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BIS-Tris

BIS-Tris structure

CAS No.: 6976-37-0

Chemical Name:: BIS-Tris

Synonyms: BIS-TRIS;2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol;BIS(2-HYDROXYETHYL)IMINOTRIS(HYDROXYMETHYL)METHANE;BIS(2-HYDROXYETHYL)AMINO-TRIS(HYDROXYMETHYL)METHANE;BIS-TRIS BUFFER;BIS-HYDROXYETHYL TROMETHAMINE;Bis-Iris;2,2-BIS(HY;''BIS-TRIS'';BIS-TRIS >99%

CBNumber:: CB4304881

Molecular Formula:: C8H19NO5

Molecular Weight:: 209.24

MDL Number:: MFCD00002853

MOL File:: 6976-37-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:32:54

Product description	Number	Pack Size	Price
BIS-TRIS	RES1161B-A7	100g	$348
BIS-TRIS	RES1161B-A7	25kg	$15860
BIS-TRIS	PHG0004	1KIT	$1190
BIS-TRIS BioPerformance Certified, cell culture tested, suitable for insect cell culture, ≥98.0%	B4429	1kg	$1390
BIS-TRIS BioUltra, ≥99.0% (NT)	14879	100g	$275
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BIS-Tris Properties

Melting point	104 °C(lit.)
Boiling point	466.2±40.0 °C(Predicted)
Density	1.346±0.06 g/cm3(Predicted)
vapor pressure	0Pa at 25℃
storage temp.	Inert atmosphere,Room Temperature
solubility	H₂O: 1 M at 20 °C, clear, colorless
form	Solution
color	Yellow to orange
Odor	Odorless
PH Range	5.8 - 7.2
PH	9.0-10.1 (20-25℃, 1M in water)
pka	6.5(at 25℃)
biological source	synthetic
Water Solubility	soluble
Sensitive	Air Sensitive
λmax	λ: 280 nm Amax: 0.15
BRN	2205275
Major Application	diagnostic assay manufacturing
Cosmetics Ingredients Functions	BUFFERING
InChI	1S/C8H19NO5/c10-3-1-9(2-4-11)8(5-12,6-13)7-14/h10-14H,1-7H2
InChIKey	OWMVSZAMULFTJU-UHFFFAOYSA-N
SMILES	OCCN(CCO)C(CO)(CO)CO
LogP	-2.26 at 20℃
CAS DataBase Reference	6976-37-0(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	Q1XC3631CP
EPA Substance Registry System	1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)- (6976-37-0)
Absorption	cut-off at 270nm in H2O at 1M
UNSPSC Code	12352200
NACRES	NA.25

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H318

Precautionary statements

P280-P305+P351+P338+P310

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-21/22-20/21/22

Safety Statements

26-36-36/37/39-22

WGK Germany

10-23

TSCA

TSCA listed

HS Code

29221980

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2

REACH Registrations

Active

NFPA 704

	1
2		0

BIS-Tris price More Price(150)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	RES1161B-A7	BIS-TRIS	6976-37-0	100g	$348	2026-04-30	Buy
Sigma-Aldrich	RES1161B-A7	BIS-TRIS	6976-37-0	25kg	$15860	2026-04-30	Buy
Sigma-Aldrich	PHG0004	BIS-TRIS	6976-37-0	1KIT	$1190	2026-04-30	Buy
Sigma-Aldrich	B4429	BIS-TRIS BioPerformance Certified, cell culture tested, suitable for insect cell culture, ≥98.0%	6976-37-0	1kg	$1390	2026-04-30	Buy
Sigma-Aldrich	14879	BIS-TRIS BioUltra, ≥99.0% (NT)	6976-37-0	100g	$275	2026-04-30	Buy

Product number	Packaging	Price	Buy
RES1161B-A7	100g	$348	Buy
RES1161B-A7	25kg	$15860	Buy
PHG0004	1KIT	$1190	Buy
B4429	1kg	$1390	Buy
14879	100g	$275	Buy

BIS-Tris Chemical Properties,Uses,Production

Chemical Properties

White/clear crystalline powder

Uses

Bis Tris is a commonly used biological buffer for very broad usage in biological systems such as diagnostics, electrophoresis and protein based bioprocessing. The pKa of Bis Tris is 6.36 which makes it a good candidate for biological-based formulations.

Bis Tris is used in a wide variety of biological applications including protein separation buffers, cell culture media, electrophoresis separations and diagnostic reagent formulations.

Uses

It is used as a biological buffer, organic synthesize, chemical & pharmaceutical intermediate. It is suitable for fractionation of hemoglobin.

