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3-(Trifluoromethyl)pyrazole

3-(Trifluoromethyl)pyrazole structure

CAS No.: 20154-03-4

Chemical Name:: 3-(Trifluoromethyl)pyrazole

Synonyms: 3-(TRIFLUOROMETHYL)-1H-PYRAZOLE;AKOS B018777;AKOS PAO-1199;BUTTPARK 29\08-71;TIMTEC-BB SBB000068;ART-CHEM-BB B018777;TRIFLUOROMETHYLPYRAZOLE;3-(TRIFLUOROMETHYL)PYRAZOLE;3-(trifloromethyl)-1H-pyrazole;3-(Trifluoromethyl)pyrazole 99%

CBNumber:: CB3681435

Molecular Formula:: C4H3F3N2

Molecular Weight:: 136.08

MDL Number:: MFCD00115018

MOL File:: 20154-03-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:22:13

Product description	Number	Pack Size	Price
3-(Trifluoromethyl)pyrazole 99%	406228	1g	$25
3-(Trifluoromethyl)pyrazole 99%	406228	5g	$67.6
3-(Trifluoromethyl)pyrazole >98.0%(GC)	T2765	1g	$25
3-(Trifluoromethyl)pyrazole >98.0%(GC)	T2765	5g	$71
3-Trifluoromethyl pyrazole Asreported	291015	5g	$325
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3-(Trifluoromethyl)pyrazole Properties

Melting point	45-47 °C (lit.)
Boiling point	70 °C/2 mmHg (lit.)
Density	1.3931 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	powder to crystal
pka	10.56±0.10(Predicted)
color	White to Light yellow
BRN	1564179
InChI	InChI=1S/C4H3F3N2/c5-4(6,7)3-1-2-8-9-3/h1-2H,(H,8,9)
InChIKey	PYXNITNKYBLBMW-UHFFFAOYSA-N
SMILES	N1C=CC(C(F)(F)F)=N1
CAS DataBase Reference	20154-03-4(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-37/39

WGK Germany

HazardClass

IRRITANT

HS Code

29331990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

3-(Trifluoromethyl)pyrazole price More Price(91)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	406228	3-(Trifluoromethyl)pyrazole 99%	20154-03-4	1g	$25	2023-06-20	Buy
Sigma-Aldrich	406228	3-(Trifluoromethyl)pyrazole 99%	20154-03-4	5g	$67.6	2023-06-20	Buy
TCI Chemical	T2765	3-(Trifluoromethyl)pyrazole >98.0%(GC)	20154-03-4	1g	$25	2026-04-30	Buy
TCI Chemical	T2765	3-(Trifluoromethyl)pyrazole >98.0%(GC)	20154-03-4	5g	$71	2026-04-30	Buy
Usbiological	291015	3-Trifluoromethyl pyrazole Asreported	20154-03-4	5g	$325	2026-06-03	Buy

Product number	Packaging	Price	Buy
406228	1g	$25	Buy
406228	5g	$67.6	Buy
T2765	1g	$25	Buy
T2765	5g	$71	Buy
291015	5g	$325	Buy

3-(Trifluoromethyl)pyrazole Chemical Properties,Uses,Production

Chemical Properties

Colorless to light yellow liqui

Uses

3-(Trifluoromethyl)pyrazole may be used in copper-catalyzed pyrazole N-arylation. It may be used in the synthesis of sodium hydridotris(1H-3-trifluoromethylpyrazol-1-yl)borate by heating with sodium borohydride.

Uses

3-(Trifluoromethyl)pyrazole was determined to be a small compound inhibitor of human FATP2.

Definition

ChEBI: 3-(Trifluoromethyl)-1H-pyrazole is a member of pyrazoles.

General Description

3-(Trifluoromethyl)pyrazoles is a heterocyclic building block. It undergoes alkylation with alkyl iodides in DMF to afford the N-alkyl pyrazoles. It participates in the synthesis of disubstituted pyrimidines.

Synthesis

1-Ethoxy-3-trifluoromethyl-1,3-butadiene

59938-06-6

20154-03-4

Example 2 Preparation of 3-(trifluoromethyl)-1H-pyrazole: In a three-necked flask equipped with a mechanical stirrer, a reflux condenser, and a dropping funnel, a solution of 4.4 moles of hydrazine hydrochloride dissolved in 2.2 L of methanol was added. Under nitrogen protection, an equimolar amount of (E)-1-ethoxy-3-trifluoromethyl-1,3-butadiene (ETFBO) was slowly added through the dropping funnel in a titration process for about 4 hours while the temperature of the reaction mixture was controlled to remain below 15 °C. After completion of the dropwise addition, the reaction mixture was refluxed for 12 hours. At the end of the reaction, the reaction solution was filtered and transferred to a 2L flask and concentrated under vacuum (another batch of reaction prepared in parallel under the same conditions, the total yield of the two batches of crude product was about 95%). After combining the two batches of crude product, purification was carried out by short-range vacuum distillation (27 mbar), resulting in 1105 g of pure product in 92% yield of the theoretical value.

