6-Hydroxy-5-nitronicotinic acid
- CAS No.
- 6635-31-0
- Chemical Name:
- 6-Hydroxy-5-nitronicotinic acid
- Synonyms
- 135339;6-Hydroxy-5-Nitro Niacin;6-hyroxy-5-nitronicotinic acid;Linaprazan Glurate Impurity 51;6-HYDROXY-5-NITRONICOTINIC ACID;5-Nitro-6-hydroxynicotinic acid;6-Hydroxy-5-nitronicotinicAcid>5-CARBOXY-3-NITRO-2(1H)-PYRIDINONE;6-Hydroxy-5-nitronicotinic acid 97%;6-Hydroxy-5-nitropyridine-3-carboxylicaci
- CBNumber:
- CB3671957
- Molecular Formula:
- C6H4N2O5
- Molecular Weight:
- 184.11
- MDL Number:
- MFCD02180840
- MOL File:
- 6635-31-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 6-Hydroxy-5-nitropyridine-3-carboxylic acid 97% | 669679 | 1g | $118 |
| 6-Hydroxy-5-nitropyridine-3-carboxylic acid 97% | 669679 | 5g | $704 |
| 6-Hydroxy-5-nitronicotinic Acid >97.0%(GC)(T) | H1410 | 1g | $105 |
| 6-Hydroxy-5-nitronicotinic Acid >97.0%(GC)(T) | H1410 | 5g | $360 |
| 6-HYDROXY-5-NITRO NICOTINIC ACID 97% | CX1103 | 5G | $30 |
| More product size | |||
| Melting point | 269-271 |
|---|---|
| Boiling point | 363.6±42.0 °C(Predicted) |
| Density | 1.70±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to crystal |
| pka | 3.09±0.50(Predicted) |
| color | Light yellow to Yellow |
| BRN | 177986 |
| InChI | InChI=1S/C6H4N2O5/c9-5-4(8(12)13)1-3(2-7-5)6(10)11/h1-2H,(H,7,9)(H,10,11) |
| InChIKey | VJMXJGVEVASJOD-UHFFFAOYSA-N |
| SMILES | C1NC(=O)C([N+]([O-])=O)=CC=1C(O)=O |
| CAS DataBase Reference | 6635-31-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant/Keep Cold | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 13 - Non Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
6-Hydroxy-5-nitronicotinic acid price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 669679 | 6-Hydroxy-5-nitropyridine-3-carboxylic acid 97% | 6635-31-0 | 1g | $118 | 2022-05-15 | Buy |
| Sigma-Aldrich | 669679 | 6-Hydroxy-5-nitropyridine-3-carboxylic acid 97% | 6635-31-0 | 5g | $704 | 2022-05-15 | Buy |
| TCI Chemical | H1410 | 6-Hydroxy-5-nitronicotinic Acid >97.0%(GC)(T) | 6635-31-0 | 1g | $105 | 2024-03-01 | Buy |
| TCI Chemical | H1410 | 6-Hydroxy-5-nitronicotinic Acid >97.0%(GC)(T) | 6635-31-0 | 5g | $360 | 2024-03-01 | Buy |
| AstaTech | CX1103 | 6-HYDROXY-5-NITRO NICOTINIC ACID 97% | 6635-31-0 | 5G | $30 | 2026-04-30 | Buy |
6-Hydroxy-5-nitronicotinic acid Chemical Properties,Uses,Production
Uses
6-Hydroxy-5-nitronicotinic acid is mainly used as an antibacterial agent and pharmaceutical intermediate.
Application
6-Hydroxy-5-nitronicotinic acid serves as a multifunctional building block in medicinal and agrochemical synthesis: it acts as an antimicrobial agent, a pharmaceutical intermediate for vitamin B3 derivatives and other bio-actives, and a lead compound for antitumor, anti-inflammatory, antifungal and antiviral drug discovery.
Chemical Reactivity
6-Hydroxy-5-nitronicotinic acid is stable under proper conditions, it reacts with oxidizing agents.
Synthesis
6-Hydroxy-5-nitronicotinic acid is synthesised using 6-Hydroxynicotinic acid as a raw material by chemical reaction. The specific synthesis steps are as follows:
6-Hydroxynicotinic acid 2 (25.0 g, 180 mmol) was dissolved in HNO3 fuming (1.52) (95 mL) and stirred at 50 oC for 18 h. After the solution was cooled to room temperature, the mixture was concentrated, and then co-evaporated with water, followed by the addition of MeOH to afford a brown precipitate. The precipitate was filtered and washed with 50 mL of cold MeOH twice. After drying under reduced pressure, a brown color product 3 was obtained; yield: 9.67 g (29percent); 1H NMR (300 MHz, CD3OD) 8.44 (d, J = 2.6 Hz, 1H), 8.85 (d, J = 2.6 Hz, 1H) ; HRMS (ES+): m/z 185.0194 (M+H+) (calcd for C6H5N2O5: 185.0198).
References
[1] Tetrahedron Letters, 1999, vol. 40, # 12, p. 2227 - 2230
[2] Tetrahedron Letters, 2012, vol. 53, # 5, p. 535 - 538
[3] Patent: WO2016/138335, 2016, A1. Location in patent: Paragraph 00372
[4] Journal of the American Chemical Society, 1956, vol. 78, p. 423
[5] Journal of the Chemical Society, 1951, p. 2590,2593
6-Hydroxy-5-nitronicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai jinsheng pharma tech co.,ltd | +8613585563093 | pinpinzheng@jspharmatech.com | China | 374 | 58 |
| Jinan Zhonghan Chemical Technology Co., LTD. | +undefined15066662237 | 3281004549@qq.com | China | 291 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 427 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
View Lastest Price from 6-Hydroxy-5-nitronicotinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 6-Hydroxy-5-nitronicotinic acid
6635-31-0
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-12-01 | 6-Hydroxy-5-nitronicotinic acid
6635-31-0
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-11-18 | 6-Hydroxy-5-nitronicotinic acid
6635-31-0
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
-
- 6-Hydroxy-5-nitronicotinic acid
6635-31-0
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 6-Hydroxy-5-nitronicotinic acid
6635-31-0
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 6-Hydroxy-5-nitronicotinic acid
6635-31-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
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