4-(7-methoxyquinolin-4-yl)-2-methylphenol
- CAS No.
- 2165340-32-7
- Chemical Name:
- 4-(7-methoxyquinolin-4-yl)-2-methylphenol
- Synonyms
- CU-CPT-9b;cas 2165340-32-7;CU-CPT-9B, CPD2004;CU-CPT9a >=98% (HPLC);CU-CPT-9a, 10 mM in DMSO;(7-methoxyquinolin-4-yl)-2-methylphenol;2-Methyl-4-(7-methoxy-4-quinolinyl)phenol;4-(7-methoxyquinolin-4-yl)-2-methylphenol;CU-CPT-9B;CAS 2165340-32-7 ;TLR8 INHIBITOR;Phenol, 4-(7-methoxy-4-quinolinyl)-2-methyl-
- CBNumber:
- CB53369684
- Molecular Formula:
- C17H15NO2
- Molecular Weight:
- 265.31
- MDL Number:
- MFCD31689252
- MOL File:
- 2165340-32-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| CU-CPT9a ≥98% | 28722 | 1mg | $36 |
| CU-CPT9a ