GW 627368X
- CAS No.
- 439288-66-1
- Chemical Name:
- GW 627368X
- Synonyms
- CS-1654;GW 627368;GW 627368X;GW627368(GW627368X);GW627368, 10 mM in DMSO;GW 627368;GW-627368;GW627368;GW-627368X;GW627368X;GW 627368X;inhibit,Inhibitor,Prostaglandin Receptor,GW627368,GW 627368,GW-627368;N-(benzenesulfonyl)-2-[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)phenyl]acetamide;2-(4-(4,9-Diethoxy-1-oxo-1H-benzo[f]isoindol-2(3H)-yl)phenyl)-N-(phenylsulfonyl)acetamide;N-(benzenesulfonyl)-2-(4-{4,9-diethoxy-1-oxo-1H,2H,3H-benzo[f]isoindol-2-yl}phenyl)acetamide
- CBNumber:
- CB52591190
- Molecular Formula:
- C30H28N2O6S
- Molecular Weight:
- 544.62
- MDL Number:
- MFCD12912327
- MOL File:
- 439288-66-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| GW 627368X ≥96% | 10009162 | 1mg | $65 |
| GW 627368X ≥96% | 10009162 | 5mg | $279 |
| GW 627368X ≥96% | 10009162 | 10mg | $493 |
| GW 627368X ≥96% | 10009162 | 25mg | $1077 |
| GW 627368X ≥96% | 10009162 | 1mg | $59 |
| More product size | |||
| Density | 1.327±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO : 100 mg/mL (183.61 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) |
| form | Powder |
| pka | 5.25±0.10(Predicted) |
| color | White to off-white |
| InChIKey | XREWXJVMYAXCJV-UHFFFAOYSA-N |
| SMILES | O=C(CC1=CC=C(C=C1)N(C2=O)CC3=C2C(OCC)=C4C=CC=CC4=C3OCC)NS(=O)(C5=CC=CC=C5)=O |
| FDA UNII | A9P1ZGY0SE |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
GW 627368X price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10009162 | GW 627368X ≥96% | 439288-66-1 | 1mg | $65 | 2026-04-30 | Buy |
| Cayman Chemical | 10009162 | GW 627368X ≥96% | 439288-66-1 | 5mg | $279 | 2026-04-30 | Buy |
| Cayman Chemical | 10009162 | GW 627368X ≥96% | 439288-66-1 | 10mg | $493 | 2026-04-30 | Buy |
| Cayman Chemical | 10009162 | GW 627368X ≥96% | 439288-66-1 | 25mg | $1077 | 2026-04-30 | Buy |
| Cayman Chemical | 10009162 | GW 627368X ≥96% | 439288-66-1 | 1mg | $59 | 2024-03-01 | Buy |
GW 627368X Chemical Properties,Uses,Production
Description
The effects of prostaglandin E2 (PGE2) are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4. GW 627368X is a potent and selective competitive antagonist of the EP4 receptor with additional human TP receptor affinity. In competition radioligand bioassays, GW 627368X had affinity for human EP4 and TP receptors with Ki values of 100 nM and 158 nM, respectively. Affinity for all other human prostanoid receptors is >5.0 μM. In human washed platelets, GW 627368X produced 100% inhibition of U-
Uses
GW 627368 is a selective EP4 receptor competitive antagonist.
in vivo
GW627368 (GW627368X) (0-15 mg/kg; p.o.; every alternate day for 28 days) shows significant tumor regression characterized by tumor reduction and induction of apoptosis[3].
| Animal Model: | 6-8 weeks Swiss albino mice[3] |
| Dosage: | 0 mg/kg, 5 mg/kg, 10 mg/kg, 15 mg/kg, 15 mg/kg |
| Administration: | Oral administration, every alternate day for 28 days |
| Result: | Displayed anti-tumor and anti-proliferative potential in sarcoma 180 bearing mice. |
IC 50
EP
References
[1] RICHARD J WILSON. GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist[J]. British Journal of Pharmacology, 2009, 148 3: 326-339. DOI: 10.1038/sj.bjp.0706726
GW 627368X Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20405 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11680 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 9948 | 58 |
View Lastest Price from GW 627368X manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | GW627368
439288-66-1
|
$30.00-79.00 | 99.92% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-01-14 | GW 627368X
439288-66-1
|
$7.00 | 1KG | 99% | 1000kg | Career Henan Chemical Co |
-
- GW627368
439288-66-1
- $30.00-79.00
- 99.92%
- TargetMol Chemicals Inc.
-
- GW 627368X
439288-66-1
- $7.00
- 99%
- Career Henan Chemical Co
