ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE
- CAS No.
- 22900-83-0
- Chemical Name:
- ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE
- Synonyms
- ETHYL 2-BROMO-4-METHYLTHIAZOLE-5-CARBOXYLATE;2-bromo-4-methylthiazole-5-carboxylate;ETHYL 2-BROMO-4-METHYLTHIAZOLE-5-CARBOX&;Ethyl 2-bromo-4-methylthiazol-5-carboxylate;Ethyl 2-Bromo-4-methyl-5-thiazolecarboxylate;Ethyl 2-broMo-4-Methylthiazole-5-carboxylate 97%;Ethyl 2-Bromo-4-methylthiazole-5-carboxylate >Ethyl 2-bromop4-methyl-1,3-thiazole-5-carboxylate;ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE;2-Bromo-4-methyl-5-thiazolecarboxylic acid ethyl ester
- CBNumber:
- CB4205566
- Molecular Formula:
- C7H8BrNO2S
- Molecular Weight:
- 250.11
- MDL Number:
- MFCD03791227
- MOL File:
- 22900-83-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Ethyl 2-bromo-4-methylthiazole-5-carboxylate 97% | 645990 | 1g | $54.1 |
| Ethyl 2-bromo-4-methylthiazole-5-carboxylate 97% | 645990 | 5g | $207 |
| Ethyl 2-Bromo-4-methylthiazole-5-carboxylate >97.0%(GC) | E0945 | 1g | $41 |
| Ethyl 2-Bromo-4-methylthiazole-5-carboxylate >97.0%(GC) | E0945 | 5g | $132 |
| Ethyl 2-bromo-4-methylthiazole-5-carboxylate | FE32887 | 50g | $150 |
| More product size | |||
| Melting point | 65-69 °C(lit.) |
|---|---|
| Boiling point | 287.1±20.0 °C(Predicted) |
| Density | 1.573±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | -0.10±0.10(Predicted) |
| form | powder to crystal |
| color | Light yellow to Brown |
| Water Solubility | Insoluble in water. |
| InChI | InChI=1S/C7H8BrNO2S/c1-3-11-6(10)5-4(2)9-7(8)12-5/h3H2,1-2H3 |
| InChIKey | CFBIOWPDDZPIDP-UHFFFAOYSA-N |
| SMILES | S1C(C(OCC)=O)=C(C)N=C1Br |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H317-H318-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 37/38-41 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 1759 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29341000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Dam. 1 Skin Irrit. 2 Skin Sens. 1 STOT SE 3 |
|||||||||
| NFPA 704 |
|
ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE price More Price(84)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 645990 | Ethyl 2-bromo-4-methylthiazole-5-carboxylate 97% | 22900-83-0 | 1g | $54.1 | 2023-01-07 | Buy |
| Sigma-Aldrich | 645990 | Ethyl 2-bromo-4-methylthiazole-5-carboxylate 97% | 22900-83-0 | 5g | $207 | 2023-01-07 | Buy |
| TCI Chemical | E0945 | Ethyl 2-Bromo-4-methylthiazole-5-carboxylate >97.0%(GC) | 22900-83-0 | 1g | $41 | 2026-04-30 | Buy |
| TCI Chemical | E0945 | Ethyl 2-Bromo-4-methylthiazole-5-carboxylate >97.0%(GC) | 22900-83-0 | 5g | $132 | 2024-03-01 | Buy |
| Biosynth | FE32887 | Ethyl 2-bromo-4-methylthiazole-5-carboxylate | 22900-83-0 | 50g | $150 | 2026-06-04 | Buy |
ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE Chemical Properties,Uses,Production
Chemical Properties
White powder
Uses
It finds its application in the preparation of thiazole-4- and -5-carboxylates, and an infrared study of their rotational isomers and in the discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects.
Synthesis
7210-76-6
22900-83-0
General procedure for the synthesis of ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate from ethyl 2-amino-4-methylthiazole-5-carboxylate: first, 2-methyl-1-nitro-propyl-propene (28.2 mL, 2.1 eq.) was dissolved in acetonitrile (700 mL) and the solution was cooled to 0 °C. Subsequently, bromo-trimethyl-silane (32 mL , 2.1 eq.). The reaction mixture was maintained at 0°C. Next, ethyl 2-amino-4-methyl-thiazole-5-carboxylate (18.6 g, 0.1 mol) was added to an acetonitrile/ethyl acetate (75/25) solution. After the dropwise addition was completed, the reaction mixture continued to be kept at 0°C. The mixture was warmed to room temperature and stirred for 24 hours. After completion of the reaction, the solvent was removed by evaporation and water was added. The product was extracted with ethyl acetate, the organic phase was dried with anhydrous sodium sulfate, filtered and concentrated. Finally, purification by fast chromatography using dichloromethane as eluent gave ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate as a yellow solid (21.74 g, 87 mmol, 87% yield); GC/MS analysis: [M+] C7H8BrNO2S 250.
References
[1] Patent: WO2004/6923, 2004, A1. Location in patent: Page/Page column 38
[2] Patent: WO2004/6924, 2004, A1. Location in patent: Page/Page column 31-32
[3] Patent: WO2004/7493, 2004, A1. Location in patent: Page 24-25
[4] Patent: EP2518054, 2012, A1. Location in patent: Page/Page column 53
[5] Patent: WO2008/47109, 2008, A1. Location in patent: Page/Page column 38
ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Shanghai zaiqi biology technology co., ltd | +86-21-54824098 13817598959 | sales@chemzq.com | CHINA | 136 | 58 |
| Hubei Ipure Biology Co., Ltd | +8618062405514 | ada@ipurechemical.com | China | 10236 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3461 | 58 |
View Lastest Price from ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-07-06 | ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE
22900-83-0
|
$1.00 | 1kg | 98% | 200kg | Career Henan Chemical Co |
-
- ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE
22900-83-0
- $1.00
- 98%
- Career Henan Chemical Co
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