References

[1] Patent: WO2010/37688, 2010, A1. Location in patent: Page/Page column 8
[2] Patent: WO2009/14730, 2009, A1. Location in patent: Page/Page column 131-132
[3] Patent: WO2011/17389, 2011, A1. Location in patent: Page/Page column 152
[4] Journal of Organic Chemistry USSR (English Translation), 1990, vol. 26, # 9.1, p. 1623 - 1628
[5] Zhurnal Organicheskoi Khimii, 1990, vol. 26, # 9, p. 1877 - 1883

3-(Trifluoromethyl)pyrazole Preparation Products And Raw materials

Raw materials

n-Butyl vinyl ether Hydrazine monohydrochloride Trifluoroacetic anhydride Pyridine 1-Ethoxy-3-trifluoromethyl-1,3-butadiene

(3Z)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one Hydrazine dihydrochloride Methanol

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Preparation Products

1-Ethyl-3-(trifluoroMethyl)pyrazole 4-(3-Trifluoromethyl-pyrazol-1-yl)-benzaldehyde ethyl [3-(trifluoromethyl)-1H-pyrazol-1-yl]acetate

3-(Trifluoromethyl)pyrazole Suppliers

Global( 315)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Zibo Shiji Zhonglian Medical Technology Co., Ltd.	15069388126 15069388126;	sales@sjzlpharm.com	China	65	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20120	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
Shanghai Arbor Chemical Co., Ltd.	021-60451682	act@arborchemical.com	CHINA	904	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58

Supplier	Advantage
Zibo Shiji Zhonglian Medical Technology Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Shanghai Arbor Chemical Co., Ltd.	58
Changzhou Ansciep Chemical Co., Ltd.	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
HaBo Hong Kong Co., Limited.	58

View Lastest Price from 3-(Trifluoromethyl)pyrazole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-21	3-(Trifluoromethyl)pyrazole 20154-03-4		1kg	98%	20TON	Hubei Lidu New Material Technology Co., Ltd
2026-07-09	3-(Trifluoromethyl)pyrazole 20154-03-4	$5.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2023-06-16	3-(Trifluoromethyl)pyrazole 20154-03-4	$1.00	25KG	99.0%	5000KG/th	Zibo Shiji Zhonglian Medical Technology Co., Ltd.

3-(Trifluoromethyl)pyrazole
20154-03-4
$0.00
98%
Hubei Lidu New Material Technology Co., Ltd

3-(Trifluoromethyl)pyrazole
20154-03-4
$5.00
99%
Henan Fengda Chemical Co., Ltd

3-(Trifluoromethyl)pyrazole
20154-03-4
$1.00
99.0%
Zibo Shiji Zhonglian Medical Technology Co., Ltd.

3-(Trifluoromethyl)pyrazole Spectrum

3-(Trifluoromethyl)pyrazole(20154-03-4)¹HNMR 3-(Trifluoromethyl)pyrazole(20154-03-4)IR

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TIMTEC-BB SBB000068 TRIFLUOROMETHYLPYRAZOLE BUTTPARK 29\08-71 ART-CHEM-BB B018777 AKOS PAO-1199 AKOS B018777 3-(TRIFLUOROMETHYL)PYRAZOLE 3-(Trifluoromethyl)-1H-pyrazole 99% 3-(Trifluoromethyl)-1H-pyrazole99% 7033 3-(TRIFLUORO METHYL)PYRAZOLE 1H-Pyrazole, 3-(trifluoromethyl)- 3-(Trifluoromethyl)pyrazole ,98% 3-(trifloromethyl)-1H-pyrazole 3-(Trifluoromethyl)pyrazole 99% 3-(Trifluoromethyl)pyrazole, 96% 3-(TRIFLUOROMETHYL)-1H-PYRAZOLE 20154-03-4 C4H3F3N2 Pyrazoles Building Blocks Heterocyclic Building Blocks Pyrazoles Pyrazole series

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3-(Trifluoromethyl)pyrazole

3-(Trifluoromethyl)pyrazole Properties

SAFETY

Risk and Safety Statements

3-(Trifluoromethyl)pyrazole price More Price(91)

3-(Trifluoromethyl)pyrazole Chemical Properties,Uses,Production

Chemical Properties

Uses

Uses

Definition

General Description

Synthesis

References

3-(Trifluoromethyl)pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

3-(Trifluoromethyl)pyrazole Suppliers

View Lastest Price from 3-(Trifluoromethyl)pyrazole manufacturers

3-(Trifluoromethyl)pyrazole Spectrum

20154-03-4(3-(Trifluoromethyl)pyrazole)Related Search: