N-BOC-2-AMINOPHENOL
- CAS No.
- 186663-74-1
- Chemical Name:
- N-BOC-2-AMINOPHENOL
- Synonyms
- N-Boc-2-aminophenol;tert-Butyl o-hydroxyphenylcarbamate;tert-butyl N-(2-hydroxyphenyl)carbamate;(3-oxo-1lambda3,2-benziodoxol-3-yl)acetate;Carbamic acid, N-(2-hydroxyphenyl)-, 1,1-dimethylethyl ester;Carbamic acid, (2-hydroxyphenyl)-, 1,1-dimethylethyl ester (9CI);2-Hydroxyphenyl carbamic acid tert-butyl ester, N-tert-Butoxycarbonyl-2-aminophenol
- CBNumber:
- CB4972372
- Molecular Formula:
- C11H15NO3
- Molecular Weight:
- 209.24
- MDL Number:
- MFCD06411300
- MOL File:
- 186663-74-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| N-Boc-2-aminophenol 97% | 635960 | 5g | $290 |
| tert-Butyl (2-hydroxyphenyl)carbamate 97% | AS48143 | 1g | $34 |
| tert-Butyl (2-hydroxyphenyl)carbamate 97% | AS48143 | 5g | $126 |
| tert-Butyl (2-hydroxyphenyl)carbamate 97% | AS48143 | 25g | $475 |
| tert-Butyl (2-hydroxyphenyl)carbamate 97% | B54889 | 250mg | $20 |
| Melting point | 140-144 °C (lit.) |
|---|---|
| Boiling point | 265.6±23.0 °C(Predicted) |
| Density | 1.182±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | soluble in Chloroform, Ethyl Acetate, Methanol |
| form | Solid |
| pka | 9.74±0.35(Predicted) |
| color | White |
| InChI | 1S/C11H15NO3/c1-11(2,3)15-10(14)12-8-6-4-5-7-9(8)13/h4-7,13H,1-3H3,(H,12,14) |
| InChIKey | UQLYDIDMLDTUDL-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)Nc1ccccc1O |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H317-H319 |
| Precautionary statements | P280-P302+P352-P305+P351+P338 |
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/38-43 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 Skin Sens. 1 |
N-BOC-2-AMINOPHENOL price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 635960 | N-Boc-2-aminophenol 97% | 186663-74-1 | 5g | $290 | 2026-04-30 | Buy |
| Activate Scientific | AS48143 | tert-Butyl (2-hydroxyphenyl)carbamate 97% | 186663-74-1 | 1g | $34 | 2026-06-04 | Buy |
| Activate Scientific | AS48143 | tert-Butyl (2-hydroxyphenyl)carbamate 97% | 186663-74-1 | 5g | $126 | 2026-06-04 | Buy |
| Activate Scientific | AS48143 | tert-Butyl (2-hydroxyphenyl)carbamate 97% | 186663-74-1 | 25g | $475 | 2026-06-04 | Buy |
| Synthonix | B54889 | tert-Butyl (2-hydroxyphenyl)carbamate 97% | 186663-74-1 | 250mg | $20 | 2026-05-06 | Buy |
N-BOC-2-AMINOPHENOL Chemical Properties,Uses,Production
Uses
N-Boc-2-aminophenol is an Boc protected 2-Aminophenol (A618930), an isomer of 4-Aminophenol (A618920).
Synthesis
24424-99-5
95-55-6
186663-74-1
GENERAL PROCEDURE: Iron(III) trifluoromethanesulfonate (Fe(OTf)3, 1 mol%) was added to a mixture containing o-aminophenol (1 mmol) and di-tert-butyl dicarbonate (Boc2O, 1 mmol) at room temperature with simultaneous magnetic stirring. The reaction mixture was continuously stirred until the reaction was complete (monitored by thin layer chromatography, TLC). After completion of the reaction, the reaction mixture was diluted with ethyl acetate (EtOAc) and washed with water. The organic layer was separated and dried with anhydrous magnesium sulfate (MgSO4). Finally, the solvent was removed by distillation under vacuum to obtain high purity N-Boc-2-aminophenol.
References
[1] Tetrahedron Letters, 2006, vol. 47, # 7, p. 1087 - 1091
[2] Journal of Chemical Research, 2013, vol. 37, # 12, p. 757 - 760
[3] Asian Journal of Chemistry, 2017, vol. 29, # 6, p. 1313 - 1316
[4] Journal of Organic Chemistry, 2002, vol. 67, # 14, p. 4882 - 4892
[5] Comptes Rendus Chimie, 2010, vol. 13, # 5, p. 544 - 547
N-BOC-2-AMINOPHENOL Preparation Products And Raw materials
Raw materials
Preparation Products
N-BOC-2-AMINOPHENOL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8645 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53803 | 58 |
| Shanghai Scibiotron Pharmaceutical Co., Ltd | +86-16621589600 | contact@scibiotron.com | China | 5999 | 58 |
| SHANGHAI YOUNG-CHEM CHEMICAL CO., LTD. | +8613817489192 | hebe@ychemchemical.com | China | 2435 | 58 |
| Yantai Sheng Kai Lun Biological Products Co. , Ltd. | 13356901049 | mark@sklnchem.cn | China | 7951 | 58 |
| Energy Chemical | 021-021-58432009 400-005-6266 | sales8178@energy-chemical.com | China | 44816 | 61 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32321 | 50 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 4710 | 55 |
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