4-Bromothiophene-2-carboxaldehyde
- CAS No.
- 18791-75-8
- Chemical Name:
- 4-Bromothiophene-2-carboxaldehyde
- Synonyms
- 4-BROMOTHIOPHENE-2-CARBALDEHYDE;4-BROMO-2-THIOPHENECARBALDEHYDE;4-BROMO-2-THIOPHENECARBOXALDEHYDE;TIMTEC-BB SBB000293;4-Bromo-2-thiophene;LABOTEST-BB LT00112358;4-BROMO-2-FORMYLTHIOPHENE;3-Bromo-5-formylthiophene;4-BROMOTHIOPHENE-2-ALDEHYDE;4-Bromthiophen-2-carbaldehyd
- CBNumber:
- CB3771198
- Molecular Formula:
- C5H3BrOS
- Molecular Weight:
- 191.05
- MDL Number:
- MFCD00005431
- MOL File:
- 18791-75-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Bromo-2-thiophenecarboxaldehyde 90% | 283452 | 5g | $59.9 |
| 4-Bromo-2-thiophenecarboxaldehyde 90% | 283452 | 25g | $284 |
| 4-Bromothiophene-2-carboxaldehyde >98.0%(GC) | B2827 | 5g | $31 |
| 4-Bromothiophene-2-carboxaldehyde >98.0%(GC) | B2827 | 25g | $91 |
| 4-Bromothiophene-2-carbaldehyde Asreported | 261728 | 5g | $272 |
| More product size | |||
| Melting point | 44-46 °C (lit.) |
|---|---|
| Boiling point | 114-115 °C/11 mmHg (lit.) |
| Density | 1.770 (estimate) |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | soluble in Methanol |
| form | Powder or Granules |
| color | White to beige |
| Sensitive | Air Sensitive |
| BRN | 108455 |
| InChI | InChI=1S/C5H3BrOS/c6-4-1-5(2-7)8-3-4/h1-3H |
| InChIKey | PDONIKHDXYHTLS-UHFFFAOYSA-N |
| SMILES | C1(C=O)SC=C(Br)C=1 |
| CAS DataBase Reference | 18791-75-8(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 22-24/25-36/37/39-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-23 | |||||||||
| TSCA | N | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
4-Bromothiophene-2-carboxaldehyde price More Price(78)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 283452 | 4-Bromo-2-thiophenecarboxaldehyde 90% | 18791-75-8 | 5g | $59.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | 283452 | 4-Bromo-2-thiophenecarboxaldehyde 90% | 18791-75-8 | 25g | $284 | 2026-04-30 | Buy |
| TCI Chemical | B2827 | 4-Bromothiophene-2-carboxaldehyde >98.0%(GC) | 18791-75-8 | 5g | $31 | 2026-04-30 | Buy |
| TCI Chemical | B2827 | 4-Bromothiophene-2-carboxaldehyde >98.0%(GC) | 18791-75-8 | 25g | $91 | 2026-04-30 | Buy |
| Usbiological | 261728 | 4-Bromothiophene-2-carbaldehyde Asreported | 18791-75-8 | 5g | $272 | 2026-06-03 | Buy |
4-Bromothiophene-2-carboxaldehyde Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Uses
4-Bromothiophene-2-carboxaldehyde has been used:
- as building block for the synthesis of tetrahydroisoquinolinones
- in the synthesis of 3-[(4-bromo-2-thienyl)methylenehydrazinocarbonyl]-1H-1,2,4-triazole
Application
4-Bromothiophene-2-carboxaldehyde is an important and commonly used intermediate in medicinal chemistry.
Synthesis
872-31-1
68-12-2
18791-75-8
930-96-1
General procedure: a THF solution of 1 M NaHMDS (8.8 mL, 8.8 mmol) was slowly added dropwise to the substrate (6.8 mmol) at 0°C. The reaction mixture was stirred for 30 min at 0 °C, then a solution of anhydrous THF (2 mL) with electrophilic reagent (8.3 mmol) was slowly added and stirring was continued for 3 h at 0 °C. Upon completion of the reaction, the reaction was quenched with saturated NH4Cl solution (5 mL) and diluted with hexane (20 mL). The organic layer was separated and washed with 15 wt% NaCl aqueous solution (10 mL) and subsequently concentrated to give the crude product. The product was purified by fast chromatography using a silica gel column pretreated with Et3N and 0.1% Et3N/4.9% EtOAc/95% hexane as eluent.
Toxicity evaluation
4-Bromothiophene-2-carboxaldehyde has acute oral toxicity and acute dermal toxicity, it causes skin corrosion/irritation and serious eye damage/eye irritation.
References
[1] Tetrahedron Letters, 2012, vol. 53, # 2, p. 166 - 169
4-Bromothiophene-2-carboxaldehyde Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Vital Biotechnology Co., Ltd. | +8617860230571 | biotechcaroline@gmail.com | China | 87 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5228 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hebei Miaobian Biotechnology Co., Ltd | +8617733850068 | CHINA | 967 | 58 |
View Lastest Price from 4-Bromothiophene-2-carboxaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-05 | 4-Bromothiophene-2-carboxaldehyde
18791-75-8
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-05-28 | 4-Bromothiophene-2-carboxaldehyde
18791-75-8
|
$9.00 | 1KG | 99.8% | 100tons | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-04-27 | 4-BroMo-2-thiophenecarboxaldehyde
18791-75-8
|
1kg | 98% | 100tons | Shandong Vital Biotechnology Co., Ltd. |
-
- 4-Bromothiophene-2-carboxaldehyde
18791-75-8
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 4-Bromothiophene-2-carboxaldehyde
18791-75-8
- $9.00
- 99.8%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 4-BroMo-2-thiophenecarboxaldehyde
18791-75-8
- 98%
- Shandong Vital Biotechnology Co., Ltd.
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