2-Fluorophenylboronic acid
- CAS No.
- 1993-03-9
- Chemical Name:
- 2-Fluorophenylboronic acid
- Synonyms
- 2-Fluorophenylboronic;2-Flurorphenylboronic acid;2-FLUOROBENZENEBORONIC ACID;AKOS BRN-0104;2-fluoroborate;RARECHEM AH PB 0215;2-Fluorophenylboroni;o-Fluorphenylborsaeure;Tavaborole Impurity 30;uorobenzeneboronic acid
- CBNumber:
- CB4153982
- Molecular Formula:
- C6H6BFO2
- Molecular Weight:
- 139.92
- MDL Number:
- MFCD00674013
- MOL File:
- 1993-03-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-Fluorophenylboronic acid ≥95% | 445223 | 1g | $73.2 |
| 2-Fluorophenylboronic acid ≥95% | 445223 | 10g | $657 |
| 2-Fluorophenylboronic Acid (contains varying amounts of Anhydride) | F0407 | 1g | $25 |
| 2-Fluorophenylboronic Acid (contains varying amounts of Anhydride) | F0407 | 5g | $72 |
| 2-Fluorophenylboronic acid Asreported | 276070 | 5g | $365 |
| More product size | |||
| Melting point | 101-110 °C (lit.) |
|---|---|
| Boiling point | 267.8±42.0 °C(Predicted) |
| Density | 1.24±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | Crystalline Powder |
| pka | 8.32±0.58(Predicted) |
| color | White to light yellow |
| BRN | 3030413 |
| InChI | InChI=1S/C6H6BFO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4,9-10H |
| InChIKey | QCSLIRFWJPOENV-UHFFFAOYSA-N |
| SMILES | B(C1=CC=CC=C1F)(O)O |
| CAS DataBase Reference | 1993-03-9(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 37/39-26-36/37/39-27-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29319090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
2-Fluorophenylboronic acid price More Price(101)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 445223 | 2-Fluorophenylboronic acid ≥95% | 1993-03-9 | 1g | $73.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | 445223 | 2-Fluorophenylboronic acid ≥95% | 1993-03-9 | 10g | $657 | 2026-04-30 | Buy |
| TCI Chemical | F0407 | 2-Fluorophenylboronic Acid (contains varying amounts of Anhydride) | 1993-03-9 | 1g | $25 | 2026-04-30 | Buy |
| TCI Chemical | F0407 | 2-Fluorophenylboronic Acid (contains varying amounts of Anhydride) | 1993-03-9 | 5g | $72 | 2026-04-30 | Buy |
| Usbiological | 276070 | 2-Fluorophenylboronic acid Asreported | 1993-03-9 | 5g | $365 | 2026-06-03 | Buy |
2-Fluorophenylboronic acid Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystalline powder
Uses
Used for the preparation of biologically active biphenyls and arylboron difluoride Lewis acids.
Uses
suzuki reaction
Uses
2-Fluorophenylboronic Acid, is used in Rh-catalyzed enantioselective addition reactions, and Rhodium and Palladium-catalyzed substitution reactions. It can also be used in the preparation of phenylboronic catechol esters as promising anion receptors for polymer electrolytes.
Synthesis
1072-85-1
1993-03-9
The general procedure for the synthesis of 2-fluorophenylboronic acid from o-bromofluorobenzene was as follows: 10.0 g (57.1 mmol) of 1-bromo-2-fluorobenzene and anhydrous tetrahydrofuran were added to a reaction flask and the mixture was subsequently cooled to -70 °C. At -70 °C, 44.2 ml (68.5 mmol) of 1.55 M n-butyllithium solution was slowly added dropwise to the reaction mixture. The temperature was maintained at -70 °C and stirring of the reaction mixture was continued for 1.5 hours. Subsequently, 21.5 g (114.2 mmol) of triisopropyl borate was added dropwise and the reaction temperature was gradually raised to room temperature and stirring was continued for 4 hours. Upon completion of the reaction, aqueous hydrochloric acid was added to the reaction mixture and extracted with dichloromethane. The organic phases were combined and the solvent was removed by distillation under reduced pressure to give the crude product of 2-fluorophenylboronic acid. The crude product was purified by column chromatography (eluent: hexane/acetone) to give 4.8 g (yield: 61%) of pure 2-fluorophenylboronic acid.
References
[1] Patent: US2012/273770, 2012, A1. Location in patent: Page/Page column 24
[2] Patent: US2004/6076, 2004, A1. Location in patent: Page 15
[3] Journal of Organic Chemistry, 2013, vol. 78, # 13, p. 6427 - 6439
2-Fluorophenylboronic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| Hebei Jingbo New Material Technology Co., Ltd | +8619931165850 | hbjbtech@163.com | China | 1000 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Springchem New Material Technology Co.,Limited | +86-021-62885108 +8613917661608 | info@spring-chem.com | China | 2068 | 57 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
View Lastest Price from 2-Fluorophenylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-25 | 2-Fluorophenylboronic acid
1993-03-9
|
$30.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2024-11-07 | 2-Fluorophenylboronic acid
1993-03-9
|
$5.00 | 1kg | 99% | 200000 | Hebei Jingbo New Material Technology Co., Ltd | |
 |
2022-10-09 | 2-Fluorophenylboronic acid
1993-03-9
|
$30.00-150.00 | 100Kg | 99.0% up | 50 tons per month | Xinxiang Hongqi District Houyuan Trading Co.,Ltd
|
-
- 2-Fluorophenylboronic acid
1993-03-9
- $30.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-Fluorophenylboronic acid
1993-03-9
- $5.00
- 99%
- Hebei Jingbo New Material Technology Co., Ltd
-
- 2-Fluorophenylboronic acid
1993-03-9
- $30.00-150.00
- 99.0% up
- Xinxiang Hongqi District Houyuan Trading Co.,Ltd
