4-Fluoro-2-methylbenzonitrile
- CAS No.
- 147754-12-9
- Chemical Name:
- 4-Fluoro-2-methylbenzonitrile
- Synonyms
- 4-Fluoro-2-methylben;Alogliptin Impurity 84;Trelagliptin Impurity 58;Methyl-4-fluorobenzonitrile;2-METHYL-4-FLUOROBENZONITRILE;4-FLUORO-2-METHYLBENZONITRILE;2-Methy-4-Fluoro benzonitrile;Benzonitrile, 4-fluoro-2-methyl-;4-Fluoro-2-methylbenzonitrile >4-Fluoro-2-methylbenzonitrile,97%
- CBNumber:
- CB4167413
- Molecular Formula:
- C8H6FN
- Molecular Weight:
- 135.14
- MDL Number:
- MFCD03095106
- MOL File:
- 147754-12-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Fluoro-2-methylbenzonitrile 97% | 594660 | 5g | $156 |
| 4-Fluoro-2-methylbenzonitrile >99.0%(GC) | F0962 | 1g | $31 |
| 4-Fluoro-2-methylbenzonitrile >99.0%(GC) | F0962 | 5g | $122 |
| 4-Fluoro-2-methylbenzonitrile ≥95% | PC1841 | 5g | $21 |
| 4-Fluoro-2-methylbenzonitrile ≥95% | PC1841 | 25g | $24 |
| More product size | |||
| Melting point | 70-74 °C (lit.) |
|---|---|
| Boiling point | 214.6±20.0 °C(Predicted) |
| Density | 1.11±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to crystal |
| color | White to Almost white |
| InChI | InChI=1S/C8H6FN/c1-6-4-8(9)3-2-7(6)5-10/h2-4H,1H3 |
| InChIKey | BJBXUIUJKPOZLV-UHFFFAOYSA-N |
| SMILES | C(#N)C1=CC=C(F)C=C1C |
| CAS DataBase Reference | 147754-12-9(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN3439 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29269090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Fluoro-2-methylbenzonitrile price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 594660 | 4-Fluoro-2-methylbenzonitrile 97% | 147754-12-9 | 5g | $156 | 2023-06-20 | Buy |
| TCI Chemical | F0962 | 4-Fluoro-2-methylbenzonitrile >99.0%(GC) | 147754-12-9 | 1g | $31 | 2026-04-30 | Buy |
| TCI Chemical | F0962 | 4-Fluoro-2-methylbenzonitrile >99.0%(GC) | 147754-12-9 | 5g | $122 | 2026-04-30 | Buy |
| Apolloscientific | PC1841 | 4-Fluoro-2-methylbenzonitrile ≥95% | 147754-12-9 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC1841 | 4-Fluoro-2-methylbenzonitrile ≥95% | 147754-12-9 | 25g | $24 | 2026-06-04 | Buy |
4-Fluoro-2-methylbenzonitrile Chemical Properties,Uses,Production
Chemical Properties
White to light yellow crystalline powder
Uses
As organic intermediate, pharmaceutical intermediate. In chemical synthesis.
Synthesis
80141-91-9
147754-12-9
The general procedure for the synthesis of 4-fluoro-2-methylbenzonitrile from 4-fluoro-2-methylbenzenemethanol was as follows: in a 25 mL Schlenk tube equipped with a magnetic stirrer, CuCl (0.05 mmol, 5 mol%), DABCO (0.10 mmol, 10 mol%) and 4-HO-TEMPO (0.05 mmol, 5 mol%). Subsequently, a solution of acetonitrile (2 mL) with 4-fluoro-2-methylbenzenemethanol (1 mmol) and an aqueous ammonia solution (25-28%, 3 mmol, 3.0 equiv) was added. The reaction mixture was stirred at room temperature under argon protection for 24 h. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was diluted with water and extracted with ethyl acetate. The organic layers were combined and dried with anhydrous magnesium sulfate. Subsequently, the organic layer was concentrated under reduced pressure and the crude product was purified by column chromatography to afford the target product 4-fluoro-2-methylbenzonitrile.
References
[1] Organic Letters, 2013, vol. 15, # 8, p. 1850 - 1853
[2] Chinese Chemical Letters, 2018, vol. 29, # 3, p. 464 - 466
4-Fluoro-2-methylbenzonitrile Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6366 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2165 | 58 |
View Lastest Price from 4-Fluoro-2-methylbenzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 4-Fluoro-2-methylbenzonitrile
147754-12-9
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2024-04-25 | 4-Fluoro-2-methylbenzonitrile
147754-12-9
|
$30.00-100.00 | 1kg | 99.93% | 1000kg per week | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2022-02-09 | 4-Fluoro-2-methylbenzonitrile
147754-12-9
|
1KG | 97.5% | 100 tons | Honest Joy Holdings Limited
|
-
- 4-Fluoro-2-methylbenzonitrile
147754-12-9
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4-Fluoro-2-methylbenzonitrile
147754-12-9
- $30.00-100.00
- 99.93%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- 4-Fluoro-2-methylbenzonitrile
147754-12-9
- $0.00
- 97.5%
- Honest Joy Holdings Limited
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