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Alpelisib (BYL719)

Alpelisib (BYL719) structure

CAS No.: 1217486-61-7

Chemical Name:: Alpelisib (BYL719)

Synonyms: Alpelisib;Piqray;BYL-719;Alpelisib (BYL719);(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide;(S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxaMide;100803;CS-614;BLV-719;BYL-719 /BYL719

CBNumber:: CB52604234

Molecular Formula:: C19H22F3N5O2S

Molecular Weight:: 441.47

MDL Number:: MFCD22417085

MOL File:: 1217486-61-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:30:55

Product description	Number	Pack Size	Price
BYL719 ≥98%	16986	5mg	$32
BYL719 ≥98%	16986	10mg	$58
BYL719 ≥98%	16986	25mg	$104
BYL719 ≥98%	16986	50mg	$128
BYL719 ≥98%	16986	5mg	$54
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Alpelisib (BYL719) Properties

Density	1.391
storage temp.	Store at -20°C
solubility	≥22.07 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form	White solid.
pka	6.29±0.70(Predicted)
color	Off-white to light yellow
InChIKey	STUWGJZDJHPWGZ-LBPRGKRZSA-N
SMILES	N1(C(NC2=NC(C)=C(C3C=CN=C(C(C)(C)C(F)(F)F)C=3)S2)=O)CCC[C@H]1C(N)=O
NCI Dictionary of Cancer Terms	alpelisib
FDA UNII	08W5N2C97Q
NCI Drug Dictionary	alpelisib
ATC code	L01EM03

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H373
Precautionary statements	P260-P314-P501
HS Code	29341000

Alpelisib (BYL719) price More Price(98)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	16986	BYL719 ≥98%	1217486-61-7	5mg	$32	2026-04-30	Buy
Cayman Chemical	16986	BYL719 ≥98%	1217486-61-7	10mg	$58	2026-04-30	Buy
Cayman Chemical	16986	BYL719 ≥98%	1217486-61-7	25mg	$104	2026-04-30	Buy
Cayman Chemical	16986	BYL719 ≥98%	1217486-61-7	50mg	$128	2026-04-30	Buy
Cayman Chemical	16986	BYL719 ≥98%	1217486-61-7	5mg	$54	2024-03-01	Buy

Product number	Packaging	Price	Buy
16986	5mg	$32	Buy
16986	10mg	$58	Buy
16986	25mg	$104	Buy
16986	50mg	$128	Buy
16986	5mg	$54	Buy

Alpelisib (BYL719) Chemical Properties,Uses,Production

Description

BYL719 is an inhibitor of phosphoinositide 3-kinase α (PI3Kα; IC₅₀s = 4.6, 4, and 4.8 nM for wild-type, E545K mutant, and H1047R mutant PI3K, respectively). It is selective for PI3Kα over PI3Kβ, PI3Kδ, PI3Kγ, and PI4Kβ (IC₅₀s = 1,156, 290, 250, and 581 nM, respectively), as well as VPS34, mTOR, DNA-PK, and ATR (IC₅₀s = >9,100 nM for all). BYL719 (12.5, 25, and 50 mg/kg) reduces tumor volume in a PI3Kα-dependent Rat1-myr-p110α mouse xenograft model. It also reduces tumor burden in THP-1 acute myeloid leukemia (AML) and MCF-7 breast cancer mouse xenograft models. Formulations containing BYL719 have been used in the treatment of advanced or metastatic breast cancer.

Uses

(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide is a newly developed phosphatidylinositol-3-kinase (PI3K) inhibitor and a mTOR inhibitor for the treatment of proliferative diseases.

Definition

ChEBI: (2S)-N1-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)-4-pyridinyl]-2-thiazolyl]pyrrolidine-1,2-dicarboxamide is a proline derivative.

brand name

Piqray

General Description

Class: lipid kinase; Treatment: breast cancer; Other name: NVP-BYL719; Elimination half-life = 13.7 h; Protein binding = 89%

Synthesis

Synthesis of Alpelisib (BYL719)
Alpelisib (BYL719) synthesis

target

PI3Kα

References

1. furet p, guagnano v, fairhurst ra et al. discovery of nvp-byl719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation. bioorg med chem lett 2013; 23: 3741-3748. 2. azab f, vali s, abraham j et al. pi3kca plays a major role in multiple myeloma and its inhibition with byl719 decreases proliferation, synergizes with other therapies and overcomes stroma-induced resistance. br j haematol 2014; 165: 89-101. 3. juric d, argiles g, burris h et al. phase i study of byl719, an alpha-specific pi3k inhibitor, in patients with pik3ca mutant advanced solid tumors: preliminary efficacy and safety in patients with pik3ca mutant er-positive (er+) metastatic breast cancer (mbc). cancer res 2012; 72: p6-10.

