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ChemicalBook >> CAS DataBase List >>Fostamatinib

Fostamatinib

CAS No.
901119-35-5
Chemical Name:
Fostamatinib
Synonyms
FostaMatinib DisodiuM;R788;RT788;CS-883;R7935788;R-935788;R788 5MG;Tavalisse);NSC-745942;Fostatinib
CBNumber:
CB52499223
Molecular Formula:
C23H26FN6O9P
Molecular Weight:
580.46
MDL Number:
MFCD16628163
MOL File:
901119-35-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:09:40
Product description Number Pack Size Price
Fostamatinib 474099 100mg $1423
Fostamatinib TRC-F112360-5MG 5mg $564
Fostamatinib TRC-F112360-2.5MG 2.5mg $326
Fostamatinib FF104227 0.1g $246.62
Fostamatinib FF104227 0.25g $519.2
More product size

Fostamatinib Properties

Melting point 214° - 217°C
Boiling point 814.2±75.0 °C(Predicted)
Density 1.496
storage temp. -20°C, Hygroscopic
solubility DMSO (Slightly), Methanol (Slightly)
pka 1.70±0.10(Predicted)
form Solid
color White to Off-White
Stability Hygroscopic
InChIKey GKDRMWXFWHEQQT-UHFFFAOYSA-N
SMILES O1C(C)(C)C(=O)N(COP(O)(O)=O)C2=NC(NC3C(F)=CN=C(NC4=CC(OC)=C(OC)C(OC)=C4)N=3)=CC=C12
NCI Dictionary of Cancer Terms fostamatinib disodium
FDA UNII SQ8A3S5101
NCI Drug Dictionary fostamatinib disodium
ATC code B02BX09

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

Fostamatinib price More Price(77)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 474099 Fostamatinib 901119-35-5 100mg $1423 2026-06-03 Buy
TRC TRC-F112360-5MG Fostamatinib 901119-35-5 5mg $564 2026-06-03 Buy
TRC TRC-F112360-2.5MG Fostamatinib 901119-35-5 2.5mg $326 2026-06-03 Buy
Biosynth FF104227 Fostamatinib 901119-35-5 0.1g $246.62 2026-06-04 Buy
Biosynth FF104227 Fostamatinib 901119-35-5 0.25g $519.2 2026-06-04 Buy
Product number Packaging Price Buy
474099 100mg $1423 Buy
TRC-F112360-5MG 5mg $564 Buy
TRC-F112360-2.5MG 2.5mg $326 Buy
FF104227 0.1g $246.62 Buy
FF104227 0.25g $519.2 Buy

Fostamatinib Chemical Properties,Uses,Production

Binding Mode

As shown in the co-crystal structure of tamatinib-SYK (Fig. 1), the aminopyrimidine moiety forms two hydrogen bonds with Ala451 of the hinge region. In addition, there is an atypical hydrogen bond (CH...O=C) between CH at 6 and amide carbonyl of Glu449 (Fig. 2).
Figure 1. Co-crystal structure of tamatinib (parent drug of fostamatinib) with SYK (PDB ID: 3FQS).Figure 2. Summary of tamatinib–SYK interactions based on their co-crystal structure

Uses

Fostamatinib can be used to treat cancers that have acquired resistance to kinase inhibitors.

Indications

Fostamatinib is an FDA-approved first-in-class spleen tyrosine kinase (SYK) inhibitor, specifically indicated for the treatment of adult patients with chronic immune thrombocytopenia (ITP) who have not responded adequately to prior therapies.

brand name

Tavalisse

General Description

Class: non-receptor tyrosine kinase; Treatment: ITP; Other name: R788; Oral bioavailability = 100% (prodrug); Elimination half-life = 15 h (tamatinib); Protein binding = 98.3%

Biological Activity

fostamatinib is a small molecule inhibitor of spleen tyrosine kinase (syk) with ic50 value of 41nm [1].fostamatinib is an orally bioavailable prodrug of r406. it is developed for the treatment of autoimmune diseases. the effective metabolite of fostamatinib, r406, is an atp-competitive inhibitor of syk with ki value of 30nm. r406 also inhibits the activity of other kinases including flt3, lyn (ic50=63nm) and lck (ic50=37nm). it is found that r406 inhibits both bcr and fcr mediated responses in vitro. besides that, r406 also shows effects in other cells types and signalling pathways. in the in vivo assay, fostamatinib shows to be highly active to inhibit fcr-mediated signaling in various animal models of allergy, autoimmunity and inflammation. moreover, fostamatinib also exerts efficacy in sle animal models. treatment of fostamatinib suppresses the established renal and skin disease and reduces lymphadenopathy in the mrl/lpr strain [1].

target

Primary target: SYK

References

[1] mcadoo s p, tam f w k. fostamatinib disodium. drugs of the future, 2011, 36(4): 273.

901119-38-8
901119-35-5
Synthesis of Fostamatinib from Ditert-butyl [6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxo-pyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate
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  • Fostamatinib is an inhibitor of spleen tyrosine kinase (SYK), a key regulator of signal transduction pathways involved in vari....
  • Dec 26，2023

View Lastest Price from Fostamatinib manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Fostamatinib pictures 2026-06-09 Fostamatinib
901119-35-5
 1g 98%min 1000g WUHAN FORTUNA CHEMICAL CO., LTD
Fostamatinib pictures 2026-05-15 Fostamatinib
901119-35-5
 $36.00-81.00 99.58% 10g TargetMol Chemicals Inc.
Fostamatinib (R788) pictures 2025-08-21 Fostamatinib (R788)
901119-35-5
 10g 99% HPLC 1000kg HangZhou RunYan Pharma Technology Co.,LTD.
  • Fostamatinib pictures
  • Fostamatinib
    901119-35-5
  • $0.00
  • 98%min
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • Fostamatinib pictures
  • Fostamatinib
    901119-35-5
  • $36.00-81.00
  • 99.58%
  • TargetMol Chemicals Inc.

Fostamatinib Spectrum

Fostamatinib FostaMatinib (R788) NSC-745942 R-935788 R7935788 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one (6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-3-oxo-2,3-dihydropyrido[3,2-b][1,4]oxazin-4-yl)methyl dihydrogen phosphate R788, >=99% FOSTAMATINIB (R788);R788 R788 5MG Tavalisse) {[6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]py rimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2H,3H,4H- pyrido[3,2-b][1,4]oxazin-4-yl]methoxy}phosphonic acid sodium (6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl)methyl phosphate Fostamatinib USP/EP/BP 2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]- R788 free base R788 (Fostamatinib, FosD, tamatinib fosdium) CS-883 R 788;R-788;R788 [6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate RT788 Blessing him Fostatinib 13C,2H3]-Fostamatinib (6-((5-Fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methyl dihydrogen phosphate?, Fostamatinib (6-((5-Fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methyl dihydrogen phosphate Fostamatinib, 10 mM in DMSO FostaMatinib DisodiuM R788 901119-35-5 C23H26FN6O9P Inhibitors API
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