1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE
- CAS No.
- 364-11-4
- Chemical Name:
- 1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE
- Synonyms
- 2-Bromo-5-iodobenzotrifluoride;1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE;Benzene, 1-bromo-4-iodo-2-(trifluoromethyl)-;1-Bromo-4-iodo-2-(trifluoromethyl)benzene, 2-Bromo-5-iodo-alpha,alpha,alpha-trifluorotoluene
- CBNumber:
- CB52467048
- Molecular Formula:
- C7H3BrF3I
- Molecular Weight:
- 350.9
- MDL Number:
- MFCD11855999
- MOL File:
- 364-11-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Bromo-5-iodobenzotrifluoride ≥95% | PC51000 | 1g | $21 |
| 2-Bromo-5-iodobenzotrifluoride ≥95% | PC51000 | 5g | $28 |
| 2-Bromo-5-iodobenzotrifluoride ≥95% | PC51000 | 25g | $47 |
| 2-Bromo-5-iodobenzotrifluoride ≥95% | PC51000 | 1g | $21 |
| 2-Bromo-5-iodobenzotrifluoride ≥95% | PC51000 | 5g | $28 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
| HS Code | 2903998090 |
1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC51000 | 2-Bromo-5-iodobenzotrifluoride ≥95% | 364-11-4 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC51000 | 2-Bromo-5-iodobenzotrifluoride ≥95% | 364-11-4 | 5g | $28 | 2026-06-04 | Buy |
| Apolloscientific | PC51000 | 2-Bromo-5-iodobenzotrifluoride ≥95% | 364-11-4 | 25g | $47 | 2026-06-04 | Buy |
| Apolloscientific | PC51000 | 2-Bromo-5-iodobenzotrifluoride ≥95% | 364-11-4 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC51000 | 2-Bromo-5-iodobenzotrifluoride ≥95% | 364-11-4 | 5g | $28 | 2026-06-04 | Buy |
1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE Chemical Properties,Uses,Production
Synthesis
393-36-2
364-11-4
The general procedure for the synthesis of 2-bromo-5-iodobenzotrifluoride from 5-amino-2-bromobenzotrifluoride was as follows: first, 4-bromo-3-(trifluoromethyl)aniline (500 mg, 2.08 mmol) was dissolved in a mixture of preheated concentrated sulfuric acid (37% w/w, 0.51 mL, 4.6 eq.) and water (2.3 mL, concentration = 3.4 M). Under vigorous stirring, the reaction mixture was cooled to -10 °C (using an ice-salt bath), at which point the aniline bisulfate precipitated as a slurry. Subsequently, an aqueous solution of sodium nitrite (NaNO2, 158 mg, 1.1 eq.) was added slowly and dropwise (1.06 mL, concentration = 2.15 M). After continued stirring at -8 °C for 40 min, an aqueous solution of potassium iodide (KI, 495 mg, 1.43 equiv) (0.4 mL, concentration = 8 M) and copper powder (4 mg) were added. The reaction mixture was gradually warmed to room temperature (ice bath removed) and stirred for 30 minutes. Next, the reaction was heated to reflux (102 °C) and kept for 1 hour. Upon completion of the reaction, it was cooled to room temperature, diluted with water and the aqueous layer was extracted with dichloromethane (DCM, 3 x 20 mL). The combined organic phases were washed sequentially with saturated sodium thiosulfate (Na2S2O3, 20 mL) and brine (20 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The crude product was purified by column chromatography (eluent: hexane) to afford the target compound 2-bromo-5-iodobenzotrifluoride in 93% yield (679 mg) as an orange solid. The structure of the product was confirmed by 1H NMR and 13C NMR.
References
[1] Patent: WO2013/167730, 2013, A1. Location in patent: Page/Page column 90
[2] Angewandte Chemie - International Edition, 2009, vol. 48, # 43, p. 8070 - 8073
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 21, p. 9096 - 9104
[4] Patent: WO2016/63300, 2016, A1. Location in patent: Page/Page column 8
[5] Journal of Medicinal Chemistry, 2012, vol. 55, # 1, p. 233 - 249
1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3997 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
View Lastest Price from 1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2024-06-11 | 1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE
364-11-4
|
$1.00 | 1Kg | 98% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2022-01-15 | 1-Bromo-4-iodo-2-trifluoromethylbenzene
364-11-4
|
1KG | 98.5% | 100 tons | Honest Joy Holdings Limited
|
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 |
2019-09-03 | 1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE
364-11-4
|
$7.00 | 1KG | 98% | Career Henan Chemical Co |
-
- 1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE
364-11-4
- $1.00
- 98%
- Shaanxi Dideu Medichem Co. Ltd
-
- 1-Bromo-4-iodo-2-trifluoromethylbenzene
364-11-4
- $0.00
- 98.5%
- Honest Joy Holdings Limited
-
- 1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE
364-11-4
- $7.00
- 98%
- Career Henan Chemical Co
