2-Fluoro-5-methylpyridine
- CAS No.
- 2369-19-9
- Chemical Name:
- 2-Fluoro-5-methylpyridine
- Synonyms
- 2-Fluoro-5-m;uoro-5-methyL;6-FLUORO-3-PICOLINE;2-FLUORO-5-PICOLINE;Fluoromethylpyridine3;2-FLUORO-5-METHYPYRIDINE;2-Bromo-1-methylpyridine;2-FLUORO-5-METHYLPYRIDINE;2-Fluoro-5-methylpyridine97%;2-Fluoro-5-methylpyridine>
- CBNumber:
- CB3742934
- Molecular Formula:
- C6H6FN
- Molecular Weight:
- 111.12
- MDL Number:
- MFCD00041225
- MOL File:
- 2369-19-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-Fluoro-5-methylpyridine 97% | 595136 | 1g | $44.4 |
| 2-Fluoro-5-methylpyridine >98.0%(GC) | F0581 | 1g | $22 |
| 2-Fluoro-5-methylpyridine >98.0%(GC) | F0581 | 5g | $70 |
| 2-Fluoro-5-methylpyridine Asreported | 276046 | 10g | $322 |
| 2-Fluoro-5-methylpyridine Asreported | 276046 | 25g | $438 |
| More product size | |||
| Boiling point | 158-159 °C (lit.) |
|---|---|
| Density | 1.072 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 119 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -0.14±0.10(Predicted) |
| form | Liquid |
| Specific Gravity | 1.077 |
| color | Colorless to pale yellow |
| BRN | 107085 |
| InChI | InChI=1S/C6H6FN/c1-5-2-3-6(7)8-4-5/h2-4H,1H3 |
| InChIKey | AOSOZARHUJMBLZ-UHFFFAOYSA-N |
| SMILES | C1(F)=NC=C(C)C=C1 |
| CAS DataBase Reference | 2369-19-9(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi,F | |||||||||
| Risk Statements | 10-36/37/38 | |||||||||
| Safety Statements | 16-26-36/37-36 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Flammable/Irritant | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Flam. Liq. 3 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Fluoro-5-methylpyridine price More Price(75)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 595136 | 2-Fluoro-5-methylpyridine 97% | 2369-19-9 | 1g | $44.4 | 2023-06-20 | Buy |
| TCI Chemical | F0581 | 2-Fluoro-5-methylpyridine >98.0%(GC) | 2369-19-9 | 1g | $22 | 2026-04-30 | Buy |
| TCI Chemical | F0581 | 2-Fluoro-5-methylpyridine >98.0%(GC) | 2369-19-9 | 5g | $70 | 2026-04-30 | Buy |
| Usbiological | 276046 | 2-Fluoro-5-methylpyridine Asreported | 2369-19-9 | 10g | $322 | 2026-06-03 | Buy |
| Usbiological | 276046 | 2-Fluoro-5-methylpyridine Asreported | 2369-19-9 | 25g | $438 | 2026-06-03 | Buy |
2-Fluoro-5-methylpyridine Chemical Properties,Uses,Production
Chemical Properties
liquid
Synthesis
1603-41-4
2369-19-9
To a solution of 2-amino-5-methylpyridine (13) (20.0 g, 185 mmol) in fluoboric acid (50 wt% aqueous solution, 50 mL) was added sodium nitrite (16.6 g, 240 mmol) in batches at -10 °C while controlling the temperature of the reaction to be below 0 °C. After addition, the reaction mixture was stirred at 0 °C for 30 min, then warmed to 50 °C and continued stirring for 30 min. After completion of the reaction, the reaction was cooled to room temperature and the pH was adjusted to 9-10 with saturated aqueous sodium carbonate solution (250 mL), followed by extraction with dichloromethane (4 x 125 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by alumina column chromatography (eluent: dichloromethane) to afford 2-fluoro-5-methylpyridine (14) (7.50 g, 69 mmol) as a yellow oil in 37% yield. Thin-layer chromatography (TLC) analysis: Rf (Al2O3, dichloromethane) 0.92. Infrared spectra (IR, NaCl plate) νmax: 1246, 1379, 1486, 2929 cm-1. nuclear magnetic resonance hydrogen spectra (1H NMR, 200 MHz, CDCl3) δ: 2.25 (s, 3H, CH3), 6.75 (dd, 1H, J = 8.2 Hz, 3JH-F = 3.0 Hz, H-3), 7.52 (m, 1H, H-4), 7.94 (s, 1H, H-6). Nuclear magnetic resonance carbon spectrum (13C NMR, 50 MHz, CDCl3) δ: 17.4 (CH3), 108.8 (d, 2JC-F = 38Hz, C-3), 130.6 (C-5), 141.7 (d, 3JC-F = 8Hz, C-4), 147.2 (d, 3JC-F = 14Hz, C-6), 162.1 (d. 1JC-F = 236Hz, C-2).
References
[1] Journal of Fluorine Chemistry, 2005, vol. 126, # 3, p. 345 - 348
[2] European Journal of Medicinal Chemistry, 2015, vol. 92, p. 818 - 838
[3] Journal of the American Chemical Society, 1949, vol. 71, p. 1125
[4] Journal of Medicinal Chemistry, 1990, vol. 33, # 6, p. 1667 - 1675
[5] Patent: US5583148, 1996, A
2-Fluoro-5-methylpyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
View Lastest Price from 2-Fluoro-5-methylpyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-12-01 | 2-Fluoro-5-methylpyridine
2369-19-9
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-11-18 | 2-Fluoro-5-methylpyridine
2369-19-9
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2025-09-25 | 2-Fluoro-5-methylpyridine
2369-19-9
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd |
-
- 2-Fluoro-5-methylpyridine
2369-19-9
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2-Fluoro-5-methylpyridine
2369-19-9
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Fluoro-5-methylpyridine
2369-19-9
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
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