Guanfacine
- CAS No.
- 29110-47-2
- Chemical Name:
- Guanfacine
- Synonyms
- C07037;SPD503;SPD 503;SPD-503;Guanfacine;Guanfacine USP/EP/BP;Guanfacine free base;Guanfacine Solution, 100ppm;[(2,6-Dichlorophenyl)acetyl]guanidine;2-(2,6-Dichlorophenylacetyl)guanidine
- CBNumber:
- CB3875216
- Molecular Formula:
- C9H9Cl2N3O
- Molecular Weight:
- 246.09
- MDL Number:
- MFCD00865944
- MOL File:
- 29110-47-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Guanfacine 99.85% | CS-2787 | 5mg | $41 |
| Guanfacine 99.85% | CS-2787 | 10mg | $65 |
| Guanfacine 99.85% | CS-2787 | 25mg | $130 |
| Guanfacine 99.85% | CS-2787 | 50mg | $208 |
| Guanfacine 99.85% | CS-2787 | 100mg | $320 |
| More product size | |||
| Melting point | 227-230C |
|---|---|
| Density | 1.50±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 11.92±0.46(Predicted) |
| color | White to off-white |
| BCS Class | 1 |
| EWG's Food Scores | 1 |
| FDA UNII | 30OMY4G3MK |
| ATC code | C02AC02 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
Guanfacine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-2787 | Guanfacine 99.85% | 29110-47-2 | 5mg | $41 | 2026-06-04 | Buy |
| ChemScene | CS-2787 | Guanfacine 99.85% | 29110-47-2 | 10mg | $65 | 2026-06-04 | Buy |
| ChemScene | CS-2787 | Guanfacine 99.85% | 29110-47-2 | 25mg | $130 | 2026-06-04 | Buy |
| ChemScene | CS-2787 | Guanfacine 99.85% | 29110-47-2 | 50mg | $208 | 2026-06-04 | Buy |
| ChemScene | CS-2787 | Guanfacine 99.85% | 29110-47-2 | 100mg | $320 | 2026-06-04 | Buy |
Guanfacine Chemical Properties,Uses,Production
Chemical Properties
White Solid
Originator
Estulic,Sandoz,Switz.,1980
Uses
Centrally acting α-adrenoceptor agonist. Antihypertensive.
Uses
Guanfacine centrally acting α-adrenoceptor agonist. Guanfacine is an antihypertensive.
Definition
ChEBI: Guanfacine is a member of acetamides.
Manufacturing Process
2,6-Dichlorophenyl-acetyl-guanidine: A solution of 3.245 g (0.055 mol) of
guanidine in isopropanol is added to a solution of 11.7 g (0.05 mol) of 2,6-
dichlorophenyl-acetic acid ethyl ester (BP 142°C to 143°C/12 mm of Hg) in
20cc of isopropanol. The reaction mixture is allowed to stand overnight and is
subsequently concentrated by evaporation. After recrystallizing the residue
from methanol/ether 2,6-dichlorophenyl-acetyl-guanidine is obtained in the
form of white grains having a MP of 225°C to 227°C.
2,6-Dichlorophenyl-acetyl-guanidine hydrochloride: A solution of 5.6 g (0.025
mol) of 2,-dichlorophenylacetic acid chloride (BP 137°C to 138°C/12 mm of
Hg) in 10 cc of toluene is added dropwise to a mixture of 4.5 g (0.076 mol) of
guanidine and 60 cc of toluene. The reaction mixture is allowed to stand at
room temperature for 20 minutes, is then heated on a steam bath for 2 hours
and is subsequently cooled. The resulting precipitate is filtered off and washed
twice with 25 cc amounts of water in order to separate the guanidine
hydrochloride. The residue (2,6-dichlorophenyl-acetyl-guanidine) is washed
with chloroform for further purification and is then dissolved in 50 cc of
isopropanol. The pH-value of the solution is adjusted to 6 with ethanolic
hydrochloric acid and the solution is cooled. The resulting white needles are
again washed with chloroform. The resulting 2.6-dichlorophenyl-acetylguanidine hydrochloride has a MP of 213°C to 216°C.
brand name
Tenex (Dr. Reddy’s).
Therapeutic Function
Antihypertensive
General Description
Guanfacine is more selective for 2-receptors than isclonidine. Their mechanism of action is the same as that ofclonidine. Differences between clonidine and its twoanalogs are seen in their elimination half-life values and intheir metabolism and urinary excretion patterns. The eliminationhalf-life of clonidine ranges from 20 to 25 hours,whereas that for guanfacine is about 17 hours. Guanabenzhas the shortest DOA of these three agents, with a half-lifeof about 6 hours. Clonidine and guanfacine are excretedunchanged in the urine to the extent of 60% and 50%,respectively. Very little of guanabenz is excreted unchangedin the urine.
Synthesis
Guanfacin, N-amidino-2-(2,6-dichlorophenyl)acetamide (22.3.2), is also synthesized in a very easy synthesis of reacting the acid chloride or ester of 2,6- dichlorophenylacetic acid with guanidine.
Guanfacine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | 1059@dideu.com | China | 3587 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3991 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20725 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Wuhan Han Sheng New Material Technology Co.，Ltd | +8617798174412 | admin01@hsnm.com.cn | China | 2097 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 9949 | 58 |
View Lastest Price from Guanfacine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-20 | Guanfacine
29110-47-2
|
$110.00-290.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2025-12-12 | Guanfacine
29110-47-2
|
$1.00-4.00 | 1KG | 99% | 1KG 100K | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-12-01 | Guanfacine
29110-47-2
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- Guanfacine
29110-47-2
- $110.00-290.00
- TargetMol Chemicals Inc.
-
- Guanfacine
29110-47-2
- $1.00-4.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Guanfacine
29110-47-2
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
