tert-butyl azetidin-3-ylmethyl(methyl)carbamate
- CAS No.
- 1053655-53-0
- Chemical Name:
- tert-butyl azetidin-3-ylmethyl(methyl)carbamate
- Synonyms
- 3-(N-Boc-Methylaminomethy...;3-[Boc(methyl)aminomethyl]azetidine,95%;3-[Boc(Methyl)aMinoMethyl]azetidine, 95%;N-Boc-1-(3-azetidinyl)-N-methylmethanamine;tert-butyl azetidin-3-ylmethyl(methyl)carbamate;tert-butyl N-(azetidin-3-ylmethyl)-N-methylcarbamate;1,1-Dimethylethyl N-(3-azetidinylmethyl)-N-methylcarbamate;N-(3-Azetidinylmethyl)-N-methylcarbamic acid tert-butyl ester;N-(3-azetidinylMethyl)-n-Methyl-carbaMic acid 1,1-diMethylethyl ester;Carbamic acid, N-(3-azetidinylmethyl)-N-methyl-, 1,1-dimethylethyl ester
- CBNumber:
- CB52490295
- Molecular Formula:
- C10H20N2O2
- Molecular Weight:
- 200.28
- MDL Number:
- MFCD08061967
- MOL File:
- 1053655-53-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Tert-Butyl Azetidin-3-Ylmethyl(Methyl)Carbamate 95% | AA008RY4 | 100mg | $58 |
| Tert-Butyl Azetidin-3-Ylmethyl(Methyl)Carbamate 95% | AA008RY4 | 250mg | $115 |
| Tert-Butyl Azetidin-3-Ylmethyl(Methyl)Carbamate 95% | AA008RY4 | 1g | $343 |
| Tert-Butyl Azetidin-3-Ylmethyl(Methyl)Carbamate 95% | AA008RY4 | 5g | $1380 |
| tert-butyl N-(azetidin-3-ylmethyl)-N-methylcarbamate 97% | P49900 | 100MG | $90 |
| Boiling point | 267℃ |
|---|---|
| Density | 1.012 |
| Flash point | 116℃ |
| storage temp. | 2-8°C(protect from light) |
| pka | 10.86±0.40(Predicted) |
| Appearance | white powder |
| InChI | InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12(4)7-8-5-11-6-8/h8,11H,5-7H2,1-4H3 |
| InChIKey | IIRJNOLNCXOXOR-UHFFFAOYSA-N |
| SMILES | C(OC(C)(C)C)(=O)N(CC1CNC1)C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HazardClass | IRRITANT | |||||||||
| NFPA 704 |
|
tert-butyl azetidin-3-ylmethyl(methyl)carbamate price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA008RY4 | Tert-Butyl Azetidin-3-Ylmethyl(Methyl)Carbamate 95% | 1053655-53-0 | 100mg | $58 | 2026-05-28 | Buy |
| aablocks | AA008RY4 | Tert-Butyl Azetidin-3-Ylmethyl(Methyl)Carbamate 95% | 1053655-53-0 | 250mg | $115 | 2026-05-28 | Buy |
| aablocks | AA008RY4 | Tert-Butyl Azetidin-3-Ylmethyl(Methyl)Carbamate 95% | 1053655-53-0 | 1g | $343 | 2026-05-28 | Buy |
| aablocks | AA008RY4 | Tert-Butyl Azetidin-3-Ylmethyl(Methyl)Carbamate 95% | 1053655-53-0 | 5g | $1380 | 2026-05-28 | Buy |
| ACHEMBLOCK | P49900 | tert-butyl N-(azetidin-3-ylmethyl)-N-methylcarbamate 97% | 1053655-53-0 | 100MG | $90 | 2026-05-27 | Buy |
tert-butyl azetidin-3-ylmethyl(methyl)carbamate Chemical Properties,Uses,Production
Uses
Tert-butyl azetidin-3-ylmethyl(methyl)carbamate is an important organic reagent that can be used as a building block for the synthesis of tert-butyl ((1-((4-chloro-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)azetidin-3-yl)methyl)(methyl)carbamate which is an important intermediate of a selective small-molecule PLK inhibitors useful in the treatment of cell proliferative disorders.
Synthesis
A solution of tert-butyl ((1-benzhydrylazetidin-3-yl)methyl)carbamate (6.18 g, 17.53 mmol) in 50 mL of MeOH and 15 mL of EtOAc was purged with argon. Pd/C (10%, 50% in water) (929 mg) was added and the mixture was then purged again with argon and stirred in an H2 atmosphere for 18 h. The reaction was filtered through Ceitte and the filter was washed with EtOAc and MeOH, The resulting solvent was evaporated to dryness, providing 5.66 g of a mixture of tert-butyl azetidin-3-ylmethyl(methyl)carbamate together with one equivalent of diphenylmethane. The pure product tert-butyl azetidin-3-ylmethyl(methyl)carbamate was obtained after further purification.
tert-butyl azetidin-3-ylmethyl(methyl)carbamate Preparation Products And Raw materials
Raw materials
Preparation Products
tert-butyl azetidin-3-ylmethyl(methyl)carbamate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boc Chemical Co., Ltd. | 021-34975602; +8618721111801 | shangli@bocchem.com | China | 138 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Protheragen-ING | +16313385890 | info@protheragen-ing.com | United States | 3868 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| Mainchem Co., Ltd. | -- | sarah@mainchem.com | China | 6545 | 58 |
