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ChemicalBook >> CAS DataBase List >>PUROMYCIN DIHYDROCHLORIDE

PUROMYCIN DIHYDROCHLORIDE

CAS No.
58-58-2
Chemical Name:
PUROMYCIN DIHYDROCHLORIDE
Synonyms
pdh;PUROMYCIN;PUROMYCIN 2HCL;l-2hc;abs9143;Purinomycin;-9H-purin-9-yl);Puromycin dihydrochL;P638 dihydrochloride;-5-(6-(dimethylamino)
CBNumber:
CB4152905
Molecular Formula:
C22H30ClN7O5
Molecular Weight:
507.98
MDL Number:
MFCD00012691
MOL File:
58-58-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-03 11:24:09
Product description Number Pack Size Price
Puromycin dihydrochloride from Streptomyces alboniger ≥98% (HPLC), powder P7255 25mg $95.2
Puromycin dihydrochloride from Streptomyces alboniger ≥98% (HPLC), powder P7255 1g $2170
Puromycin ready made solution 10 mg/mL in H2O, ≥98% (HPLC), Cell culture tested P4512 10 x 1 mL $221
Puromycin, Dihydrochloride, Cell Culture-Tested - CAS 58-58-2 - Calbiochem Puromycin, CAS 58-58-2, is a protein synthesis inhibitor that causes premature release of nascent polypeptide chains. 540411 25MG $92.2
Puromycin, Dihydrochloride, Cell Culture-Tested - CAS 58-58-2 - Calbiochem Puromycin, CAS 58-58-2, is a protein synthesis inhibitor that causes premature release of nascent polypeptide chains. 540411 100MG $280
More product size

PUROMYCIN DIHYDROCHLORIDE Properties

Melting point 168-170℃
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility H2O: soluble50mg/mL (Sterilize stock solution by filtration using 0.22 μm filter then store in aliquots at 20 °C.)
form solution
color yellow-white
Water Solubility Soluble in water
Merck 14,7943
BRN 3853613
Stability Stable. Heat sensitive. Incompatible with strong oxidizing agents.
InChIKey MKSVFGKWZLUTTO-NGOAXYITSA-N
SMILES O[C@@H]1[C@@H]([C@@H](CO)O[C@H]1N1C=NC2C(=NC=NC1=2)N(C)C)NC(=O)[C@@H](N)CC1C=CC(OC)=CC=1.Cl |&1:1,2,3,7,23,r|
FDA UNII PGN54228S5
EPA Substance Registry System Adenosine, 3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-, dihydrochloride (58-58-2)
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn
Risk Statements  22-40
Safety Statements  24/25
RIDADR  3249
WGK Germany  3
RTECS  AU7355000
F  3-8-10
HazardClass  6.1(b)
PackingGroup  III
HS Code  29419090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Toxicity LD50 oral in guinea pig: 600mg/kg
NFPA 704
0
1 0

PUROMYCIN DIHYDROCHLORIDE price More Price(109)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P7255 Puromycin dihydrochloride from Streptomyces alboniger ≥98% (HPLC), powder 58-58-2 25mg $95.2 2026-04-30 Buy
Sigma-Aldrich P7255 Puromycin dihydrochloride from Streptomyces alboniger ≥98% (HPLC), powder 58-58-2 1g $2170 2026-04-30 Buy
Sigma-Aldrich P4512 Puromycin ready made solution 10 mg/mL in H2O, ≥98% (HPLC), Cell culture tested 10 x 1 mL $221 2026-04-30 Buy
Sigma-Aldrich 540411 Puromycin, Dihydrochloride, Cell Culture-Tested - CAS 58-58-2 - Calbiochem Puromycin, CAS 58-58-2, is a protein synthesis inhibitor that causes premature release of nascent polypeptide chains. 58-58-2 25MG $92.2 2022-05-15 Buy
Sigma-Aldrich 540411 Puromycin, Dihydrochloride, Cell Culture-Tested - CAS 58-58-2 - Calbiochem Puromycin, CAS 58-58-2, is a protein synthesis inhibitor that causes premature release of nascent polypeptide chains. 58-58-2 100MG $280 2022-05-15 Buy
Product number Packaging Price Buy
P7255 25mg $95.2 Buy
P7255 1g $2170 Buy
P4512 10 x 1 mL $221 Buy
540411 25MG $92.2 Buy
540411 100MG $280 Buy

PUROMYCIN DIHYDROCHLORIDE Chemical Properties,Uses,Production

Description

Puromycin (58-58-2) is an aminonucleoside antibiotic derived from Streptomyces alboniger. It is a protein synthesis inhibitor that disrupts peptide transfer on ribosomes causing premature chain termination.1 It is an inhibitor of dipeptidyl-peptidase II and cytosolic alanyl aminopeptidase.2 Puromycin also inhibits protein transport in mitochondria.3

Chemical Properties

white powder

Uses

Puromycin dihydrochloride is the salt of puromycin, a nucleoside antibiotic isolated from Streptomyces alboniger in the 1950s as an anti-trypansomal agent with antibiotic activity. While the salt shares the same pharmacological properties as puromycin free base, its greater water solubility offers advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems, the free base and salt may behave differently.

