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2-Chlorothiazole

2-Chlorothiazole structure

CAS No.: 3034-52-4

Chemical Name:: 2-Chlorothiazole

Synonyms: orothiazoL;2-CHLOTHIOZOLE;2-CHLOROTHIAZOLE;2-CHLOROTHIOZOLE;Thiazole, 2-chloro-;2-Chlorothiazole,97%;2-Thiazolyl Chloride;2-Chlorothiazole 96%;2-Chlorothiazole >2-CHLORO-1,3-THIAZOLE

CBNumber:: CB3752078

Molecular Formula:: C3H2ClNS

Molecular Weight:: 119.57

MDL Number:: MFCD00210701

MOL File:: 3034-52-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:16:04

Product description	Number	Pack Size	Price
2-Chlorothiazole >98.0%(GC)	C2471	5g	$41
2-Chlorothiazole >98.0%(GC)	C2471	25g	$122
2-Chloro-1,3-thiazole ≥95% (GC) ≥95%(GC)	230080	1g	$184
2-Chloro-1,3-thiazole ≥95% (GC) ≥95%(GC)	230080	5g	$326
2-Chloro-1,3-thiazole ≥95% (GC) ≥95%(GC)	230080	25g	$941
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2-Chlorothiazole Properties

Melting point	85 °C
Boiling point	145 °C
Density	1.393 g/mL at 25 °C
refractive index	n20/D1.551
Flash point	54℃
storage temp.	Inert atmosphere,2-8°C
solubility	soluble in Ether
form	clear liquid
pka	0.84±0.10(Predicted)
color	Colorless to Almost colorless
InChI	InChI=1S/C3H2ClNS/c4-3-5-1-2-6-3/h1-2H
InChIKey	KLEYVGWAORGTIT-UHFFFAOYSA-N
SMILES	S1C=CN=C1Cl
CAS DataBase Reference	3034-52-4(CAS DataBase Reference)
FDA UNII	TA2DNZ4W48
UNSPSC Code	12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS02,GHS07

Signal word

Danger

Hazard statements

H315-H319-H226-H302-H318-H335

Precautionary statements

P280-P305+P351+P338-P210-P233-P240-P241+P242+P243-P264-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P403+P235-P501-P261-P280a-P304+P340-P405-P501a

Hazard Codes

Xi,Xn

Risk Statements

20/21/22-36/37/38-41-22-10

Safety Statements

23-26-36/37/39-39

RIDADR

1993

WGK Germany

HazardClass

PackingGroup

Ⅲ

HS Code

2934100090

Storage Class

3 - Flammable liquids

Hazard Classifications

Acute Tox. 4 Oral
Eye Dam. 1
Flam. Liq. 3

NFPA 704

	1
2		0

2-Chlorothiazole price More Price(70)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	C2471	2-Chlorothiazole >98.0%(GC)	3034-52-4	5g	$41	2026-04-30	Buy
TCI Chemical	C2471	2-Chlorothiazole >98.0%(GC)	3034-52-4	25g	$122	2026-04-30	Buy
Usbiological	230080	2-Chloro-1,3-thiazole ≥95% (GC) ≥95%(GC)	3034-52-4	1g	$184	2026-06-03	Buy
Usbiological	230080	2-Chloro-1,3-thiazole ≥95% (GC) ≥95%(GC)	3034-52-4	5g	$326	2026-06-03	Buy
Usbiological	230080	2-Chloro-1,3-thiazole ≥95% (GC) ≥95%(GC)	3034-52-4	25g	$941	2026-06-03	Buy

Product number	Packaging	Price	Buy
C2471	5g	$41	Buy
C2471	25g	$122	Buy
230080	1g	$184	Buy
230080	5g	$326	Buy
230080	25g	$941	Buy

2-Chlorothiazole Chemical Properties,Uses,Production

Application

2-Chlorothiazole is a pharmaceutical intermediate that can be prepared from 2-aminothiazole via a diazotization reaction. Literature reports that it can be used to prepare substituted tyrosine inhibitors containing zinc-binding genes, such as N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-(hydroxyamino)-2-oxoethyl)piperidin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide.

Chemical Properties

Pale yellow liquid

Definition

ChEBI: 2-chlorothiazole is a member of 1,3-thiazoles and an organochlorine compound.

