ChemicalBook >> CAS DataBase List >>6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
- CAS No.
- 164148-92-9
- Chemical Name:
- 6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
- Synonyms
- TERT-BUTYL 6-AMINO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE;164148-92-9;6-AMINO-2-BOC-3,4-DIHYDRO-1H-ISOQUINOLINE;2-Boc-6-amino-1,2,3,4-tetrahydroisoquinoline;6-Amino-2-Boc-1,2,3,4-tetrahydro-isoquinoline;6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE;6-Amino-2-N-Boc-1,2,3,4-tetrahydroisoquinoline, >=98%;REF DUPL: 6-Amino-2-N-Boc-1,2,3,4-tetrahydro-isoquinoline;TERT-BUTYL 6-AMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLATE;tert-butyl 6-amino-1,2,3,4-tetrahydroisoquinoline-2-carboxylate
- CBNumber:
- CB4419398
- Molecular Formula:
- C14H20N2O2
- Molecular Weight:
- 248.32
- MDL Number:
- MFCD03426351
- MOL File:
- 164148-92-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-28 02:49:16
| Product description | Number | Pack Size | Price |
| 6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE 95% | 56015 | 1G | $33 |
| 6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE 95% | 56015 | 5G | $85 |
| 6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE 95% | 56015 | 25G | $469 |
| 6-Amino-2-N-BOC-1,2,3,4-tetrahydro-isoquinoline 98% | OR313033 | 100mg | $21 |
| 6-Amino-2-N-BOC-1,2,3,4-tetrahydro-isoquinoline 98% | OR313033 | 250mg | $28 |
| More product size | |||
| Boiling point | 394.7±42.0 °C(Predicted) |
|---|---|
| Density | 1.145±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| pka | 4.35±0.20(Predicted) |
| Appearance | Off-white to yellow Solid |
| InChI | InChI=1S/C14H20N2O2/c1-14(2,3)18-13(17)16-7-6-10-8-12(15)5-4-11(10)9-16/h4-5,8H,6-7,9,15H2,1-3H3 |
| InChIKey | OLOIFCYZWOTWRO-UHFFFAOYSA-N |
| SMILES | C1C2=C(C=C(N)C=C2)CCN1C(OC(C)(C)C)=O |
| CAS DataBase Reference | 164148-92-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Hazard Codes | Xn,N |
| Risk Statements | 36/37/38-50-22 |
| Safety Statements | 26-36/37/39-61 |
| RIDADR | UN2811 |
| HS Code | 2922390090 |
6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE price More Price(79)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 56015 | 6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE 95% | 164148-92-9 | 1G | $33 | 2026-04-30 | Buy |
| AstaTech | 56015 | 6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE 95% | 164148-92-9 | 5G | $85 | 2026-04-30 | Buy |
| AstaTech | 56015 | 6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE 95% | 164148-92-9 | 25G | $469 | 2026-04-30 | Buy |
| Apolloscientific | OR313033 | 6-Amino-2-N-BOC-1,2,3,4-tetrahydro-isoquinoline 98% | 164148-92-9 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR313033 | 6-Amino-2-N-BOC-1,2,3,4-tetrahydro-isoquinoline 98% | 164148-92-9 | 250mg | $28 | 2026-06-04 | Buy |
6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE Chemical Properties,Uses,Production
Uses
6-Amino-2-N-Boc-1,2,3,4-tetrahydroisoquinoline is used as a reagent in the preparation of potent and long acting oral factor Xa inhibitors.
Synthesis
![2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-6-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester](/CAS/20210305/GIF/1154424-63-1.gif)
1154424-63-1
164148-92-9
General procedure for the synthesis of 6-amino-2-N-BOC-1,2,3,4-tetrahydro-isoquinoline from compound (CAS:1154424-63-1): ammonium formate (3.68 g, 57.5 mmol) was added to a stirred ethanol (EtOH, 25 mL) solution of compound 2 (2.2 g, 5.75 mmol) and the reaction mixture was heated to refluxed for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature and filtered through a diatomaceous earth bed to remove insoluble impurities. Subsequently, the diatomaceous earth bed and the filtrate were combined and concentrated under reduced pressure to afford compound 3 (1.3 g, 91% yield) as a dark brown oil, which could be used in subsequent reactions without further purification.
References
[1] Patent: WO2009/158571, 2009, A1. Location in patent: Page/Page column 165; 167; 168
6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE Preparation Products And Raw materials
Global( 154)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 722 | 55 | |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
View Lastest Price from 6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
164148-92-9
|
$8.00 | 1KG | 99% | 10tons | Career Henan Chemical Co |
-
- 6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
164148-92-9
- $8.00
- 99%
- Career Henan Chemical Co
164148-92-9(6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE)Related Search:
6-AMINO-2-BOC-3,4-DIHYDRO-1H-ISOQUINOLINE
6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
6-AMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
2-Boc-6-amino-1,2,3,4-tetrahydroisoquinoline
REF DUPL: 6-Amino-2-N-Boc-1,2,3,4-tetrahydro-isoquinoline
2(1H)-Isoquinolinecarboxylic acid, 6-amino-3,4-dihydro-, 1,1-dimethylethyl ester
tert-butyl6-amino-1,4,4a,8a-tetrahydroisoquinoline-2(3H)-carboxylate
6-Amino-2-N-Boc-1,2,3,4-tetrahydroisoquinoline, >=98%
tert-butyl 6-amino-1,2,3,4-tetrahydroisoquinoline-2-carboxylate
6-Amino-2-Boc-1,2,3,4-tetrahydro-isoquinoline
TERT-BUTYL 6-AMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLATE
164148-92-9
6-Amino-3,4-dihydro-1H-isoquinolin-2-carboxylic acid tert-butyl ester
6-Amino-3,4-dihydro-2(1H)-isoquinolinecarboxylic acid tert-butyl ester
TERT-BUTYL 6-AMINO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
164148-92-9
pharmacetical
