188057-26-3
|
$1.00 | 1KG | 99% | 1ton | Career Henan Chemical Co |
-
- 6-CHLORO-2-IODO-3-HYDROXYPYRIDINE
188057-26-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 6-CHLORO-2-IODO-3-HYDROXYPYRIDINE
188057-26-3
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 6-CHLORO-2-IODO-3-HYDROXYPYRIDINE
188057-26-3
- $1.00
- 99%
- Career Henan Chemical Co
