Boc-D-Asparagine
- CAS No.
- 75647-01-7
- Chemical Name:
- Boc-D-Asparagine
- Synonyms
- BOC-D-ASN-OH;BOC-D-ASN;Nα-(tert-Butoxycarbonyl)-D-asparagine;Nalpha D;Z-D-Leu.DCHA;N-BOC-D-Asn-OH;BOC-D-ASPARAGINE;Nα-Boc-D-asparag;N-BOC-D-ASPARAGINE;Nalpha-BOC-D-Asn-OH
- CBNumber:
- CB3408755
- Molecular Formula:
- C9H16N2O5
- Molecular Weight:
- 232.23
- MDL Number:
- MFCD00065558
- MOL File:
- 75647-01-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Boc-D-Asn-OH Novabiochem? | 8.53088 | 25g | $1510 |
| Boc-D-Asn-OH ≥98.0% (TLC) | 15064 | 5g | $224 |
| Nalpha-(tert-Butoxycarbonyl)-D-asparagine >98.0%(HPLC)(T) | B2964 | 5g | $17 |
| Nalpha-(tert-Butoxycarbonyl)-D-asparagine >98.0%(HPLC)(T) | B2964 | 25g | $49 |
| Nα-Boc-D-asparagine | 461069 | 5g | $403 |
| More product size | |||
| Melting point | 165-169 °C |
|---|---|
| alpha | 9 º (c=1, DMF) |
| Boiling point | 374.39°C (rough estimate) |
| Density | 1.2896 (rough estimate) |
| refractive index | 7.7 ° (C=1, DMF) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | soluble in Dimethylformamide |
| pka | 3.79±0.10(Predicted) |
| form | Powder |
| color | White |
| BRN | 4843040 |
| Major Application | peptide synthesis |
| InChI | 1S/C9H16N2O5/c1-9(2,3)16-8(15)11-5(7(13)14)4-6(10)12/h5H,4H2,1-3H3,(H2,10,12)(H,11,15)(H,13,14)/t5-/m1/s1 |
| InChIKey | FYYSQDHBALBGHX-RXMQYKEDSA-N |
| SMILES | CC(C)(C)OC(=O)N[C@H](CC(N)=O)C(O)=O |
| CAS DataBase Reference | 75647-01-7(CAS DataBase Reference) |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 24/25-45 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29241990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Boc-D-Asparagine price More Price(97)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.53088 | Boc-D-Asn-OH Novabiochem? | 75647-01-7 | 25g | $1510 | 2026-04-30 | Buy |
| Sigma-Aldrich | 15064 | Boc-D-Asn-OH ≥98.0% (TLC) | 75647-01-7 | 5g | $224 | 2026-04-30 | Buy |
| TCI Chemical | B2964 | Nalpha-(tert-Butoxycarbonyl)-D-asparagine >98.0%(HPLC)(T) | 75647-01-7 | 5g | $17 | 2026-04-30 | Buy |
| TCI Chemical | B2964 | Nalpha-(tert-Butoxycarbonyl)-D-asparagine >98.0%(HPLC)(T) | 75647-01-7 | 25g | $49 | 2026-04-30 | Buy |
| Usbiological | 461069 | Nα-Boc-D-asparagine | 75647-01-7 | 5g | $403 | 2026-06-03 | Buy |
Boc-D-Asparagine Chemical Properties,Uses,Production
Chemical Properties
white fine crystalline powder
Uses
Nα-Boc-D-asparagine is an N-Boc-protected form of D-Asparagine (A788990). D-Asparagine is an isomer of L-Asparagine (A790005) and is used by bacteria (such as Saccharomyces cerevisiae) as a sole nitrogen source for replication. L-Asparagine is also a competitive inhibitor of staphylococcal L-asparaginase and is used as a reagent to synthesize peptide antibiotics.
Definition
ChEBI: Boc-D-asparagine is an asparagine derivative.
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
2058-58-4
24424-99-5
7536-55-2
General procedure for the synthesis of BOC-L-asparagine from D-asparagine monohydrate and di-tert-butyl dicarbonate: in Example 75, 5-[5-fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidene-methylene]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid [(S)-1-(2-methoxy-ethyl)-2,5-dioxo-pyrrolidin- 3-yl]-amide ester (75a, 2.0 g, 15 mmol) and Na2CO3 (1.6 g, 15 mmol) were dissolved in a solvent mixture of H2O/1,4-dioxane (30 mL/30 mL). To this solution, di-tert-butyl dicarbonate (Boc)2O (3.96 g, 18.2 mmol) was added dropwise at room temperature. The reaction mixture was stirred overnight and subsequently 1,4-dioxane was removed by evaporation. The remaining aqueous solution was adjusted to pH=2 with 37% HCl. The precipitate precipitated was filtered, washed with water and dried to afford the target product 75b (2.97 g, 84% yield) as a white solid.
References
[1] Patent: WO2008/33562, 2008, A2. Location in patent: Page/Page column 86
[2] Patent: US2009/76005, 2009, A1. Location in patent: Page/Page column 44
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 7, p. 2936 - 2947
[4] Journal of the American Chemical Society, 2014, vol. 136, # 26, p. 9244 - 9247
Boc-D-Asparagine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6366 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Nanjing Fred Technology Co., Ltd. | +86-02584696168 15380713688 | Austin@fredchem.cn | CHINA | 865 | 58 |
View Lastest Price from Boc-D-Asparagine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-04-04 | Boc-D-Asparagine
75647-01-7
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
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 |
2019-07-06 | Boc-D-Asparagine
75647-01-7
|
$100.00 | 1KG | 99% | Career Henan Chemical Co |
-
- Boc-D-Asparagine
75647-01-7
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Boc-D-Asparagine
75647-01-7
- $100.00
- 99%
- Career Henan Chemical Co
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