SUN11602
- CAS No.
- 704869-38-5
- Chemical Name:
- SUN11602
- Synonyms
- CS-2504;SUN11602;SUN11602;SUN11602;SUN11602, 10 mM in DMSO;inhibit,Fibroblast growth factor receptor,SUN11602,FGFR,Inhibitor,SUN-11602;4-[[4-[[2-(4-amino-2,3,5,6-tetramethylanilino)acetyl]-methylamino]piperidin-1-yl]methyl]benzamide;4-[[4-[[2-[(4-Amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]benzamide;Benzamide, 4-[[4-[[2-[(4-amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]-
- CBNumber:
- CB52731145
- Molecular Formula:
- C26H37N5O2
- Molecular Weight:
- 451.60428
- MDL Number:
- MFCD28133375
- MOL File:
- 704869-38-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| SUN11602 ≥98% | 36572 | 5mg | $62 |
| SUN11602 ≥98% | 36572 | 10mg | $97 |
| SUN11602 ≥98% | 36572 | 25mg | $183 |
| SUN11602 ≥98% | 36572 | 50mg | $304 |
| SUN 11602 Asreported | 256781 | 10mg | $466 |
| Boiling point | 679.8±55.0 °C(Predicted) |
|---|---|
| Density | 1.19±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: soluble |
| form | A crystalline solid |
| pka | 16.19±0.50(Predicted) |
| color | Light yellow to yellow |
| InChI | 1S/C26H37N5O2/c1-16-18(3)25(19(4)17(2)24(16)27)29-14-23(32)30(5)22-10-12-31(13-11-22)15-20-6-8-21(9-7-20)26(28)33/h6-9,22,29H,10-15,27H2,1-5H3,(H2,28,33) |
| InChIKey | KCODNOOPOPTZMO-UHFFFAOYSA-N |
| SMILES | N2(CCC(CC2)N(C)C(=O)CNc3c(c(c(c(c3C)C)N)C)C)Cc1ccc(cc1)C(=O)N |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SUN11602 price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 36572 | SUN11602 ≥98% | 704869-38-5 | 5mg | $62 | 2026-04-30 | Buy |
| Cayman Chemical | 36572 | SUN11602 ≥98% | 704869-38-5 | 10mg | $97 | 2026-04-30 | Buy |
| Cayman Chemical | 36572 | SUN11602 ≥98% | 704869-38-5 | 25mg | $183 | 2026-04-30 | Buy |
| Cayman Chemical | 36572 | SUN11602 ≥98% | 704869-38-5 | 50mg | $304 | 2026-04-30 | Buy |
| Usbiological | 256781 | SUN 11602 Asreported | 704869-38-5 | 10mg | $466 | 2026-06-03 | Buy |
SUN11602 Chemical Properties,Uses,Production
Uses
SUN 11602 is a novel aniline compound, which mimics the neuroprotective mechanisms of basic fibroblast growth factor.
Biological Activity
SUN11602 is an orally active basic fibroblast growth factor (bFGF, FGF2) mimetic th at protects against glutamate toxicity in primary r at cerebrocortical neuron (0.1-1 μM SUN11602; 150 μM glutamate) and murine hippocampal neuron cultures (0.3-3 μM SUN11602; 100 μM glutamate). When administered in vivo, SUN11602 exhibits therapeutic efficacy in a r at hippocampal-lesion model (1-10 mg/kg p.o. 24h post Aβ1-40 injection) and a murine MPTP-induced nigrostriatal degeneration model (2.5-5 mg/kg/day p.o.).
in vivo
In WT mice, SUN11602 increases the levels of newly synthesized Calb in cerebrocortical neurons and suppresses the glutamate-induced rise in intracellular Ca2+. This Ca2+-capturing ability of Calb allows the neurons to survive severe toxic conditions of glutamate[1]. Oral administration of SUN11602 at the midpoint of Aβ1-40 and ibotenate injections attenuate short-term memory impairment in the Y-maze test, as well as spatial learning deficits in the water maze task. In addition, the SUN11602 treatment inhibits the increase of peripheral-type benzodiazepine-binding sites (PTBBS),which are a marker for gliosis[3].
SUN11602 Preparation Products And Raw materials
Raw materials
Preparation Products
SUN11602 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Chengdu Henghui Pharm Tec Co. Ltd. | 13540674322 15828370308 | CHINA | 121 | 55 | |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 |