Uses

Research tool for studying protein synthesis; cell line selection agent in gene transfer experiments.

Uses

Puromycin is an aminonucleoside antibitotic. Puromycin acts as a protein synthesis inhibitor which interferes with translation by inhibiting ribosome functions. Puromycin is also a reversible inhibitor of dipeptidyl-peptidase II (serine peptidase) and cytosol alanyl aminopeptidase.

Uses

An aminonuclease antibiotic used for selection and maintenance of cell lines expressing a transfected pac gene.

Uses

antibacterial

Uses

Puromycin dihydrochloride is a salt of puromycin, a nucleoside antibiotic isolated from Streptomyces alboniger in the 1950s as an anti-trypansomal agent with antibiotic activity. While the salt shares the same pharmacological properties as puromycin free base, its greater water solubility offers advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems, the free base and salt may behave differently.

General Description

White powder.

Air & Water Reactions

Water soluble.

Reactivity Profile

PUROMYCIN DIHYDROCHLORIDE is sensitive to prolonged exposure to heat. . Behaves as a very weak acid in solution.

Fire Hazard

Flash point data for PUROMYCIN DIHYDROCHLORIDE are not available, but PUROMYCIN DIHYDROCHLORIDE is probably combustible.

storage

-20°C

Purification Methods

Puromycin dihydrochloride is purified by recrystallisation from H2O. The free base, [58-60-6] M 294.3, has m 175.5-177o (172-173o) (from H2O). The sulfate has m 180-187o dec (from H2O), and the picrate monohydrate has m 146-149o (from H2O). [Baker et al. J Am Chem Soc 77 1 1955, Fryth et al. J Am Chem Soc 80 3736 1958.] It is an inhibitor of aminopeptidase and terminates protein synthesis [Reboud et al. Biochemistry 20 5281 1981]. [Beilstein 26 III/IV 3704.]

Background

Puromycin Dihydrochloride is hydrochloride salt that is part of the antibiotic puromycin, originally isolated from the bacterium Streptomyces alboniger. The clinical use of puromycin as an antibiotic has been limited as it is non-selective and highly toxic. Instead, puromycin has been used to study mechanisms of protein synthesis as it associates with growing polypeptide chains and causes premature chain termination. The structure of puromycin is analogous to the 3’ end of aminoacyl-tRNA, which allows puromycin to compete with aminoacyl-tRNA for binding at the A’ site of the peptidyl transferase center during protein translation. Puromycin binding results in premature chain release from the ribosome and a truncated, puromycylated polypeptide. As these puromycylated nascent polypeptide chains can be detected using anti-puromycin antibodies, incorporation of puromycin into newly synthesized proteins has been used to estimate the rate and localization of protein synthesis. The use of puromycin labeling to estimate protein synthesis may be limited by cell conditions; similar limits are seen in studies using puromycin to localize areas of protein synthesis.

References

[1] M E AZZAM  I D A. Mechanism of puromycin action: fate of ribosomes after release of nascent protein chains from polysomes.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1973, 70 12: 3866-3869. DOI:10.1073/pnas.70.12.3866
[2] N BHUTANI A L G P Venkatraman. Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation.[J]. The EMBO Journal, 2007: 1385-1396. DOI:10.1038/sj.emboj.7601592
[3] JEANNIE PRICE  Keith V. Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction[J]. Biochimica et biophysica acta. Biomembranes, 1993, 1150 1: Pages 89-97. DOI:10.1016/0005-2736(93)90125-j

PUROMYCIN DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 492)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19936 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10236 58
HONG KONG IPURE BIOLOGY CO.,LIMITED 		86 18062405514 18062405514 ada@ipurechemical.com CHINA 3461 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 9996 58
AFINE CHEMICALS LIMITED 		+86-571-85134551 info@afinechem.com China 15083 58
Baoji Guokang Healthchem Co., Ltd. 		+86-0917-3909592 +86-13892490616 gksales1@gk-bio.com China 9069 58

