Heptafluorobutyric anhydride
- CAS No.
- 336-59-4
- Chemical Name:
- Heptafluorobutyric anhydride
- Synonyms
- HFAA;PERFLUOROBUTYRIC ANHYDRIDE;2,2,3,3,4,4,4-heptafluorobutanoic anhydride;AKOS B020344;uorobutyric anhydride;Heptafluorotic anhydride;Perfluorobutanoic anhydride;HEPTAFLUOROBUTYRIC ANHYDRIDE;PERFLUORO-N-BUTYRIC ANHYDRIDE;Heptafluorobutanoic anhydride
- CBNumber:
- CB5217287
- Molecular Formula:
- C8F14O3
- Molecular Weight:
- 410.06
- MDL Number:
- MFCD00000432
- MOL File:
- 336-59-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Heptafluorobutyric anhydride for GC derivatization, ≥99.0% | 394912 | 5ml | $187 |
| Heptafluorobutyric Anhydride >95.0%(T) | H0337 | 10g | $85 |
| Heptafluorobutyric Anhydride | TRC-H998573-500MG | 500mg | $78 |
| Heptafluorobutyric Anhydride | TRC-H998573-1G | 1g | $95 |
| Heptafluorobutyric Anhydride | TRC-H998573-100MG | 100mg | $68 |
| More product size | |||
| Melting point | −43 °C(lit.) |
|---|---|
| Boiling point | 108-110 °C(lit.) |
| Density | 1.674 g/mL at 20 °C(lit.) |
| refractive index |
n |
| Flash point | None |
| storage temp. | room temp |
| solubility | Miscible with halogenated solvents. Immiscible with polar solvents. |
| form | Liquid |
| Specific Gravity | 1.653 |
| color | Colorless to Almost colorless |
| Water Solubility | REACTS |
| Sensitive | Hygroscopic |
| BRN | 856036 |
| Stability | Moisture Sensitive |
| InChI | 1S/C8F14O3/c9-3(10,5(13,14)7(17,18)19)1(23)25-2(24)4(11,12)6(15,16)8(20,21)22 |
| InChIKey | UFFSXJKVKBQEHC-UHFFFAOYSA-N |
| SMILES | FC(F)(F)C(F)(F)C(F)(F)C(=O)OC(=O)C(F)(F)C(F)(F)C(F)(F)F |
| CAS DataBase Reference | 336-59-4(CAS DataBase Reference) |
| FDA UNII | H5L67KPX9Z |
| NIST Chemistry Reference | Heptafluorobutyric anhydride(336-59-4) |
| EPA Substance Registry System | Heptafluorobutyric anhydride (336-59-4) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405 | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 3265 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| Hazard Note | Corrosive/Hygroscopic | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29159080 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Skin Corr. 1B | |||||||||
| NFPA 704 |
|
Heptafluorobutyric anhydride price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 394912 | Heptafluorobutyric anhydride for GC derivatization, ≥99.0% | 336-59-4 | 5ml | $187 | 2026-04-30 | Buy |
| TCI Chemical | H0337 | Heptafluorobutyric Anhydride >95.0%(T) | 336-59-4 | 10g | $85 | 2026-04-30 | Buy |
| TRC | TRC-H998573-500MG | Heptafluorobutyric Anhydride | 336-59-4 | 500mg | $78 | 2026-06-03 | Buy |
| TRC | TRC-H998573-1G | Heptafluorobutyric Anhydride | 336-59-4 | 1g | $95 | 2026-06-03 | Buy |
| TRC | TRC-H998573-100MG | Heptafluorobutyric Anhydride | 336-59-4 | 100mg | $68 | 2026-06-03 | Buy |
Heptafluorobutyric anhydride Chemical Properties,Uses,Production
Chemical Properties
clear colorless liquid
Uses
Heptafluorobutyric anhydride (HFAA) is frequently used as an acylating agent for the derivatization of primary and secondary amines (Walle and Ehrsson, 1971). Commercially available Heptafluorobutyric anhydride may afford low yields of the derivative due to the presence of Heptafluorobutyric acid (Moodie et al., 1985). This contaminant may be removed by ditillation over phosphorus pentoxide (Walle and Ehrsson, 1970).
HFAA is used to increase volatility of an analyte, and to introduce fluorine atoms for better detection limits in gas chromatography applications.
suzuki reaction
Uses
Heptafluorobutyric anhydride is used as a derivatization reagent for gas chromatography - mass mass spectrometry analysis of the stereoisomer content of synthetic peptides. It is a GC derivatizing agent used to prepare volatile derivatives of amino acids and other biologically active compounds.
Uses
As a GC derivatizing agent, Heptafluorobutyric anhydride is used to prepare volatile derivatives of amino acids and other biologically active compounds.
Definition
ChEBI: An acyclic carboxylic anhydride that is perfluorinated butyric anhydride. It is used as a derivatising reagent for gas chromatographic analyses.
General Description
Heptafluorobutyric anhydride is a perfluoroacylated acylation reagent, that forms stable, volatile derivatives with alcohols, amines, and phenols. It is majorly used to prepare electron-capturing derivatives for GC/electron capture detection. It is generally used with an acid scavenger, to help drive the reaction to completion and to prevent column damage from acidic by-products of the derivatization reaction. It is also used for the frequent testing of drugs of abuse such as, amphetamines and phencyclidine by GC-MS technique.
reaction suitability
reagent type: derivatization reagent
reaction type: Acylations
Heptafluorobutyric anhydride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
View Lastest Price from Heptafluorobutyric anhydride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-08 | Heptafluorobutyric anhydride
336-59-4
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-04-17 | Heptafluorobutyric anhydride
336-59-4
|
$2.00-5.00 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-03-20 | Heptafluorobutyric anhydride
336-59-4
|
$1.00 | 1kg | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Heptafluorobutyric anhydride
336-59-4
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Heptafluorobutyric anhydride
336-59-4
- $2.00-5.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- Heptafluorobutyric anhydride
336-59-4
- $1.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
