2-Isopropyl-N,2,3-trimethylbutyramide
- CAS No.
- 51115-67-4
- Chemical Name:
- 2-Isopropyl-N,2,3-trimethylbutyramide
- Synonyms
- WS-23;2-ISOPROPYL-N,2,3-TRIMETHYLBUTYRAMIDE;2-Isopropyl-N,2,3-trimethylbutanamide;N,2,3-Trimethyl-2-propan-2-ylbutanamide;Trimethyl Isopropyl Butanamide;N,2,3-TRIMETHYL-2-ISOPROPYLBUTANAMIDE;FEMA 3804;N,2,3-Trimethyl-2-isopropylbutanamide,WS-23;3-trimethylbutyramide;methyldiisopropylpropionamide
- CBNumber:
- CB4227036
- Molecular Formula:
- C10H21NO
- Molecular Weight:
- 171.28
- MDL Number:
- MFCD00130070
- MOL File:
- 51115-67-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-Isopropyl-N,2,3-trimethylbutyramide >98.0%(GC) | I0729 | 5g | $23 |
| 2-Isopropyl-N,2,3-trimethylbutyramide >98.0%(GC) | I0729 | 25g | $59 |
| n,2,3-trimethyl-2-isopropylbutamide | BCA11567 | 100g | $206 |
| n,2,3-trimethyl-2-isopropylbutamide | BCA11567 | 250g | $345 |
| n,2,3-trimethyl-2-isopropylbutamide | BCA11567 | 500g | $620 |
| More product size | |||
| Melting point | 58-61 °C |
|---|---|
| Boiling point | bp0.35mm 83-85° |
| Density | 0.9419 (rough estimate) |
| vapor pressure | 0.3-0.32Pa at 25℃ |
| refractive index | 1.4621 (estimate) |
| FEMA | 3804 | 2-ISOPROPYL-N,2,3-TRIMETHYLBUTYRAMIDE |
| FLAVIS Number | 16.053 | 2-Isopropyl- N,2,3-trimethylbutanamide |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 16.46±0.46(Predicted) |
| form | Solid |
| color | White to Almost white |
| Odor | at 25.00 % in dipropylene glycol. mild cooling mentholic minty |
| Odor Type | minty |
| Merck | 14,9716 |
| JECFA Number | 1595 |
| Cosmetics Ingredients Functions | FRAGRANCE |
| InChI | 1S/C10H21NO/c1-7(2)10(5,8(3)4)9(12)11-6/h7-8H,1-6H3,(H,11,12) |
| InChIKey | RWAXQWRDVUOOGG-UHFFFAOYSA-N |
| SMILES | CNC(=O)C(C)(C(C)C)C(C)C |
| LogP | 2.5 at 25℃ and pH7 |
| CAS DataBase Reference | 51115-67-4(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | 2-ISOPROPYL-N,2,3-TRIMETHYLBUTYRAMIDE |
| FDA UNII | 6QOP5A9489 |
| EPA Substance Registry System | Butanamide, N,2,3-trimethyl-2-(1-methylethyl)- (51115-67-4) |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H302 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-52/53 | |||||||||
| Safety Statements | 37/39-26 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29242990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2-Isopropyl-N,2,3-trimethylbutyramide price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | I0729 | 2-Isopropyl-N,2,3-trimethylbutyramide >98.0%(GC) | 51115-67-4 | 5g | $23 | 2026-04-30 | Buy |
| TCI Chemical | I0729 | 2-Isopropyl-N,2,3-trimethylbutyramide >98.0%(GC) | 51115-67-4 | 25g | $59 | 2026-04-30 | Buy |
| Biosynth | BCA11567 | n,2,3-trimethyl-2-isopropylbutamide | 51115-67-4 | 100g | $206 | 2026-06-04 | Buy |
| Biosynth | BCA11567 | n,2,3-trimethyl-2-isopropylbutamide | 51115-67-4 | 250g | $345 | 2026-06-04 | Buy |
| Biosynth | BCA11567 | n,2,3-trimethyl-2-isopropylbutamide | 51115-67-4 | 500g | $620 | 2026-06-04 | Buy |
2-Isopropyl-N,2,3-trimethylbutyramide Chemical Properties,Uses,Production
Description
2-isopropyl-N,2,3-trimethylbutyramide is one nearly odorless white crystalline powder widely used as a coolant in medicinal preparations, oral care products, foodstuffs, cosmetics, and confection-eye products. It is an artificial synthesis cooling agent and could be synthesized by the Ritter reaction of 2,2-diisopropylpropionitrile (DIPPN) with methanol in the presence of acid. Compared with menthol, WS-23 is characterized by a continuous and long-lasting cooling and refreshing effect with no side effects of burning or stinging sensations. As an important additive in menthol cigarettes, WS-23 can cover up the bitter and astringent taste of cigarettes, make the cigarette feel fresh, improve the coordination and softness of cigarette smoke, and reduce the thorn in the mouth and throat. WS-23 is also compatible with other flavors and cooling agents[1].