Reactivity Profile

Halogen atoms in the 4- and 5-positions of thiazoles exhibit different reactivities depending on the nucleophile: with methoxide ion in methanol the reactivity sequence is 5-chlorothiazole > 2-chlorothiazole > 4-chlorothiazole. In contrast, with thiophenoxide ion or piperidine in methanol, the sequence 2 > 4 > 5 is observed. With the series of alkoxide ions methoxide, ethoxide, isopropoxide and t-butoxide in the corresponding alcohol, the reactivity ratios of 4-chlorothiazole versus 2-chlorothiazole are: 0.07, 0.6, 4, 42. The nucleophilic reactivity of 2-halogenothiazoles is strongly affected by substituents: 2-chloro-5-nitrothiazole is more reactive than 2-chlorothiazole by a factor of 10.

Synthesis

288-47-1

3034-52-4

General procedure for the synthesis of 2-chlorothiazole from thiazole: To an anhydrous THF (60 mL) solution of thiazole (5.0 g, 58.7 mmol) was added n-butyllithium (1.6 M hexane solution, 44 mL, 70.4 mmol) slowly and dropwise over a period of 20 min at -78 °C with stirring. The reaction mixture was kept at 0 °C for 15 min, followed by dropwise addition of anhydrous THF (40 mL) solution of 2,2,2-trichloroacetyl chloride (6.6 mL, 58.7 mmol) to the orange colored mixture. The reaction mixture was continued to be stirred at -78 °C for 30 min, after which the reaction was quenched with saturated ammonium chloride solution (100 mL). After extraction with ether (2 x 150 mL), the organic layers were combined, washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (0-20% ether/pentane gradient elution) to afford the target compound 2-chlorothiazole (4.95 g, isolated yield 71%).1H NMR (400 MHz, CDCl3) δ 7.50 (d, J=4.0 Hz, 1H), 7.15 (d, J=4.0 Hz, 1H).

References

[1] Patent: WO2008/150446, 2008, A1. Location in patent: Page/Page column 29
[2] Journal of Organometallic Chemistry, 1999, vol. 588, # 2, p. 155 - 159
[3] Journal of Organometallic Chemistry, 2000, vol. 601, # 2, p. 233 - 236

2-Chlorothiazole Preparation Products And Raw materials

Raw materials

THIAZOLE N-OXIDE 4-Chlorothiazole Thiazole 2-Aminothiazole Trifluoroacetyl chloride

n-Butyllithium 5-CHLORO-THIAZOLE

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Preparation Products

2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE 2-Chloro-5-methylthiazole N-(2-Chlorophenyl)thiazol-2-amine 2-Thiazoleacetonitrile, -alpha--methyl- 2-p-tolylthiazole

N-cyclohexyl-1,3-thiazol-2-amine N-PHENYL-2-AMINOTHIAZOLE

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2-Chlorothiazole Suppliers

Global( 246)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
JINING XINHE CHEMICAL CO., LTD	+8615318402391	sales@xinhepharma.com	China	809	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20122	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6366	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58

Supplier	Advantage
JINING XINHE CHEMICAL CO., LTD	58
Henan Fengda Chemical Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
Nanjing ChemLin Chemical Industry Co., Ltd.	60
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Shandong chuangyingchemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from 2-Chlorothiazole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-01	2-Chlorothiazole 3034-52-4		1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-09-25	2-Chlorothiazole 3034-52-4	$1.10-32.00	1kg	99%		Henan Fengda Chemical Co., Ltd
2025-05-23	2-Chlorothiazole 3034-52-4	$50.00	1kg	99	5000	Hebei Zhuanglai Chemical Trading Co Ltd

2-Chlorothiazole
3034-52-4
98.0%
Shaanxi Dideu New Materials Co. Ltd

2-Chlorothiazole
3034-52-4
$1.10-32.00
99%
Henan Fengda Chemical Co., Ltd

2-Chlorothiazole
3034-52-4
$50.00
99
Hebei Zhuanglai Chemical Trading Co Ltd

2-Chlorothiazole Spectrum

2-Chlorothiazole(3034-52-4)¹HNMR 2-Chlorothiazole(3034-52-4)FT-IR

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2-CHLOROTHIAZOLE 2-CHLORO-1,3-THIAZOLE 2-CHLOROTHIOZOLE 2-CHLOTHIOZOLE 2-CHLOROTHIAZOLE, 95+% 1-BENZYLPYRROLIDINE-3-CARBOXYAMIDE Thiazole, 2-chloro- 2-Chlorothiazole 96% 2-Thiazolyl Chloride 2-Chlorothiazole,97% orothiazoL 2-Chloro-1,3-thiazole 98% 2-Chlorothiazole > 3034-52-4 3034-53-4 3034-49-3 C3H2ClNS Miscellaneous Heterocycle Thiazoles, Isothiazoles & Benzothiazoles Thiazole series Halides Thiazoles, Isothiazoles &Benzothiazoles Thiazoles, Isothiazoles & Benzothiazoles

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