7-AVCA
- CAS No.
- 79349-82-9
- Chemical Name:
- 7-AVCA
- Synonyms
- 7-AMINO-3-VINYLCEPHALOSPORANIC ACID;(6R,7R)-7-AMino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;7-AVCA/(6R,7R)-7-AMino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;7-AVCA;Cefixime Impurity 8;Cefdinir Impurity 30;Cefixime Inermediates;Cefdinir CP Impurity C;Cefdinir Impurity C(CP);Cefixime Impurity 7 AVCA
- CBNumber:
- CB3457874
- Molecular Formula:
- C9H10N2O3S
- Molecular Weight:
- 226.25
- MDL Number:
- MFCD07782149
- MOL File:
- 79349-82-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 7-Amino-3-vinyl-3-cephem-4-carboxylic Acid | 002608 | 100mg | $531 |
| 7-AVCA ≥98% | CS-0144678 | 5g | $29 |
| 7-AVCA ≥98% | CS-0144678 | 10g | $48 |
| 7-AVCA ≥98% | CS-0144678 | 25g | $94 |
| 7-AVCA ≥98% | CS-0144678 | 100g | $295 |
| More product size | |||
| Melting point | 215-220°C |
|---|---|
| Boiling point | 540.7±50.0 °C(Predicted) |
| Density | 1.55±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | Aqueous Base (Slightly), DMSO (Slightly) |
| form | Solid |
| pka | 2.73±0.50(Predicted) |
| color | White to Pale Yellow |
| InChI | InChI=1S/C9H10N2O3S/c1-2-4-3-15-8-5(10)7(12)11(8)6(4)9(13)14/h2,5,8H,1,3,10H2,(H,13,14)/t5-,8-/m1/s1 |
| InChIKey | GQLGFBRMCCVQLU-SVGQVSJJSA-N |
| SMILES | N12[C@@]([H])([C@H](N)C1=O)SCC(C=C)=C2C(O)=O |
| CAS DataBase Reference | 79349-82-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H334 |
| Precautionary statements | P261-P285-P304+P341-P342+P311-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
| REACH Registrations | Active |
7-AVCA price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 002608 | 7-Amino-3-vinyl-3-cephem-4-carboxylic Acid | 79349-82-9 | 100mg | $531 | 2026-06-03 | Buy |
| ChemScene | CS-0144678 | 7-AVCA ≥98% | 79349-82-9 | 5g | $29 | 2026-06-04 | Buy |
| ChemScene | CS-0144678 | 7-AVCA ≥98% | 79349-82-9 | 10g | $48 | 2026-06-04 | Buy |
| ChemScene | CS-0144678 | 7-AVCA ≥98% | 79349-82-9 | 25g | $94 | 2026-06-04 | Buy |
| ChemScene | CS-0144678 | 7-AVCA ≥98% | 79349-82-9 | 100g | $295 | 2026-06-04 | Buy |
7-AVCA Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
A key intermediate in the manufacturing of Cephalosporin compounds.
Synthesis
33748-00-4
79349-82-9
The general procedure for the synthesis of (6R,7R)-7-amino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid from cefixime impurity is as follows: 25.5 g (0.05 mol) of GVNA was placed in a 1,000 mL three-necked flask fitted with a thermometer and a mechanical stirrer, and 300 g of phenol and 2.8 g of acetic acid and the reaction was held at 35°C. After the reaction was complete (about 6 hours), the reaction mixture was slowly poured into a mixed solution consisting of sodium bicarbonate, purified water, and butyl acetate (5 g of purified water, 200 mL of purified water, and 200 mL of butyl acetate). The aqueous phase was extracted twice with 50 mL of butyl acetate and the aqueous phases were combined. The aqueous phase was transferred to a 500 mL reaction flask and stirred at room temperature for 2 hours. 4 g of immobilized acyltransferase PGA-450 was added, followed by dropwise addition of 15% aqueous sodium carbonate solution, maintaining the pH between 8.0-8.2 until the HPLC assay showed less than 0.5% GVNA. The enzyme was recovered by filtration. The filtrate was collected and the pH was adjusted with 10% hydrochloric acid to 3.4. The filter cake was washed with 50 mL of acetone and dried to give 10.7 g of AVNA (93.8% yield as GVNA).
References
[1] Patent: CN104045655, 2016, B. Location in patent: Paragraph 0061
[2] Organic Process Research and Development, 2009, vol. 13, # 5, p. 924 - 927
[3] Patent: CN103923104, 2016, B. Location in patent: Paragraph 0032-0034
7-AVCA Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Tosun Pharmaceutical Ltd | +86-020-61855200-902 +8618124244216 | info@upharm.cn | China | 897 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 722 | 55 | |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6366 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | 1059@dideu.com | China | 3587 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
View Lastest Price from 7-AVCA manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-08 | 7-AVCA
79349-82-9
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-03-12 | Cefixime Impurity
79349-82-9
|
10mg | 98% | 500mg | ShenZhen H&D Pharmaceutical Technology Co., LTD | ||
 |
2025-12-19 | Cefixime Impurity 8 | 5mg | 95%+ | 1000mg | Guangzhou Tosun Pharmaceutical Ltd |
-
- 7-AVCA
79349-82-9
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Cefixime Impurity
79349-82-9
- 98%
- ShenZhen H&D Pharmaceutical Technology Co., LTD
-
- Cefixime Impurity 8
- 95%+
- Guangzhou Tosun Pharmaceutical Ltd
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