guanidine
- CAS No.
- 113-00-8
- Chemical Name:
- guanidine
- Synonyms
- imidourea;Carbamidine;carbamamidine;Guanidine 98%;Guanidinebase;Diaminomethanimine;Ribavirin Impurity T;Guanidine, free base;Metformin Impurity 33;Metformin Impurity 33 Monomer
- CBNumber:
- CB3874769
- Molecular Formula:
- CH5N3
- Molecular Weight:
- 59.07
- MDL Number:
- MOL File:
- 113-00-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Guanidine | FG152479 | 100mg | $3625 |
| Guanidine | FG152479 | 250mg | $6525 |
| Guanidine | FG152479 | 500mg | $8700 |
| Guanidine | FG152479 | 1000mg | $11600 |
| GUANIDINE 95.00% | NUC0000978 | 5G | $909.56 |
| More product size | |||
| Melting point | ~50° |
|---|---|
| Boiling point | 82.3°C (rough estimate) |
| Density | 1.6000 (rough estimate) |
| refractive index | 1.5950 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | pKa ~12.5(at 25℃) |
| color | White |
| FDA 21 CFR | 176.180(Components of paper and paperboard in contact with dry food); 177.1200(Cellophane) |
| Indirect Additives used in Food Contact Substances | GUANIDINE |
| FDA UNII | JU58VJ6Y3B |
| EPA Substance Registry System | Guanidine (113-00-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H410 |
| Precautionary statements | P264-P273-P280-P337+P313-P391-P501 |
| RIDADR | 1759 |
| HazardClass | 8 |
| PackingGroup | II |
| Hazardous Substances Data | 113-00-8(Hazardous Substances Data) |
| Toxicity | LD50 i.p. in mice: 350 mg/kg (Podlesnaya) |
| REACH Registrations | Active |
guanidine price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FG152479 | Guanidine | 113-00-8 | 100mg | $3625 | 2026-06-04 | Buy |
| Biosynth | FG152479 | Guanidine | 113-00-8 | 250mg | $6525 | 2026-06-04 | Buy |
| Biosynth | FG152479 | Guanidine | 113-00-8 | 500mg | $8700 | 2026-06-04 | Buy |
| Biosynth | FG152479 | Guanidine | 113-00-8 | 1000mg | $11600 | 2026-06-04 | Buy |
| American Custom Chemicals Corporation | NUC0000978 | GUANIDINE 95.00% | 113-00-8 | 5G | $909.56 | 2021-12-16 | Buy |
guanidine Chemical Properties,Uses,Production
Chemical Properties
Colorless crystals. Soluble inwater and alcohol. Combustible. Guanidine is a strong monobasic Bronsted base, which absorbs water and carbon dioxide from the air and forms strongly alkaline solutions with water and alcohols; the pH of a 20 wt % aqueous solution is ca. 13.5 (25 ℃). In aqueous solution at elevated temperature guanidine is hydrolyzed to urea; airtight alcohol solutions are stable. Guanidine is infinitely soluble in water, ethanol, methanol, and dimethylformamide.
Uses
Organic synthesis
Uses
Guanidine is an intermediate in synthesizing N-Formylguanidine (F700505), which is used in the preparation of Amiloride (A578700), a sodium channel blocker used as a diuretic drug.
Production Methods
Guanidine is formed (1) by heating ammonium thiocyanate to 180 °C, (2) by ammonolysis of orthocarbonates, C(OC2H5)4 + 3NH3 → (NH2)2C=NH + 4C2H5OH, (3) by ammonolysis of chloropicrin, Cl3CNO2 + 7NH3 → NH2)2 C=NH + 3NH4Cl + N2 + 3H2O, (4) by ammonolysis of cyanogen chloride, ClCN + NH3 → ClC(NH2)=NH → HN=C=NH → (NH2)2 C=NH.
Guanidine forms salts with acids, e.g., guanidine nitrate, HNC(NH2)2 · HNO3. By heating at 120 °C for several hours, a mixture of ammonium thiocyanate and dicyanodiamide, guanidine thiocyanate solution is obtained by extracting with water. Treating guanidine with a mixture of nitric and sulfuric acids forms nitroguanidine which is reduced by zinc and acetic acid to aminoguanidine.
By treating aminoguanidine (1) with dilute acid or alkali, there is obtained, first, semicarbazide, finally hydrazine; (2) with nitrous acid, diazoguanidine which is decomposed by alkali into alkali azide (e.g., NaN3) plus cyanamide (H2N·CN) plus water.
Definition
ChEBI: Guanidine is an aminocarboxamidine, the parent compound of the guanidines. It is a one-carbon compound, a member of guanidines and a carboxamidine. It is a conjugate base of a guanidinium.
Agricultural Uses
Carbamidine is another name for guanidine. It is a crystalline basic compound related to urea. It forms a number of salts which are used as fertilizers. Guanidine phosphate is an example.
Purification Methods
Crystallise it from water/EtOH under nitrogen. It is very deliquescent and absorbs CO2 from the air readily. [Jones Trans Faraday Soc 55 524 1959, Beilstein 3 H 82, 3 I 39, 3 II 69, 3 III 154, 3 IV 148.]
guanidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15083 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9539 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-86-17392712697 +8617792793228 | 1069@dideu.com | China | 8609 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43414 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
