(4-BROMOBENZYL)DIMETHYLAMINE
- CAS No.
- 6274-57-3
- Chemical Name:
- (4-BROMOBENZYL)DIMETHYLAMINE
- Synonyms
- (4-BROMOBENZYL)DIMETHYLAMINE;4-Bromo-N,N-dimethylbenzylamine;(4-BROMOBENZYL)DIMETHYLBENZYLAMINE;4-(N,N-DIMETHYLAMINOMETHYL)BROMOBENZENE;(4-Bromophenyl)-N,N-dimethylmethylamine;4-Bromo-N,N-dimethyl-Benzenemethanamine;1-(4-broMophenyl)-N,N-diMethylMethanaMine;BenzeneMethanaMine, 4-broMo-N,N-diMethyl-;1-(4-Bromophenyl)-N,N-dimethylmethylamine;[(4-bromophenyl)methyl]dimethylamine - [AC78543]
- CBNumber:
- CB3735194
- Molecular Formula:
- C9H12BrN
- Molecular Weight:
- 214.1
- MDL Number:
- MFCD00032473
- MOL File:
- 6274-57-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Bromo-N,N-dimethylbenzylamine 98% | OR3370 | 1g | $52 |
| (4-Bromo-benzyl)-dimethyl-amine 97% | AS70038 | 1g | $74 |
| 4-Bromo-N,N-dimethylbenzylamine 98% | OR3370 | 5g | $137 |
| (4-Bromo-benzyl)-dimethyl-amine 97% | AS70038 | 5g | $210 |
| 4-Bromo-N,N-dimethylbenzylamine 98% | OR3370 | 10g | $252 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Hazard Note | Irritant |
| HS Code | 2921490090 |
(4-BROMOBENZYL)DIMETHYLAMINE price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR3370 | 4-Bromo-N,N-dimethylbenzylamine 98% | 6274-57-3 | 1g | $52 | 2026-06-04 | Buy |
| Activate Scientific | AS70038 | (4-Bromo-benzyl)-dimethyl-amine 97% | 6274-57-3 | 1g | $74 | 2026-06-04 | Buy |
| Apolloscientific | OR3370 | 4-Bromo-N,N-dimethylbenzylamine 98% | 6274-57-3 | 5g | $137 | 2026-06-04 | Buy |
| Activate Scientific | AS70038 | (4-Bromo-benzyl)-dimethyl-amine 97% | 6274-57-3 | 5g | $210 | 2026-06-04 | Buy |
| Apolloscientific | OR3370 | 4-Bromo-N,N-dimethylbenzylamine 98% | 6274-57-3 | 10g | $252 | 2026-06-04 | Buy |
(4-BROMOBENZYL)DIMETHYLAMINE Chemical Properties,Uses,Production
Synthesis
124-40-3
589-15-1
6274-57-3
1. In a flask containing 50% aqueous diethylamine (500 mmol) and K2CO3 (50 mmol), a solution of 4-bromobenzyl bromide (50 mmol) in THF (90 mL) was added slowly and dropwise. The reaction mixture was stirred at 60 °C under Ar atmosphere for 24 hours. After completion of the reaction, water (60 mL) was added and extracted with CHCl3 (100 mL x 3). The organic layers were combined, dried with Na2SO4, filtered and concentrated under reduced pressure to give 4-bromobenzyl dimethylamine in 99% yield (boiling point 55 °C/1 mmHg). 2. Mg (40 mmol) was dried with a vacuum pump at 70 °C for 20 min. To the dried Mg was added a solution of 4-bromobenzyldimethylamine (30 mmol) in anhydrous THF (70 mL) and stirred for 1 h at room temperature under Ar atmosphere. Subsequently, anhydrous THF (30 mL) solution of chlorodiphenylphosphine (30 mmol) was slowly added at 0°C and stirred at room temperature for 2 hours. At the end of the reaction, the mixture was filtered and washed with dichloromethane. To the filtrate was added a 30% aqueous solution of H2O2 (60 mmol) at 0 °C and stirred for 1 h at room temperature. After completion of the reaction, the reaction was quenched with water (100 mL) and extracted with chloroform (50 mL x 3). The organic layer was washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure. To the residue, diethyl ether (300 mL) was added, stirred for 0.5 h to dissolve the product, filtered and concentrated under reduced pressure to give 4-(diphenylphosphinyl)benzyldimethylamine in 95% yield. 3. To a flask containing anhydrous 1,2-dimethoxyethane (200 mL) solution of 4-(diphenylphosphinoyl)benzyldimethylamine (60 mmol) was added dimethyl sulfate (120 mmol) at 0 °C. The mixture was mixed with a mixture of 2,2-dimethoxyethane (200 mL) and 4-(diphenylphosphinoyl)benzyldimethylamine (60 mmol). The mixture was stirred at 50 °C under Ar atmosphere for 1 hour. Subsequently, LiAlH4 (180 mmol) was added at 0 °C and stirred at room temperature for 2 hours. Upon completion of the reaction, it was quenched with ice, then quenched with 1 M aqueous HBr solution (200 mL) and washed with ether (200 mL x 2). The aqueous phase was extracted with dichloromethane (100 mL x 3), the organic layers were combined, dried with Na2SO4, filtered and concentrated under reduced pressure. To the residue, diethyl ether (300 mL) was added, stirred under Ar atmosphere for 0.5 h. 4-(Diphenylphosphino)benzyltrimethylammonium bromide was obtained by filtration in 79% yield.
References
[1] Tetrahedron, 2010, vol. 66, # 19, p. 3421 - 3426
[2] Tetrahedron, 2013, vol. 69, # 19, p. 3971 - 3977
[3] Chemical Communications, 2012, vol. 48, # 63, p. 7823 - 7825
[4] Journal of Organic Chemistry, 2016, vol. 81, # 18, p. 8520 - 8529
[5] Journal of Medicinal Chemistry, 2005, vol. 48, # 7, p. 2667 - 2677
(4-BROMOBENZYL)DIMETHYLAMINE Preparation Products And Raw materials
Raw materials
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Preparation Products
(4-BROMOBENZYL)DIMETHYLAMINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52704 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20000 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; +86-85511178 | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49895 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +86-18327326525 | masar@topule.com | China | 8467 | 58 |
| Sichuan Biosynce Pharmatech Co., Ltd. | diane@biosynce.com | China | 4871 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11780 | 60 |
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