Chemical Properties
2-Isopropyl-N-2,3-trimethylbutyramide has a cool, mint–menthol-type odor
Chemical Properties
N,2,3-Trimethyl-2-isopropylbutanamide is a white, crystalline powder,which gives a physiological
cooling sensation on skin or mucosa. It is mainly used to create cooling
and freshness in oral care preparations.
The material can be prepared by a Ritter reaction using N,2,3-trimethyl-2-
isopropylbutyronitrile as the starting material and alkylating agents such as, for
example, borates, carbonates, or phosphates.
Uses
Physiological coolant in foods, beverages, tobacco products, toiletries, cosmetics and pharmaceuticals.
Uses
2-Isopropyl-N,2,3-trimethylbutanamide is flavored compound and comprising the recount flavored compound for electronic cigarette liquid.
Definition
ChEBI: N,2,3-Trimethyl-2-(1-methylethyl)butanamide is a fatty amide.
Aroma threshold values
Aroma characteristics at 5.0%: slight cooling impact with little character.
Taste threshold values
Taste characteristics at 20 ppm: high-impacting cooling that lasts on the tongue and palate.
Trade name
Winsense WS-23 (Renessenz).
Synthesis
67029-99-6
51115-67-4
Step 3: 3-isopropyl-4-methyl-2-pentanone (128 g, 0.82 mol) obtained above was dissolved in tetrahydrofuran, followed by the addition of hydroxylamine hydrochloride (1.2 equiv.) and potassium carbonate and the reaction was stirred. The progress of the reaction was monitored by TLC and after confirming that the reaction was complete, water was added to the reaction mixture and extracted with ethyl acetate. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 135 g of crude product. The crude product was dissolved in polyphosphonic acid and heated to 100 °C for 3-8 hours. After the reaction was completed, the reaction solution was neutralized with alkali, extracted again with ethyl acetate, and the organic phase was dried over anhydrous sodium sulfate and then distilled under reduced pressure to remove the solvent. Finally, it was purified by recrystallization to obtain N,2,3-trimethyl-2-isopropylbutyramide 85 g with 99% purity and 49.7% combined yield.
References
[1] Ze-Hong Wu. “Acute and subacute inhalation toxicity assessment of WS-23 in Sprague-Dawley rats.” Journal of Applied Toxicology (2021): 1826–1838.
2-Isopropyl-N,2,3-trimethylbutyramide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai 3S Technology Co., Ltd | +86-18221206281 +86-18221206281 | luqing@3s-tech.net | China | 59 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
| COSMAN CHEMICAL CO., LTD. | +8613761622051 | sales@cosmanchem.com | China | 14 | 58 |
| Hebei Fengmu Trading Co., Ltd. | +8613393234347 | Lyla@fengmuchem.com | China | 2943 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +8617392709771 | 1097@dideu.com | China | 3992 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5228 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Taixing Foreign Trade Nanjing Co., Ltd. | +86-025-83346564; +8613182976929 | sales@tx-chem.com | China | 125 | 58 |
Related articles
- 2-Isopropyl-N,2,3-trimethylbutyramide: Synthesis, Toxicity and Risk Assessment
- 2-isopropyl-N,2,3-trimethylbutyramide is a well-known artificial synthesis cooling agent widely used in foods, medicines, and ....
- Mar 19，2025
View Lastest Price from 2-Isopropyl-N,2,3-trimethylbutyramide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-28 | Cooling Agent Ws-23
51115-67-4
|
$1.00 | 10kg | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-05-20 | N,2,3-Trimethyl-2-isopropylbutamide
51115-67-4
|
99% | 20tons | Chongqing Zhihe Biopharmaceutical Co., Ltd. | |||
|
|
2026-05-20 | WS-23,N,2,3-Trimethyl-2-isopropylbutamide
51115-67-4
|
99% | 20tons | Chongqing Zhihe Biopharmaceutical Co., Ltd. |
-
- Cooling Agent Ws-23
51115-67-4
- $1.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- N,2,3-Trimethyl-2-isopropylbutamide
51115-67-4
- 99%
- Chongqing Zhihe Biopharmaceutical Co., Ltd.
-
- WS-23,N,2,3-Trimethyl-2-isopropylbutamide
51115-67-4
- 99%
- Chongqing Zhihe Biopharmaceutical Co., Ltd.
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