3-Amino-2-chloro-4-methylpyridine
- CAS No.
- 133627-45-9
- Chemical Name:
- 3-Amino-2-chloro-4-methylpyridine
- Synonyms
- 2-CHLORO-4-METHYLPYRIDIN-3-AMINE;Capic;2-CHLORO-3-AMINO-4-METHYLPYRIDINE;CAS:133627-45-9;TIMTEC-BB SBB010194;3-Amino-2-chloro-4-p;ASINEX-REAG BAS 13794917;2-CHLORO-3-AMINO-4-PICOLINE;3-AMINO-2-CHLORO-4-PICOLINE;2-Chloro-3-Amino-4-Methylpyrid
- CBNumber:
- CB5240863
- Molecular Formula:
- C6H7ClN2
- Molecular Weight:
- 142.59
- MDL Number:
- MFCD00673152
- MOL File:
- 133627-45-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-Amino-2-chloro-4-methylpyridine 97% | 708135 | 5g | $66.1 |
| 3-Amino-2-chloro-4-methylpyridine 97% | 708135 | 1g | $24 |
| 3-Amino-2-chloro-4-methylpyridine >98.0%(GC)(T) | A1855 | 5g | $18 |
| 3-Amino-2-chloro-4-methylpyridine >98.0%(GC)(T) | A1855 | 25g | $58 |
| 3-Amino-2-chloro-4-methylpyridine | TRC-A603468-5G | 5g | $135 |
| More product size | |||
| Melting point | 65-70 °C |
|---|---|
| Boiling point | 283.3±35.0 °C(Predicted) |
| Density | 1.260±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Chloroform, Ethanol |
| pka | 3.22±0.10(Predicted) |
| form | Crystals |
| color | Off White |
| InChI | InChI=1S/C6H7ClN2/c1-4-2-3-9-6(7)5(4)8/h2-3H,8H2,1H3 |
| InChIKey | UOBCYTOUXLAABU-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=CC(C)=C1N |
| CAS DataBase Reference | 133627-45-9(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-41-37/38-22 | |||||||||
| Safety Statements | 26-36/37/39-36-39 | |||||||||
| RIDADR | UN2811 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Amino-2-chloro-4-methylpyridine price More Price(87)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 708135 | 3-Amino-2-chloro-4-methylpyridine 97% | 133627-45-9 | 5g | $66.1 | 2023-06-20 | Buy |
| Sigma-Aldrich | 708135 | 3-Amino-2-chloro-4-methylpyridine 97% | 133627-45-9 | 1g | $24 | 2023-01-07 | Buy |
| TCI Chemical | A1855 | 3-Amino-2-chloro-4-methylpyridine >98.0%(GC)(T) | 133627-45-9 | 5g | $18 | 2026-04-30 | Buy |
| TCI Chemical | A1855 | 3-Amino-2-chloro-4-methylpyridine >98.0%(GC)(T) | 133627-45-9 | 25g | $58 | 2026-04-30 | Buy |
| TRC | TRC-A603468-5G | 3-Amino-2-chloro-4-methylpyridine | 133627-45-9 | 5g | $135 | 2026-06-03 | Buy |
3-Amino-2-chloro-4-methylpyridine Chemical Properties,Uses,Production
Chemical Properties
Off White Crystals
Uses
3-Amino-2-chloro-4-methylpyridine, also known as CAPIC, is a key intermediate in the production of nevirapine, a non-nucleosidic reverse transcriptase inhibitor that has been established to be clinically useful for the treatment of infection by HIV-1.
