Pheophorbide A
- CAS No.
- 15664-29-6
- Chemical Name:
- Pheophorbide A
- Synonyms
- PHEOPHORBIDE A;Phaeophorbide A;Pheophorbide A (>13-Epi-phaeophorbide-a;Chlorophyll Impurity 2;pheophorbide a AldrichCPR;Demagnesia chloric acid -a;PHEOPHORBIDE A (In Solution);Pheophorbide a (mixture of diastereomers);[3s-(3alpha,4beta,21beta)]-ramethyl-20-oxo
- CBNumber:
- CB4426628
- Molecular Formula:
- C35H36N4O5
- Molecular Weight:
- 592.7
- MDL Number:
- MFCD00210345
- MOL File:
- 15664-29-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Pheophorbide-a ≥90% (HPLC) | SML1218 | 10MG | $52.3 |
| Pheophorbide a ≥90%(mixtureofdiastereomers) | 16072 | 25mg | $75 |
| Pheophorbide a ≥90%(mixtureofdiastereomers) | 16072 | 50mg | $143 |
| Pheophorbide a ≥90%(mixtureofdiastereomers) | 16072 | 100mg | $266 |
| Pheophorbide a ≥90% (mixture of diastereomers) | 16072 | 25mg | $68 |
| More product size | |||
| Melting point | 191-195 °C |
|---|---|
| Boiling point | 1019.0±65.0 °C(Predicted) |
| Density | 1.282±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO: soluble0.5mg/mL, clear (warmed) |
| form | Solid |
| color | blue, to dark brown to black |
| Stability | Light Sensitive |
| InChIKey | NSFSLUUZQIAOOX-QEWKCGBTSA-N |
| SMILES | O=C([C@@H]1C(OC)=O)C(C(N/2)=C1C([C@@H](CCC(O)=O)[C@@H]/3C)=NC3=C/4)=C(C)C2=C\C5=N/C(C(C)=C5CC)=C\C6=C(C=C)C(C)=C4N6 |
| FDA UNII | IA2WNI2HO2 |
| EPA Substance Registry System | 3-Phorbinepropanoic acid, 9-ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-, (3S,4S,21R)- (15664-29-6) |
| UNSPSC Code | 12161501 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Pheophorbide A price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1218 | Pheophorbide-a ≥90% (HPLC) | 15664-29-6 | 10MG | $52.3 | 2026-04-30 | Buy |
| Cayman Chemical | 16072 | Pheophorbide a ≥90%(mixtureofdiastereomers) | 15664-29-6 | 25mg | $75 | 2026-04-30 | Buy |
| Cayman Chemical | 16072 | Pheophorbide a ≥90%(mixtureofdiastereomers) | 15664-29-6 | 50mg | $143 | 2026-04-30 | Buy |
| Cayman Chemical | 16072 | Pheophorbide a ≥90%(mixtureofdiastereomers) | 15664-29-6 | 100mg | $266 | 2026-04-30 | Buy |
| Cayman Chemical | 16072 | Pheophorbide a ≥90% (mixture of diastereomers) | 15664-29-6 | 25mg | $68 | 2024-03-01 | Buy |
Pheophorbide A Chemical Properties,Uses,Production
Uses
Pheophorbide a is a chlorophyll-related compound studied for it’s anti-tumor & anti-cancer activity.
Uses
Pheophorbide-a has been used as a photosensitizer:
- for the photodynamic therapy (PDT) in oral cancer cell lines
- to test its effect on inducing oxidative stress and death in L. amazonensis
- to test its effect on the viability of HeLa cells
Definition
ChEBI: Pheophorbide a is a pheophorbide. It is a conjugate acid of a pheophorbide a(2-).
Biochem/physiol Actions
Pheophorbide-a, due to its photosensitizing effect, may serve as a promising bioactive compound to treat leishmaniasis. It is a metabolite of chlorophyll and possesses immunostimulation functionality. Pheophorbide-a is a photosensitizer for the photodynamic therapy. It is an ATP Binding Cassette Subfamily G Member 2 (ABCG2) transporter specific substrate. Overexpression of ATP-binding cassette (ABC) transporters in cancer cells is associated with the multidrug resistance phenotype.
in vivo
Pheophorbide A-mediated photodynamic therapy (Pa-PDT) (10 mg/kg (i.v.) or 30 mg/kg (i.p.)) significantly inhibits tumor growth in C3H mouse model with subcutaneous injection of AT-84 cells[3].
| Animal Model: | Male immunocompetent C3H mouse (six-week-old, inoculated subcutaneously with AT-84 cells)[3] |
| Dosage: | 10 mg/kg intravenous (i.v.) or a 30 mg/kg intraperitoneal (i.p.) injection |
| Administration: | IV or IP; after 24 h, PDT was performed |
| Result: | Pa-PDT, especially i.v. Pa-PDT, significantly inhibited tumor growth up to 70%, while the i.p. Pa-PDT-induced inhibition was up to 43.4% relative to the control group at the end of period. |
Enzyme inhibitor
This chlorophyll a degradation intermediate (MW = 579.68 g/mol; CAS 15664-29-6), which is identical to chlorophyll a, except for the absence of the latter’s magnesium ion and ester at the 17-position, is obtained by acid hydrolysis of chlorophyll a. Pheophorbide a inhibits acyl-CoA:cholesterol acyltransferase and magnesium protoporphyrin IX methyltransferase, acts as an endothelin receptor antagonist, and also induces apoptosis. Pheophorbide a is also as an anti-tumor promoter.
Pheophorbide A Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| RongNa Biotechnology Co.,Ltd | +86-86-13583358881 +8618560316533 | Brad@rongnabiotech.com | China | 3364 | 58 |
| Hebei Longbang Technology Co., LTD | +86-18633929156 | admin@hblongbang.com | China | 972 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21586 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Chengdu Aslee Biopharmaceuticals, Inc. | 28-85305008 | CHINA | 964 | 58 | |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9546 | 58 |
| Aktin Chemicals, Inc. | 028-85159085 | info@aktinchem.com | CHINA | 1025 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
View Lastest Price from Pheophorbide A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-11 | Pheophorbide A
15664-29-6
|
$10.00 | 1ASSAYS | 99% | 1 ton | RongNa Biotechnology Co.,Ltd | |
 |
2026-06-01 | Pheophorbide a
15664-29-6
|
$62.00-198.00 | 99.99% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-03-28 | Pheophorbide A
15664-29-6
|
$6.00 | 1KG | 99% | 20TONS | Hebei Longbang Technology Co., Ltd |
-
- Pheophorbide A
15664-29-6
- $10.00
- 99%
- RongNa Biotechnology Co.,Ltd
-
- Pheophorbide a
15664-29-6
- $62.00-198.00
- 99.99%
- TargetMol Chemicals Inc.
-
- Pheophorbide A
15664-29-6
- $6.00
- 99%
- Hebei Longbang Technology Co., Ltd
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