Chloroacetic anhydride
- CAS No.
- 541-88-8
- Chemical Name:
- Chloroacetic anhydride
- Synonyms
- 2-Chloroacetic anhydride;Monochloroacetic anhydride;CHLOROACETIC ACID ANHYDRIDE;MONOCHLOROACETIC ACID ANHYDRIDE;NSC 71207;oroacetic anhydride;chloraceticanhydride;Chloracetic anhydride;chloroacetylanhydride;CHLOROACETIC ANHYDRIDE
- CBNumber:
- CB4853783
- Molecular Formula:
- C4H4Cl2O3
- Molecular Weight:
- 170.97
- MDL Number:
- MFCD00000929
- MOL File:
- 541-88-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Chloroacetic anhydride 95% | 215163 | 25g | $237 |
| Chloroacetic anhydride 95% | 215163 | 100g | $386 |
| Chloroacetyl Anhydride | TRC-C327205-25G | 25g | $159 |
| Chloroacetyl Anhydride | TRC-C327205-1G | 1g | $68 |
| Chloroacetyl Anhydride | TRC-C327205-10G | 10g | $84 |
| More product size | |||
| Melting point | 51 °C |
|---|---|
| Boiling point | 203 °C |
| Density | 1.449 |
| vapor pressure | <0.75 mm Hg ( 20 °C) |
| refractive index | 1.4730 (estimate) |
| Flash point | >230 °F |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Freely soluble in ether, chloroform. Slightly soluble in benzene. Insoluble in cold ligroin |
| form | Crystals, Chunks or Low Melting Mass |
| color | brown |
| Sensitive | Moisture Sensitive |
| Merck | 14,2113 |
| BRN | 774533 |
| Henry's Law Constant | 2.2×100 mol/(m3Pa) at 25℃, HSDB (2015) |
| Stability | Moisture Sensitive |
| InChI | 1S/C4H4Cl2O3/c5-1-3(7)9-4(8)2-6/h1-2H2 |
| InChIKey | PNVPNXKRAUBJGW-UHFFFAOYSA-N |
| SMILES | ClCC(=O)OC(=O)CCl |
| CAS DataBase Reference | 541-88-8(CAS DataBase Reference) |
| FDA UNII | 8Q7TXH7R5F |
| EPA Substance Registry System | Acetic acid, chloro-, anhydride (541-88-8) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS06,GHS09 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H311-H314-H331-H400 | |||||||||
| Precautionary statements | P264-P270-P280-P260-P261-P271-P273-P301+P310-P330-P302+P352-P312-P361+P364-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P305+P351+P338-P311-P391-P405-P403+P233-P501 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | C,T | |||||||||
| Risk Statements | 34-36/37-43-25 | |||||||||
| Safety Statements | 26-28-36/37/39-45-27 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-19-21 | |||||||||
| Hazard Note | Highly Toxic/Corrosive/Lachrymator | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29159000 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
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| Hazard Classifications | Acute Tox. 3 Oral Eye Dam. 1 Skin Corr. 1B |
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| Hazardous Substances Data | 541-88-8(Hazardous Substances Data) | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 100ml (liquid) or 0.5 Kg (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
Chloroacetic anhydride price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 215163 | Chloroacetic anhydride 95% | 541-88-8 | 25g | $237 | 2026-04-30 | Buy |
| Sigma-Aldrich | 215163 | Chloroacetic anhydride 95% | 541-88-8 | 100g | $386 | 2026-04-30 | Buy |
| TRC | TRC-C327205-25G | Chloroacetyl Anhydride | 541-88-8 | 25g | $159 | 2026-06-03 | Buy |
| TRC | TRC-C327205-1G | Chloroacetyl Anhydride | 541-88-8 | 1g | $68 | 2026-06-03 | Buy |
| TRC | TRC-C327205-10G | Chloroacetyl Anhydride | 541-88-8 | 10g | $84 | 2026-06-03 | Buy |
Chloroacetic anhydride Chemical Properties,Uses,Production
Chemical Properties
brownish semi-transparent crystals, chunks or low
Uses
Chloroacetic anhydride has been used in the synthesis of 3,3-bis(sulfonato)-4,4-bis(chloroacetamido)azobenzene (BSBCA), a water-soluble, thiol-reactive and photo-switchable cross-linker, D,L-7-azatryptophan, 2-methyl-[3,4-di-O-acetyl-6-O-(chloroacetyl)-1,2-dideoxy-α-D-glucopyrano]-[2,1:4,5]-2-oxazoline.
Uses
In N-acetylation of amino acids in alkaline solution; preparation of cellulose chloroacetates.
Preparation
chloroacetic anhydride Synthesis: Powdered s odium monochloroacetate(113.3g, 1.138 mol) was added slowly for a period of 15 min at room temperature (which slowly raises to 60°C) to a stirred solution of commercially available chloroaceyl chloride (127.5g, 1mol) in dry benzene (136mL) was refluxed for 9h. Salts were filtered off, the filtrate was cooled to room temperature, diluted with n-hexane and further cooled to 0°C. The solid separated was then filtered, washed with dry hexane and dried to yield chloroacetic anhydride as white crystalline compound in 60% yield (80g); mp=46-49°C [Lit. mp=46°C]. Alternatively, the benzene layer was directly subjected to high vacuum distillation.The product collected at 109-10°C at 10mm vacuum on cooling chloroacetic anhydride in lump form in 70 % yield (93g). It was observed that, the latter method gives anhydride in lump form while the former method gives in crystalline form.
Purification Methods
Crystallise the it from *benzene. [Eglinton et al. J Chem Soc 1860 1954, Beilstein 2 IV 487.]
Chloroacetic anhydride Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5220 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6366 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
View Lastest Price from Chloroacetic anhydride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-05-28 | Chloroacetic Anhydride
541-88-8
|
$10.50 | 1KG | 99% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-03-20 | Chloroacetic anhydride
541-88-8
|
$10.00 | 100KG | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2024-04-12 | Chloroacetic anhydride
541-88-8
|
1kg | 97% | 10000 Mt/Year | Shaanxi Haibo Biotechnology Co., Ltd |
-
- Chloroacetic Anhydride
541-88-8
- $10.50
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- Chloroacetic anhydride
541-88-8
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Chloroacetic anhydride
541-88-8
- 97%
- Shaanxi Haibo Biotechnology Co., Ltd
541-88-8(Chloroacetic anhydride)Related Search:
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