Preparation
An improved and commercially valuable process is developed by Ge et al. for the scalable synthesis of 2-chloro-3-amino-4-methylpyridine (CAPIC), a key intermediate of Nevirapine. The synthesis was accomplished in four steps, featuring condensation starting from 4,4-dimethoxyl-2-butanone and cyanoacetamide with ammonium acetate and acetic acid as catalysts. Specifically, a stirred solution of NaOH (15.6 g, 0.39 mol) and water (85 g) at 10 ℃ was added, 10% NaClO (96.8 g, 0.13 mol) and ethanol (80 g). 2-Chloro-3-amido-4- methylpyridine 7 (22 g, 0.13 mol) was added to the reaction mixture, stirring for 1 h. The mixture was heated to 60 ℃ and held for 3 h. After ethanol was removed in a vacuum, the mixture was cooled with an ice-water bath for 15–20 min to precipitate solid. Then, the mixture was filtered, washed with water, and dried to give 15.8 g (85.1% yield) of light yellow solid. 14.7 g of the white solid 2 was obtained via recrystallization in toluene.
Synthesis
152362-01-1
133627-45-9
General procedure for the synthesis of 2-chloro-3-amino-4-methylpyridine from 2-chloro-4-methylnicotinamide: 61.5 g of calcium hypochlorite was added to the reaction mixture in batches, and after the addition was completed, stirring was continued for 30 minutes at a maintained reaction temperature of 50 °C. Subsequently, 50 mL of 40 wt% aqueous calcium oxide solution was added in batches, the temperature was controlled not to exceed 10 °C, and the reaction lasted for 2 to 3 hours. Upon completion of the reaction, the cooled reaction mixture was slowly added dropwise to 150 mL of water, and the temperature was controlled not to exceed 100 °C during the dropwise addition. After the dropwise addition, the reaction was continued at 70 to 80°C for 2 hours. After the reaction solution was cooled to 5°C, the pH was adjusted to 6.5~7 with concentrated hydrochloric acid. filtration was carried out and the filter cake was washed with ice water. The filter cake was resuspended in 75 mL of water, heated to 60-70°C, stirred for 30 minutes, and then slowly cooled to 0~5°C to precipitate crystals. It was filtered again and the filter cake was washed with ice water and finally dried under vacuum. This process yielded 41.5 g of 2-chloro-3-amino-4-methylpyridine with 99.9% HPLC purity.
References
[1] Xin Ge. “A concise synthesis of 2-chloro-3-amino-4-methylpyridine.” Research on Chemical Intermediates 37 6 (2011): 599–604.
3-Amino-2-chloro-4-methylpyridine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangsu Guiren Medicine Co.,Ltd | +86-13815020719 | guiren_medicine@163.com | China | 212 | 58 |
| shandong exelon biochem co.ld | +86-533-2119995 +8615053330977 | 451614802@QQ.com | China | 96 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Jiangsu Zhongbang Pharmaceutical Co., Ltd. | 025-87151996 | zbsales@chinaredsun.com | CHINA | 32 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 923 | 58 |
| Win-Win Chemical CO., Limited | 0086-577-64498589 | sales@win-winchemical.com | CHINA | 998 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
Related articles
- 3-Amino-2-chloro-4-methylpyridine: Overview and Applications as Drug Intermediates
- 3-Amino-2-chloro-4-methylpyridine is stable under normal conditions, it is a key intermediate in the production of nevirapine.
- Feb 8，2025
- The synthesis method of 3-Amino-2-chloro-4-methylpyridine
- 3-Amino-2-chloro-4-methylpyridine is a key intermediate in the production of nevirapine with various synthesis methods.
- Oct 7，2023
View Lastest Price from 3-Amino-2-chloro-4-methylpyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-08 | 3-Amino-2-chloro-4-methylpyridine
133627-45-9
|
1KG | 98%min | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-05-28 | 2-Chloro-3-amino-4-methyl pyridine
133627-45-9
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-05-05 | 3-Amino-2-chloro-4-methylpyridine
133627-45-9
|
$80.00-800.00 | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd |
-
- 3-Amino-2-chloro-4-methylpyridine
133627-45-9
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2-Chloro-3-amino-4-methyl pyridine
133627-45-9
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 3-Amino-2-chloro-4-methylpyridine
133627-45-9
- $80.00-800.00
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
