1-Hexadecanol
- CAS No.
- 36653-82-4
- Chemical Name:
- 1-Hexadecanol
- Synonyms
- CETYL ALCOHOL;HEXADECANOL;HEXADECAN-1-OL;FEMA 2554;Ethol;FEMA 3554;Lanette 16;CETANOL;Cetylic alcohol;Lipocol C
- CBNumber:
- CB4853561
- Molecular Formula:
- C16H34O
- Molecular Weight:
- 242.44
- MDL Number:
- MFCD00004760
- MOL File:
- 36653-82-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1-Hexadecanol ≥99% | W255408 | 1 each | $58 |
| Cetyl alcohol for synthesis | 8.18704 | 100g | $32.1 |
| Cetyl alcohol European Pharmacopoeia (EP) Reference Standard | C0990000 | 300 mg | $254 |
| Cetyl alcohol for synthesis | 8.18704 | 1kg | $77.6 |
| Cetyl alcohol analytical standard | 68824 | 1g | $38.7 |
| More product size | |||
| Melting point | 48-50 °C (lit.) |
|---|---|
| Boiling point | 179-181 °C/10 mmHg (lit.) |
| Density | 0.818 g/mL at 25 °C (lit.) |
| bulk density | 410-450kg/m3 |
| vapor density | 8.34 (vs air) |
| vapor pressure | <0.01 mm Hg ( 43 °C) |
| FEMA | 2554 | 1-HEXADECANOL |
| refractive index | nD79 1.4283 |
| FLAVIS Number | 02.009 | Hexadecan-1-ol |
| Flash point | 275 °F |
| storage temp. | Store below +30°C. |
| solubility | Soluble in alcohol, chloroform, ether |
| form | Powder, Flakes or Pellets |
| pka | 15.20±0.10(Predicted) |
| color | White to off-white |
| Odor | at 100.00 %. waxy clean greasy floral oily |
| Odor Type | waxy |
| biological source | synthetic |
| Viscosity | 3.394mm2/s |
| explosive limit | 8% |
| Water Solubility | insoluble |
| Specific Heat Capacity | Cp(crystal): 1.74 J/(g·K), at 25℃ |
| JECFA Number | 114 |
| Merck | 14,2028 |
| BRN | 1748475 |
| Dielectric constant | 3.6（60℃） |
| Stability | Stable. Incompatible with strong oxidizing agents, strong acids. |
| Cosmetics Ingredients Functions |
SURFACTANT - EMULSIFYING VISCOSITY CONTROLLING OPACIFYING SURFACTANT - FOAM BOOSTING FRAGRANCE EMULSION STABILISING SURFACTANT - CLEANSING SKIN CONDITIONING - EMOLLIENT |
| Cosmetic Ingredient Review (CIR) | 1-Hexadecanol (36653-82-4) |
| InChI | 1S/C16H34O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h17H,2-16H2,1H3 |
| InChIKey | BXWNKGSJHAJOGX-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCCCCO |
| LogP | 6.7 |
| CAS DataBase Reference | 36653-82-4(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | CETYL ALCOHOL |
| FDA 21 CFR | 175.105; 175.300; 176.200;177.1200 |
| EWG's Food Scores | 1 |
| FDA UNII | 936JST6JCN |
| NIST Chemistry Reference | 1-Hexadecanol(36653-82-4) |
| EPA Substance Registry System | 1-Hexadecanol (36653-82-4) |
| Cosmetics Info | Cetyl Alcohol |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 38-36/37/38 | |||||||||
| Safety Statements | 22-24/25-37 | |||||||||
| WGK Germany | - | |||||||||
| RTECS | MM0225000 | |||||||||
| Autoignition Temperature | 483 °F | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29051700 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazardous Substances Data | 36653-82-4(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 orally in Rabbit: > 2000 mg/kg LD50 dermal Rabbit > 2000 mg/kg | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
1-Hexadecanol price More Price(84)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W255408 | 1-Hexadecanol ≥99% | 36653-82-4 | 1 each | $58 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.18704 | Cetyl alcohol for synthesis | 36653-82-4 | 100g | $32.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | C0990000 | Cetyl alcohol European Pharmacopoeia (EP) Reference Standard | 36653-82-4 | 300 mg | $254 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.18704 | Cetyl alcohol for synthesis | 36653-82-4 | 1kg | $77.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | 68824 | Cetyl alcohol analytical standard | 36653-82-4 | 1g | $38.7 | 2026-04-30 | Buy |
1-Hexadecanol Chemical Properties,Uses,Production
Uses in Perfume
1-Hexadecanol finds some use in flavor compositions in minute traces in imitation chocolate flavors, mainly to introduce a mouthfeel, rather than a taste. The concentration used is about 2 ppm in the finished product.
Description
1-Hexadecanol is a waxy white powder or flake form at room temperature, and is insoluble in water and soluble in alcohols and oils. Discovered by Chevrenl in 1913, It is one of the oldest known long-chain alcohol. It can be produced from the reduction of palmitic acid. 1-Hexadecanol may be contained in cosmetic and personal care products such as shampoos, creams and lotions. it is mainly used as an opacifier, emulsifier, and thickening agent that alter the thickness of the liquid, and increase and stabilize the foaming capacity.
