PD 166793
- CAS No.
- 199850-67-4
- Chemical Name:
- PD 166793
- Synonyms
- PD 166793;PD-166793-0000;PD 166793 USP/EP/BP;MMP-2/MMP-3 Inhibitor;PD-166793, 10 mM in DMSO;MMP-2/MMP-3 Inhibitor III, PD166793;N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine;L-Valine, N-[(4'-bromo[1,1'-biphenyl]-4-yl)sulfonyl]-;(S)-2-(4'-bromobiphenyl-4-ylsulfonamido)-3-methylbutanoic acid;(2S)-2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoicaci
- CBNumber:
- CB3840520
- Molecular Formula:
- C17H18BrNO4S
- Molecular Weight:
- 412.3
- MDL Number:
- MFCD09038565
- MOL File:
- 199850-67-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem | 444284 | 5mg | $270 |
| PD 166793 ≥98% | 23762 | 5mg | $134 |
| PD 166793 ≥98% | 23762 | 10mg | $189 |
| PD 166793 ≥98% | 23762 | 25mg | $432 |
| PD 166793 ≥98% | 23762 | 5mg | $121 |
| More product size | |||
| Melting point | 192-193℃ |
|---|---|
| Density | 1.457 |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml |
| form | A crystalline solid |
| color | White to pink |
| InChI | 1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1 |
| InChIKey | GJOCABIDMCKCEG-INIZCTEOSA-N |
| SMILES | [S](=O)(=O)(N[C@@H](C(C)C)C(=O)O)c1ccc(cc1)c2ccc(cc2)Br |
| FDA UNII | U855L3SOXD |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
PD 166793 price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 444284 | MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem | 199850-67-4 | 5mg | $270 | 2026-04-30 | Buy |
| Cayman Chemical | 23762 | PD 166793 ≥98% | 199850-67-4 | 5mg | $134 | 2026-04-30 | Buy |
| Cayman Chemical | 23762 | PD 166793 ≥98% | 199850-67-4 | 10mg | $189 | 2026-04-30 | Buy |
| Cayman Chemical | 23762 | PD 166793 ≥98% | 199850-67-4 | 25mg | $432 | 2026-04-30 | Buy |
| Cayman Chemical | 23762 | PD 166793 ≥98% | 199850-67-4 | 5mg | $121 | 2024-03-01 | Buy |
PD 166793 Chemical Properties,Uses,Production
Uses
PD 166793 is a matrix metalloproteinase inhibitor in the treatment of inflammatory pathological occurrences involving blood pressure and the cardiac system.
General Description
A cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC50 = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 μM), MMP-1, -7, -9, and -14 (IC50 = 6.1, 7.2, 7.9, and 0.24 μM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.
Biological Activity
Broad spectrum matrix metalloprotease (MMP) inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC 50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.
Biochem/physiol Actions
Cell permeable: yes
storage
Desiccate at +4°C
PD 166793 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29094 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49897 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
