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ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE

ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE structure

CAS No.: 304693-64-9

Chemical Name:: ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE

Synonyms: Ethyl 2-(trifluoromethyl);5-(Ethoxycarbonyl)-2-(trifluoromethyl)pyrimidine;ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE;5-PYRIMIDINECARBOXYLIC ACID, 2-(TRIFLUOROMETHYL)-, ETHYL ESTER;Ethyl?2-(trifluoromethyl)pyrimidine-5-carboxylate CAS：304693-64-9;ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ISO 9001：2015 REACH

CBNumber:: CB3523533

Molecular Formula:: C8H7F3N2O2

Molecular Weight:: 220.15

MDL Number:: MFCD09754048

MOL File:: 304693-64-9.mol

MSDS File:: SDS

Last updated:2026-05-28 02:45:41

Product description	Number	Pack Size	Price
Ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate 98%	PC11106	250mg	$21
Ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate 98%	PC11106	1g	$25
Ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate 98%	PC11106	5g	$100
Ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate 98%	PC11106	25g	$448
Ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate 98%	PC11106	100g	$1427

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ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE Properties

Melting point	65 °C
Boiling point	194℃
Density	1.344
Flash point	71℃
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	powder
pka	-3.50±0.22(Predicted)
color	Yellow
InChI	InChI=1S/C8H7F3N2O2/c1-2-15-6(14)5-3-12-7(13-4-5)8(9,10)11/h3-4H,2H2,1H3
InChIKey	LRUCUGOOQHJEQP-UHFFFAOYSA-N
SMILES	C1(C(F)(F)F)=NC=C(C(OCC)=O)C=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332-H315-H319-H335
Precautionary statements	P260-P280-P271
HS Code	2933599590

ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	PC11106	Ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate 98%	304693-64-9	250mg	$21	2026-06-04	Buy
Apolloscientific	PC11106	Ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate 98%	304693-64-9	1g	$25	2026-06-04	Buy
Apolloscientific	PC11106	Ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate 98%	304693-64-9	5g	$100	2026-06-04	Buy
Apolloscientific	PC11106	Ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate 98%	304693-64-9	25g	$448	2026-06-04	Buy
Apolloscientific	PC11106	Ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate 98%	304693-64-9	100g	$1427	2026-06-04	Buy

Product number	Packaging	Price	Buy
PC11106	250mg	$21	Buy
PC11106	1g	$25	Buy
PC11106	5g	$100	Buy
PC11106	25g	$448	Buy
PC11106	100g	$1427	Buy

ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE Chemical Properties,Uses,Production

Uses

Ethyl 2-(Trifluoromethyl)pyrimidine-5-carboxylate is used to prepare NF-κB and AP-1 gene inhibitors.

Synthesis

Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate

720-01-4

ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE

304693-64-9

Ethyl 4-chloro-2-trifluoromethylpyrimidine-5-carboxylate (55.7 g) was added to a mixture of 10% palladium-carbon catalyst (0.3 g), ethanol (1000 ml) and N,N-diisopropylethylamine (90 ml) as a starting material. The reaction was shaken under hydrogen atmosphere at 1 atm for 2 hours. After completion of the reaction, the catalyst was removed by filtration and the solvent was removed by evaporation. The residue was dissolved in dichloromethane, washed sequentially with ammonium chloride solution and water, dried over anhydrous magnesium sulfate, and the solvent was evaporated to afford the target product, ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate, as a light yellow solid (48 g, 100% yield). The structure of the product was confirmed by 1H-NMR (CDCl3) δ 9.42 (2H, s), 4.51 (2H, q), 1.45 (3H, t) and 13C-NMR (CDCl3) δ 162.7,159.4 (2C), 159.3 (q, J=37Hz), 126.3,119.6 (q, J=275Hz), 62.9,. 14.4 Confirmed.

References

[1] Patent: US2004/167142, 2004, A1. Location in patent: Page/Page column 23
[2] Patent: US2013/72470, 2013, A1. Location in patent: Paragraph 0389-0391
[3] Patent: WO2016/91776, 2016, A1. Location in patent: Page/Page column 362
[4] Patent: TW2016/5858, 2016, A. Location in patent: Page/Page column 134
[5] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 1, p. 51 - 55

ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Sodium hydride Silica gel Ethanol Diethyl ether Ethyl acetate

Dichloromethane Ethyl 3,3-Diethoxypropionate Trifluoroacetamidine Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate N,N-Diisopropylethylamine

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Preparation Products

ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE Suppliers

Global( 86)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Shanghai Longyu Biotechnology Co., Ltd.		info@longyupharma.com	China	2421	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8740	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	21157	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58
Shandong Believe Chemical PTE.LTD	+86-18553607090 +8618553607090	1093908296@qq.com	China	1663	58

Supplier	Advantage
Jinan Carbotang Biotech Co.,Ltd.	58
Shanghai Longyu Biotechnology Co., Ltd.	58
Alchem Pharmtech,Inc.	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Shanghai UCHEM Inc.	58
Dideu Industries Group Limited	58
Labnetwork lnc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Shandong Believe Chemical PTE.LTD	58

View Lastest Price from ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-11-18	ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE 304693-64-9	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
	2020-01-09	ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE 304693-64-9	$1.00	1KG	98% HPLC	10 tons/month	Career Henan Chemical Co

ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE
304693-64-9
$1.10
99.00%
Dideu Industries Group Limited

ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE
304693-64-9
$1.00
98% HPLC
Career Henan Chemical Co

ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE Spectrum

ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE(304693-64-9)¹HNMR ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE(304693-64-9)¹⁹FNMR

304693-64-9(ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE)Related Search:

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ETHYL-2-TRIFLUOROMETHYL-4-METHYL-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-TRIFLUOROMETHYL-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-CYCLOPROPYL-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-(2-METHOXYPHENYL)-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-(2-CHLOROPHENYL)-5-PYRIMIDINE CARBOXYLATE

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ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE 5-PYRIMIDINECARBOXYLIC ACID, 2-(TRIFLUOROMETHYL)-, ETHYL ESTER 5-(Ethoxycarbonyl)-2-(trifluoromethyl)pyrimidine Ethyl 2-(trifluoromethyl) ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ISO 9001：2015 REACH Ethyl?2-(trifluoromethyl)pyrimidine-5-carboxylate CAS：304693-64-9 304693-64-9 pyrimidine Fluorine series

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