Chemical Properties
Cetyl alcohol occurs as waxy, white flakes, granules, cubes, or castings. It has a faint characteristic odor and bland taste.
Originator
Hexadecyl alcohol,Esso Res. And Eng. Co.
Occurrence
Reported as a major constituent of spermaceti oil, where it is present chiefy as cetyl palmitate Also reported found in guava, peach, pear, kohlrabi, baked potato, mustard, Parmesan cheese, butter, milk powder, boiled egg, cooked chicken, roasted beef, beef fat, whiskies, tea, starfruit, mango, rice, licorice, kiwifruit, loquat, endive, shrimp, crab, clam, Cape gooseberry and pawpaw
Uses
cetyl alcohol is a versatile ingredient that can serve as an emollient, emulsifier, thickener, binder, foam booster, or emulsion stabilizer, depending on the formulation and need. It is derived from coconut or palm oil as well as being synthetically manufactured. It is considered by some sources to be a non-comedogenic material.
Uses
1-Hexadecanol has been used in preparation of:
(±)-2-methoxyheptadecanoic acid (fatty acid)
high-chain fatty acid esters of 1-hexadecanol, novel organic phase change material for thermal energy storage
hexadecane (alkane) in the presence of membrane fraction of Vibrio furnissii M1
Definition
ChEBI: 1-Hexadecanol is a long chain fatty alcohol that is hexadecane substituted by a hydroxy group at position 1. It is a synthetic, solid, fatty alcohol and nonionic surfactant. It is used as an emulsifying agent in pharmaceutical preparations.
Production Methods
Cetyl alcohol may be manufactured by a number of methods such as esterification and hydrogenolysis of fatty acids or by catalytic hydrogenation of the triglycerides obtained from coconut oil or tallow. Cetyl alcohol may be purified by crystallization and distillation.
Therapeutic Function
Pharmaceutic aid
Synthesis Reference(s)
The Journal of Organic Chemistry, 42, p. 512, 1977 DOI: 10.1021/jo00423a025
Synthetic Communications, 25, p. 1901, 1995 DOI: 10.1080/00397919508015865
Tetrahedron Letters, 24, p. 4485, 1983 DOI: 10.1016/S0040-4039(00)85933-X
General Description
1-Hexadecanol is a free fatty acid alcohol generally used as an emulsifier, emollient, opacifier and surfactant in cosmetics formulations.
Flammability and Explosibility
Not classified
Safety
Cetyl alcohol is mainly used in topical formulations, although it has
also been used in oral and rectal preparations.
Cetyl alcohol has been associated with allergic delayed-type
hypersensitivity reactions in patients with stasis dermatitis. Crosssensitization
with cetostearyl alcohol, lanolin, and stearyl alcohol
has also been reported. It has been suggested that hypersensitivity
may be caused by impurities in commercial grades of cetyl
alcohol since highly refined cetyl alcohol (99.5%) has not been
associated with hypersensitivity reactions.
LD50 (mouse, IP): 1.6 g/kg
LD50 (mouse, oral): 3.2 g/kg
LD50 (rat, IP): 1.6 g/kg
LD50 (rat, oral): 5 g/kg
storage
Cetyl alcohol is stable in the presence of acids, alkalis, light, and air; it does not become rancid. It should be stored in a well-closed container in a cool, dry place.
Purification Methods
Crystallise the alcohol from aqueous EtOH or from cyclohexane. Alternatively purify it by zone refining. The purity can be checked by gas chromatography. [Beilstein 1 H 429, 1 I 219, 1 II 466, 1 III 1815, 1 IV 1876.]
Incompatibilities
Incompatible with strong oxidizing agents. Cetyl alcohol is responsible for lowering the melting point of ibuprofen, which results in sticking tendencies during the process of film coating ibuprofen crystals.
Regulatory Status
Included in the FDA Inactive Ingredients Database (ophthalmic preparations, oral capsules and tablets, otic and rectal preparations, topical aerosols, creams, emulsions, ointments and solutions, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.
1-Hexadecanol Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangxi Alpha Hi-tech Pharmaceutical Co., Ltd | 510-85010237 | overseamarketing@alphahi-tech.com | CHINA | 41 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5220 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Shandong Dexiang International Trade Co., Ltd | +8615662691337 | 539942812@qq.com | China | 998 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 17389186172 | 1077@dideu.com | China | 3796 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 | info@fortunachem.com | China | 5995 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1006 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
View Lastest Price from 1-Hexadecanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-25 | 1-Hexadecanol
36653-82-4
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-07-24 | 1-Hexadecanol
36653-82-4
|
$70.00-110.00 | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2026-07-24 | 1-Hexadecanol
36653-82-4
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- 1-Hexadecanol
36653-82-4
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- 1-Hexadecanol
36653-82-4
- $70.00-110.00
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- 1-Hexadecanol
36653-82-4
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