Uses

Bis-Tris, also known as bis-Tris methane, is a zwitterionic buffering agent used in biochemistry and molecular biology. It is a bis(2-hydroxyethyl)amine and Tris family buffer. Bis Tris is a common component of many buffer systems for various types of electrophoresis. Bis-Tris may form a complex with some common metals, such as Cu(II) and Pb(II), and formation constants should be taken into account when using this buffer in a solution containing metal ions. Bis-Tris can be used as a substitute for the highly toxic buffer cacodylate.

Definition

ChEBI: Bis-tris is a buffer substance useful for calibration of glass electrodes and for the preparation of the biochemical and biological buffer solutions; pKa = 6.46 at 25 ℃. It has a role as a buffer. It is functionally related to a member of tris.

Flammability and Explosibility

Not classified

Purification Methods

Crystallise BIS-TRIS from hot 1-butanol and dry it in a vacuum at 25o. N,N-Bis-(2-hydroxyethyl)glycine (BICINE) See in “Amino Acids and Peptides”, Chapter 6.

BIS-Tris Preparation Products And Raw materials

Raw materials

Preparation Products

BIS-Tris Suppliers

Global( 599)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jiangsu Magic Biotechnology Co., Ltd	+undefined13921770081	SVP01@magicbiotech.cn	China	92	58
Suzhou Genemill Biotechnology Co.,Ltd	+86-0512-65917170 +86-15862502491	glm@genemill.com	China	39	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Qingdao Gangliwei Import & EXport Co.,Ltd	+8613668859477	linda@gliverchem.com	China	61	58
Watson Biotechnology Co.,Ltd	+86-18186686046 +86-18186686046;	sales01@watsonbiotech.cn	China	5733	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33324	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850	info@fortunachem.com	China	5983	58

Supplier	Advantage
Jiangsu Magic Biotechnology Co., Ltd	58
Suzhou Genemill Biotechnology Co.,Ltd	58
Aladdin Scientific	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Qingdao Gangliwei Import & EXport Co.,Ltd	58
Watson Biotechnology Co.,Ltd	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Hebei Yanxi Chemical Co., Ltd.	58
Wuhan Fortuna Chemical Co., Ltd	58

Bis-Tris Methane: Zwitterionic Buffer & Protein Separation Optimization
Bis-Tris (zwitterionic buffer) works at pH 5.8-7.2, optimizes SDS-PAGE/Western blot with sharp bands, and substitutes toxic ca....
Dec 17，2025

View Lastest Price from BIS-Tris manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-08	BIS-TRIS 6976-37-0		1kg	99%	20MT	Watson Biotechnology Co.,Ltd
2026-06-08	BIS-TRIS 6976-37-0		1kg	99%-101%	500 KG	WUHAN FORTUNA CHEMICAL CO., LTD
2026-05-28	2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol 6976-37-0	$2.00-5.00	1KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD

BIS-TRIS
6976-37-0
99%
Watson Biotechnology Co.,Ltd

BIS-TRIS
6976-37-0
99%-101%
WUHAN FORTUNA CHEMICAL CO., LTD

2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol
6976-37-0
$2.00-5.00
99%
Hebei Chuanghai Biotechnology Co,.LTD

BIS-Tris Spectrum

BIS-Tris(6976-37-0)MS BIS-Tris(6976-37-0)¹HNMR BIS-Tris(6976-37-0)IR1 BIS-Tris(6976-37-0)IR2 BIS-Tris(6976-37-0)Raman

6976-37-0(BIS-Tris)Related Search:

2-(METHYLSULFONYL)ETHANOL Hydroxyethyl starch Tricine Tris(hydroxymethyl)nitromethane Hydroxyethyl Cellulose

Methyl 2-hydroxyethyl cellulose 2-(2-Aminoethylamino)ethanol BUFFER SOLUTION PH = 6,00 (20 °C) (POTASSIUM DIHYDROGEN PHOSPHATE/SODIUM HYDROXIDE) 4,4'-Methylenedianiline Sodium isethionate

Tris(hydroxymethyl)aminomethane 2-(ISOPROPYLAMINO)ETHANOL tert-Butylamine Diethanolamine Triethylamine

