DPO-1
- CAS No.
- 43077-30-1
- Chemical Name:
- DPO-1
- Synonyms
- DPO-1;DOP-1 (Diphenyl phosphine oxide-1);(+)-Neomenthyl diphenylphosphine oxide;inhibit,DPO1,Inhibitor,DPO 1,Potassium Channel,DPO-1,KcsA;((1S,2S,5R)-2-Isopropyl-5-methylcyclohexyl)diphenylphosphine oxide;(1S,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl]diphenyl-phosphine oxide;{[(1S,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl](phenyl)phosphoroso}benzene;Phosphine oxide, [(1S,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]diphenyl-;[1S-(1α,2α,5β)]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphineoxide
- CBNumber:
- CB3850927
- Molecular Formula:
- C22H29OP
- Molecular Weight:
- 340.44
- MDL Number:
- MFCD09038567
- MOL File:
- 43077-30-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| DPO-1 needles, >97% (NMR) | D7443 | 25mg | $853 |
| DPO-1 ≥98% | 29688 | 1mg | $42 |
| DPO-1 ≥98% | 29688 | 5mg | $157 |
| DPO-1 ≥98% | 29688 | 10mg | $250 |
| DPO-1 | 29688 | 1mg | $38 |
| storage temp. | Store at +4°C |
|---|---|
| solubility | DMSO: soluble2mg/mL, clear (warmed) |
| form | needles |
| color | white |
| FDA UNII | H9LQP293GK |
DPO-1 price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D7443 | DPO-1 needles, >97% (NMR) | 43077-30-1 | 25mg | $853 | 2023-06-20 | Buy |
| Cayman Chemical | 29688 | DPO-1 ≥98% | 43077-30-1 | 1mg | $42 | 2026-04-30 | Buy |
| Cayman Chemical | 29688 | DPO-1 ≥98% | 43077-30-1 | 5mg | $157 | 2026-04-30 | Buy |
| Cayman Chemical | 29688 | DPO-1 ≥98% | 43077-30-1 | 10mg | $250 | 2026-04-30 | Buy |
| Cayman Chemical | 29688 | DPO-1 | 43077-30-1 | 1mg | $38 | 2024-03-01 | Buy |
DPO-1 Chemical Properties,Uses,Production
Uses
DPO-1 is a potent inhibitor of the voltage-gated potassium channel subtype Kv1.5 and a blocker of ultrarapid delayed rectifier potassium current. DPO-1 prevents atrial arrhythmia[1][2].
Definition
ChEBI: [[(1S,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]-phenylphosphoryl]benzene is a monoterpenoid.
Biological Activity
Blocker of I Kur ultrarapid delayed rectifier potassium current and K V 1.5 channels (IC 50 = 0.31 μ M for rK V 1.5). Displays selectivity for inhibition of I Kur over I to (8-fold), I K1 , I Kr and I Ks (20-fold) in native myocytes and selectivity for rat recombinant K V 1.5 over K V 3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.
storage
Store at +4°C
References
[1] Lagrutta A, et al. Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapidly activating delayed rectifier potassium current. J Pharmacol Exp Ther. 2006 Jun;317(3):1054-63. DOI:10.1124/jpet.106.101162
[2] Stump GL, et al. In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide. J Pharmacol Exp Ther. 2005 Dec;315(3):1362-7. DOI:10.1124/jpet.105.092197
DPO-1 Preparation Products And Raw materials
Raw materials
Preparation Products
DPO-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | 1059@dideu.com | China | 3703 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4794 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4849 | 55 | |
| Shanghai Chiral bio-compound co., Ltd. | 021-5068 3667/17749785980/1029026415; 17749785980 | 1029026415@qq.com | China | 4359 | 58 |