Alpelisib (BYL719) Preparation Products And Raw materials

Raw materials

Acetamide,N-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]- 4-Methyl-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine 4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine 4-methyl-2-(2,2,2-trifluoro-1-methyl-1-trimethylsilanyloxy-ethyl)pyridine 1,1,1-trifluoro-2-(4-methylpyridin-2-yl)propan-2-ol

1,1,1-trifluoro-2-(4-methylpyridin-2-yl)propan-2-yl methanesulfonate N-(4-Methyl-5-(2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)-1H-iMidazole-1-carboxaMide phenyl 4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-ylcarbamate L-Prolinamide 1-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)propan-2-one

2-Acetyl-4-methylpyridine 2,4-Lutidine

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Preparation Products

Alpelisib (BYL719) Suppliers

Global( 263)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850	info@fortunachem.com	China	5983	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	9948	58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	+86-18600796368	sales@sjar-tech.com	China	529	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16512	58
Hefei Lbao Physical & Chemical Science Co.,Ltd	+15184799099	lbaochemicals@gmail.com	China	670	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19936	58
Xi'an Yutbon Pharmaceutical Technology Co., Ltd	029-81140587 +8618717328141	sales@yutbon.com	China	454	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58

Supplier	Advantage
Wuhan Fortuna Chemical Co., Ltd	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Hefei Lbao Physical & Chemical Science Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
BOC Sciences	58
Xi'an Yutbon Pharmaceutical Technology Co., Ltd	58
TargetMol Chemicals Inc.	58

An orally PI3K inhibitor: Alpelisib
Alpelisib -an orally available phosphatidylinositol 3-kinase (PI3K) inhibitor with specific activity against PI3K alpha (PI3Kα....
Jan 17，2024

View Lastest Price from Alpelisib (BYL719) manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-09	Alpelisib 1217486-61-7	1G	98%min	30kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-05-20	Alpelisib 1217486-61-7	1g	More Than 99%	50kg/Month	BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
2026-05-20	Alpelisib. 1217486-61-7	1g	More Than 99%	50kg/Month	BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Alpelisib
1217486-61-7
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Alpelisib
1217486-61-7
$0.00
More Than 99%
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Alpelisib.
1217486-61-7
$0.00
More Than 99%
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Alpelisib (BYL719) Spectrum

Alpelisib (BYL719)(1217486-61-7)¹HNMR

1217486-61-7( Alpelisib (BYL719))Related Search:

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BYL-719 /BYL719 BLV-719 1,2-Pyrrolidinedicarboxamide, N1-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-, (2S)- (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide BYL-719 BYL-719 (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide BYL-719(Alpelisib) (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)-pyridin-4-yl)thiazol-2-yl)pyrrolid ALPELISIB;BYL-719; BYL 719 CS-614 Alpelisib - NVP-BYL719 | BYL-719 100803 (2S)-1-N-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Alpelisib, 98%, a potent and selective PI3Kα inhibitor (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide ISO 9001：2015 REACH Alpelisib (BLY-719 (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidine Piqray Inhibitor,Phosphoinositide 3-kinase,PI3K,Alpelisib,inhibit,phosphorylation,p110α,cancer,BYL 719,antineoplastic,AKT,metastasis,mutant,BYL719,PIK3CA,breast (2S) - N1- [4-methyl-5- [2- (2,2,2-trifluoro-1,1-dimethylethyl) -4-pyridyl] -2-thiazolyl] -1,2-pyrrolidine dicarboxylamide Biopterin Impurity 2 Alpelisib, 10 mM in DMSO Byl-719/Alpelisib, Free Base (2S)-1-N-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide - [AC77664] BYL-719 (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxaMide Alpelisib (BYL719) Alpelisib 1217486-61-7 C19H22F3N5O2S Inhibitors Akt mTOR PI3K PI3K/Akt/mTOR Api API

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