(-)-LUPININE
- CAS No.
- 486-70-4
- Chemical Name:
- (-)-LUPININE
- Synonyms
- LUPININE;LUPININ;(-)-LUPININE;(–)-Lupinine;(-)-Lupinine;LUPININE HCL(P);(-)-Lupinine,97%;Lupinine, 10 mM in DMSO;OCTAHYDRO-1H-QUINOLIZIN-1-METHANOL;[(1R,9aR)-quinolizidin-1-yl]methanol
- CBNumber:
- CB4409360
- Molecular Formula:
- C10H19NO
- Molecular Weight:
- 169.26
- MDL Number:
- MFCD00213431
- MOL File:
- 486-70-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| (-)-Lupinine phyproof® Reference Substance | PHL86294 | 25 mg | $302 |
| (-)-Lupinine | FL61612 | 0.05g | $240.2 |
| (-)-Lupinine | FL61612 | 0.1g | $384.33 |
| (-)-Lupinine | FL61612 | 0.25g | $625.67 |
| (-)-Lupinine | FL61612 | 0.5g | $960.82 |
| More product size | |||
| Melting point | 62-65°C |
|---|---|
| alpha | D26 -25.9° (c = 3 in water); D28 -21° (c = 9.5 in alcohol) |
| Boiling point | 160-164°C 4mm |
| Density | 0.9660 (rough estimate) |
| refractive index | 1.4610 (estimate) |
| Flash point | 160-164°C/4mm |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly) |
| form | Very Dark Orange |
| pka | 14.90±0.10(Predicted) |
| color | Light yellow to yellow |
| Merck | 14,5609 |
| BRN | 80447 |
| Stability | Hygroscopic |
| LogP | 1.290 (est) |
| CAS DataBase Reference | 486-70-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 33BAJ73U1F |
| NIST Chemistry Reference | 2H-quinolizine-1-methanol, octahydro-, (1r-trans)-(486-70-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H332 | |||||||||
| Precautionary statements | P261-P280h-P301+P312a-P304+P340-P321-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 20/21/22-41 | |||||||||
| Safety Statements | 22-36/37-39-26 | |||||||||
| RIDADR | 1544 | |||||||||
| RTECS | OK5802000 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| NFPA 704 |
|
(-)-LUPININE price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL86294 | (-)-Lupinine phyproof® Reference Substance | 486-70-4 | 25 mg | $302 | 2026-04-30 | Buy |
| Biosynth | FL61612 | (-)-Lupinine | 486-70-4 | 0.05g | $240.2 | 2026-06-04 | Buy |
| Biosynth | FL61612 | (-)-Lupinine | 486-70-4 | 0.1g | $384.33 | 2026-06-04 | Buy |
| Biosynth | FL61612 | (-)-Lupinine | 486-70-4 | 0.25g | $625.67 | 2026-06-04 | Buy |
| Biosynth | FL61612 | (-)-Lupinine | 486-70-4 | 0.5g | $960.82 | 2026-06-04 | Buy |
(-)-LUPININE Chemical Properties,Uses,Production
Description
This lupin alkaloid was first obtained by Baumert and is present in numerous
plants of the Lupinus family, the most important sources being L. luteus, L.
niger and L. palmeri Wats. It crystallizes from light petroleum in colourless
rhombs and may be boiled without decomposition in a stream of hydrogen. It is
laevorotatory with [α]17D - 20.35° (EtOH) and is soluble in H20 and most
organic solvents but only sparingly so in petroleum ether. It is a sufficiently
strong base to liberate ammonia from its salts. The hydrochloride forms colourless rhombic crystals from aqueous EtOH, m.p. 2l2-3°C; [α]D - 14° (H20);
the hydriodide has m.p. 140-1 DC; aurichloride, m.p. 211-3°C; platinichloride
as yellow crystals, m.p. 166-166.5°C; (+)-tartrate, m.p. 171°C; [α]D + 15.5°
(EtOH); methochloride, m.p. 212-3°C; methiodide, m.p. 295-6°C; phenylurethane, m.p. 98-9°C; (-)-camphorsulphonate, m.p. 184°C; [α]D - 15.3° and the
(+)-camphorsulphonate, m.p. 182-3°C; [α]D + 22.5°. The formation of a
benzoyl derivative, m.p. 49-S00 C, oxidation of the alkaloid to lupininic acid,
C9H16.COOH, m.p. 255°C and dehydration to anhydrolupinine, ClOH17N, a
colourless oil of unpleasant odour, b.p. 216-7°C/726 mm all show the presence
of a primary alcoholic hydroxyl group. Lupinine does not contain a methylimino
group and behaves as a tertiary base. On exhaustive methylation it gives, in three
stages, trimethylamine and an unsaturated alcohol. From this, it may be deduced
that the alkaloid contains a bicyc1ic system. Several unsuccessful attempts were made to synthesize the alkaloid before this was finally achieved by Clemo and
his co-workers.
This alkaloid, like the others of the lupinane group, is of little importance in
medicine although the p-aminobenzoate has been shown to possess a marked
local anaesthetic action.
The (+ )-form of the alkaloid has m.p. 68°C; [α]D + 19.9° and yields the (-)-
tartrate, m.p.167-8°C; [α]D -15.8°.
Chemical Properties
Crystalline solid, obtained as orthorhombic prisms from acetone; melts at 69°C(156.2°F); bp 270°C (518°F); strongly basic;soluble in water and organic solvents.
Uses
The ι-form of lupinine occurs in seeds andherb of Lupinus luteous L., Chenopodiaceae,and other lupinus species. Its clinical applications are very limited.
Uses
antifeedant, antiinflammatory, oxytoxic
Uses
(-)-Lupinine is an alkaloid capable of counteracting ethanol anesthesia.
Definition
ChEBI: Lupinine is a quinolizidine alkaloid.
Health Hazard
This alkaloid is moderately toxic. The toxicaction, however, is lower than that of cytisine. Ingestion of high doses may producenausea, convulsions, and respiratory fail ure. The lethal dose in guinea pigs by theintraperitoneal route is 28 mg/kg..
References
Baumert., Ber., 14, 1150, 1321, 1880, 1882 (1881)
Baumert., ibid, 15,631,1951 (1882)
Schmidt, Berend., Arch. Pharm., 235,263 (1897)
Willstiitter, Fourneau., Ber., 35, 1914 (1902)
Karrer et al., Helv. Chirn. Acta, 11, 1062 (1928)
Clemo, Raper, J. Chern. Soc., 1927 (1929)
Winterfeldt, Cosel., Arch. Pharrn., 70, 278 (1940)
Sadykov, Spasokukotski., J. Gen. Chern. USSR, 13,830 (1943)
Sadykov., ibid, 19,143 (1949)
Zaboev., ibid, 18,194 (1948)
Ratusky, Sorm., Chern. Listy., 47, 1491 (1953)
(-)-LUPININE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-86-17392712697 +8617792793228 | 1069@dideu.com | China | 8609 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19956 | 58 |
View Lastest Price from (-)-LUPININE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-14 | Lupinine
486-70-4
|
$31.00-86.00 | 99.95% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-14 | Lupinine
486-70-4
|
$31.00-86.00 | 99.95% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-05-01 | Lupinine
486-70-4
|
$31.00-86.00 | 99.95% | 10g | TargetMol Chemicals Inc. |
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