2-Amino-1,3-propanediol BIS-TRIS-D19 Hydroxymethyl

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2,2-BIS(HYDROXYETHYL)-(IMINOTRIS)-(HYDROXYMETHYL)-METHANE 2-BIS[2-HYDROXYETHYL]AMINO-2-[HYDROXYMETHYL]1,3-PROPANEDIOL 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-3-propanediol Bis Tris Bis(2-hydroxyethyl)imino-tris(hydroxymethyl)methane Bis Tris, Molecular Biology Grade Bis(2-hydroxyethyl)imino-tris(hydroxymethyl)methane, Molecular Biology Grade Bis(2-hydroxyethyl)aminotris(hydroxymethyl)methane~Bis-TRIS Bis-Tris (2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol) BIS-TRIS BIOULTRA, >= 99.0% (NT) BIS-TRIS, BIOPERFORMANCE CERTIFIED& 2,2-Bis(hydroxymethyl)-2,2′,2″-nitrilotriethanol 2-Bis(2-hydroxyethyl)amino-2-(hydroxymethyl)-1,3-propanediol Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane Bis-tris BIS-Tris, ULTROL Bis-Tris, Cell culture reagent BIS(2-HYDROXYETHYL)IMINO-TRIS(HYDROXYMETHYL)PROPANE BIS(HYDROXYETHYL)IMINO-TRIS-(HYDROXYMETHYL)-METHANE ''BIS-TRIS'' 2,2-BIS(HYDROXYMETHYL)-2,2',2''-NITRILOETHANOL 2,2-BIS-(HYDROXYMETHYL)-2,2',2'-NITRILOTRIETHANOL 2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol, 99+% 2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol, for biochemistry, 99+% Bis[(2-hydroxyethyl)amino]-2-(hydroxymethyl)- 1,3-propanediol 1,3-Propanediol, 2-bis(2-hydroxyethyl)amino-2-(hydroxymethyl)- Bis(2-hydroxyethyl)iminotris(hydroxylmethyl)methane Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)propane BIS(2-HYDROXYETHYL)-TRIS(HYDROXYMETHYL)METHANE BIS-TRIS (BIS(2-HYDROXYETHYL)AMINO-TRIS(HYDROXYMETHYL)METHANE) BIS(2-HYDROXYETHYL)IMINOTRIS(HYDROXYMETHYL)METHANE(BIS-TRIS) Bis(2-hydroxyethyl)aminotris(hydroxymethyl)methane >98% bis-tris cell culture tested bis-tris free base bis-tris free base sigmaultra BIS-Tris, ULTROL Grade 2,2-BIS(HYDROXYMETHYL)-2,2',2''-NITRILO- TRIETHANOL, 98+% BIS-TRIS, BIOTECHNOLOGY PERFORMANCE CERT IFIED BIS(2-HYDROXYETHYL)AMINO-TRIS(HYDROXYMET L)-METHAN BIS(2-HYDROXYETHYL)IMINO-TRIS(HYDROXYMETHYL)PROPANE （BIS-TRIS） (2-Hydroxyethyl)iMinotris(hydroxyMethyl)Methane(BIS-TRIS) 2-[bis(2-hydroxyethyl)aMino]-3-(hydroxyMethyl)pentane-1,5-diol Bis(2-hydroxyethyl)aMinotris(hydroxyMethyl)Methane Bis(2-hydroxyethyl)iMinotris(hydroxyMethyl)Methan 2,2-Bis(hydroxyMethyl)-2,2',2''-nitrilotriethanol (BIS-TRIS) BIS-TRIS >99% BIS-TRIS Vetec(TM) reagent grade, >=98%, RNase and DNase free COLOREX CLOSTRIDIUM DIFFICILE 90MM INDICATOR PAPER ROTA PH 1-10 ROLL ROSE BENGAL CHLOR.PENASE 90MM DOUBLE-WR. 2,2-Bis(hydroxymethyl)-2,2μ,2-nitrilotriethanol, 2-Bis(2-hydroxyethyl)amino-2-(hydroxymethyl)-1,3-propanediol, Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane 2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol, 99+%, for biochemistry 2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol, for biochemistry 2,2'-[2-Hydroxy-1,1-bis(hydroxymethyl)ethylimino]bisethanol 2,2-Bis(hydroxymethyl)-(2,2',2''-nitrilotrisethanol) 2,2-BIS(HY 2-[Bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)- BIS-TRIS,2,2-Bis(hydroxymethyl)-2,2′,2″-nitrilotriethanol, 2-Bis(2-hydroxyethyl)amino-2-(hydroxymethyl)-1,3-propanediol, Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane BIS-TRIS >98% 2-[Bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propan-1,3-diol China Factory supply BIS-TRIS CAS 6976-37-0 2,2-Bis(Hydroxyme BIS-TRIS Molecular Biology

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BIS-Tris

BIS-Tris Properties

SAFETY

Risk and Safety Statements

BIS-Tris price More Price(150)

BIS-Tris Chemical Properties,Uses,Production

Chemical Properties

Uses

Uses

Uses

Definition

Flammability and Explosibility

Purification Methods

BIS-Tris Preparation Products And Raw materials

Raw materials

Preparation Products

BIS-Tris Suppliers

Related articles

View Lastest Price from BIS-Tris manufacturers

BIS-Tris Spectrum

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