View Lastest Price from PUROMYCIN DIHYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Puromycin dihydrochloride pictures 2026-06-03 Puromycin dihydrochloride
58-58-2
 $37.00-116.00 99.97% 10g TargetMol Chemicals Inc.
PUROMYCIN DIHYDROCHLORIDE pictures 2025-12-01 PUROMYCIN DIHYDROCHLORIDE
58-58-2
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
PUROMYCIN DIHYDROCHLORIDE pictures 2021-07-13 PUROMYCIN DIHYDROCHLORIDE
58-58-2
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
Puromycin dihydrochloride hydrate,99% 3’-(alpha-amino-p-methoxyhydrocinnamamido)-3’-deoxy-n,n-dimethyl-adenosin adenosine,3’-((2-amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3’-deoxy-n,n-dim dihydrochloride,(s)-ethyl PUROMYCIN Dihydrochloride Dihydrate 96% 3'-[[12-AMINO-3-(4-METHOXYPHENYL)-1-OXOPROPYL]AMINO]-3'-DEOXY-N,N-DIMETHYL-ADENOSINE 2HCL 3'-[[2-AMINO-3-(4-METHOXYPHENYL)-1-OXOPROPYL]AMINO]-3'-DEOXY-N,N-DIMETHYLADENOSINE DIHYDROCHLORIDE 3'-[[2-AMINO-3-(4-METHOXYPHENYL)-1-OXOPROPYL]AMINO]-3'-DEOXY-N,N-DIMETHYL-ADENOSINE 2HCL 3'-(A-AMINO-P-METHOXYHYDROCINNAMAMIDO)-3'-DEOXY-N,N-DIMETHYLADENOSINE DIHYDROCHLORIDE 3'-(A-AMINO-P-METHOXY-HYDOCINNAMAMIDO)-3'-DEXOY-N,N-DIMETHYLADENOSINE 2HCL 3'-(ALPHA-AMINO-P-METHOXY-HYDROCINNAMINO-3'-DEOXY-N,N-DIMETHY-ADENOSINE) 2HCL 3'-(ALPHA-AMINO-P-METHOXY-HYDROCINNAMIDO-3'-DEOXY-N,N-DIMETHYL-ADENOSINE) 2HCL 3'-[ALPHA-AMINO-P-METHOXYHYDROCINNAMAMIDO]-3'-DEOXY-N,N-DIMETHYLADENOSINE DIHYDROCHLORIDE 3'-(ALPHA-AMINO-P-METHOXYHYDROCINNAMAMIDO)-3'-DEOXY-N,N-DIMETHYLADENOSINE, 2HCL 3'-(ALPHA-AMINO-P-METHOXYHYDROCINNAMADIO)-3'-DEOXY-N,N-DIMETHYLADENOSINE DIHYDROCHLORIDE PUROMYCIN, CELL CULTURE TESTED Puromycin, 3-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3-deoxy-N,N-dimethyladenosine dihydrochloride Puromycin hydrate dihydrochloride PuroMycin dihydrochloride hydrate, 99% 10MG PuroMycin dihydrochlorid Puromycin dihydrochloride (animal free) StyloMycin dihydrochloride, CL 13900 dihydrochloride, CL16536, NSC 3055, P638 dihydrochloride. 3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-adenosine,hydrochloride (1:2) Puromycin 2HCl (S)-3'-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine dihydrochloride Puromycin dihydrochloride (S)-3'-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine dihydrochloride Puromycin 2hydrochloride -2-Amino-N-((2S,3S,4R,5R) -4-hydroxy-2-(hydroxymethyl) -5-(6-(dimethylamino) -9H-purin-9-yl) propanamide dihydrochloride tetrahydrofuran-3-yl) PUROMYCIN DIHYDROCHLORIDE (S) 3'-[[2-AMINO-3-(4-METHOXYPHENYL)-1-OXOPROPYL]AMINO]-3'-DEOXY-N,N-DIMETHYLADENOSINE 2HCL (S)-3'-[2-AMINO-3-(4-METHOXYPHENYL)-1-OXOPROPYL]AMINO]-3'-DEOXY-N,N-DIMETHYLADENOSINE l-2hc puromycinhydrochloride stylomycinhydrochloride PUROMYCIN DIHYDROCHLORIDE CELL*CULTURE T ESTED PUROMYCIN READY MADE SOLUTION PUROMYCIN DIHYDROCHLORIDE FROM STREPTO-M YCES ALBO-NIGER (S)-3'-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine dihydrochloride PUROMYCIN DIHYDROCHLORIDE CELL CULTURE REAGENT PUROMYCIN DIHYDROCHLORIDE ULTRA PURE GRADE 98+% Puromycin.Cellculturedtested Puromycin,Solution,CellCultureTested Adenosine, 3-(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropylamino-3-deoxy-N,N-dimethyl-, dihydrochloride 3'-[α-amino-p-methoxyhydrocinnamamido]-3'-deoxy-n,n-dimethyladenosine dihydrochloride PUROMYCINDIHYROCHLORIDE DIHYDROGEN PUROMYCIN DICHLORIDE Puromycin dihydrochL CL 13900 dihydrochloride P638 dihydrochloride STYLOMYCIN HYDROCHLORIDE; CL 13900 DIHYDROCHLORIDE; CL16536; NSC 3055; P638 DIHYDROCHLORIDE PUROMYCIN DIHYDROCHLORIDE USP/EP/BP abs9143 (S)-2-Amino-N-((2S,3S,4R,5R)-5-(6-(Dimethylamino)-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)-3-(4-methoxyphenyl)propanamide dihydrochloride Puromycin 2HCl (CL13900)
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