1-N-Boc-5-oxo-1,4-diazepane
- CAS No.
- 190900-21-1
- Chemical Name:
- 1-N-Boc-5-oxo-1,4-diazepane
- Synonyms
- ic Acid Tert-ButyL;N-Boc-1,4-diazepan-5-one;1-Boc-1,4-diazepan-5-one;N1-BOC-5-oxo-1,4-diazepane;1-N-Boc-5-oxo-1,4-Diazepane;5-Oxo-[1,4]Diazepane-1-CarboxyL;1,4-Diazepan-5-one, N1-Boc protected;Homopiperazin-5-one, N1-BOC protected;tert-Butyl-5-oxo-1,4-diazepan-1-carboxylat;5-Oxo-[1,4]diazepane-1-carboxylic acid tert-butyl ester
- CBNumber:
- CB3946990
- Molecular Formula:
- C10H18N2O3
- Molecular Weight:
- 214.26
- MDL Number:
- MFCD04115319
- MOL File:
- 190900-21-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Homopiperazin-5-one, N1-BOC protected >97% | OR45003 | 1g | $21 |
| Homopiperazin-5-one, N1-BOC protected >97% | OR45003 | 5g | $52 |
| Homopiperazin-5-one, N1-BOC protected >97% | OR45003 | 25g | $204 |
| Homopiperazin-5-one, N1-BOC protected >97% | OR45003 | 100g | $811 |
| 5-Oxo-[1,4]diazepane-1-carboxylic acid tert-butyl ester 98%(HPLC) | W4101 | 250mg | $16 |
| More product size | |||
| Boiling point | 373.1±35.0 °C(Predicted) |
|---|---|
| Density | 1.098±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 16.06±0.20(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C10H18N2O3/c1-10(2,3)15-9(14)12-6-4-8(13)11-5-7-12/h4-7H2,1-3H3,(H,11,13) |
| InChIKey | GLJYPTWEXBUATJ-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC(=O)NCC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| HazardClass | IRRITANT |
| HS Code | 2933998090 |
1-N-Boc-5-oxo-1,4-diazepane price More Price(79)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR45003 | Homopiperazin-5-one, N1-BOC protected >97% | 190900-21-1 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR45003 | Homopiperazin-5-one, N1-BOC protected >97% | 190900-21-1 | 5g | $52 | 2026-06-04 | Buy |
| Apolloscientific | OR45003 | Homopiperazin-5-one, N1-BOC protected >97% | 190900-21-1 | 25g | $204 | 2026-06-04 | Buy |
| Apolloscientific | OR45003 | Homopiperazin-5-one, N1-BOC protected >97% | 190900-21-1 | 100g | $811 | 2026-06-04 | Buy |
| AK Scientific | W4101 | 5-Oxo-[1,4]diazepane-1-carboxylic acid tert-butyl ester 98%(HPLC) | 190900-21-1 | 250mg | $16 | 2026-06-04 | Buy |
1-N-Boc-5-oxo-1,4-diazepane Chemical Properties,Uses,Production
Uses
1-N-Boc-5-oxo-1,4-diazepane is a 1,4-diazepane derivatives compound，used as sigma receptor ligands in antipsychotics, antiamnesics, and against other neurodegenerative disorders as well as neuroprotective agents.[1]
Synthesis
150008-24-5
190900-21-1
The general procedure for the synthesis of N-Boc-1,4-diaza-5-cycloheptanone from 4-oxime-1-Boc-piperidine was as follows: to a solution of tetrahydrofuran (THF, 10 mL) containing the ketoxime (0.01 mol) was added T3P (15 mol%, 50% solution in ethyl acetate). The reaction mixture was stirred at reflux for 1-4 h under nitrogen protection. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the solvent was removed under reduced pressure. The residue was diluted with distilled water (20 mL) and subsequently extracted with ethyl acetate (2 x 20 mL). The organic phases were combined and washed sequentially with saturated sodium bicarbonate (NaHCO3) solution (1 × 10 mL) and brine. The organic phase was dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give a high purity target amide product.
References
[1] Daniele Zampieri*. “Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands.” ACS Medicinal Chemistry Letters 11 5 (2019): 651–656.
1-N-Boc-5-oxo-1,4-diazepane Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2165 | 58 |
| Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 722 | 55 | |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| KARMEL TECHNOLOGY (HK) CO.,LIMITED | +8618795957998 | karmelhk@126.com | CHINA | 2886 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
View Lastest Price from 1-N-Boc-5-oxo-1,4-diazepane manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-19 | tert-Butyl-5-oxo-1,4-diazepan-1-carboxylat
190900-21-1
|
$3.00 | 1KG | 99% | 1kg,5kg,50kg | Career Henan Chemical Co |
-
- tert-Butyl-5-oxo-1,4-diazepan-1-carboxylat
190900-21-1
- $3.00
- 99%
- Career Henan Chemical Co
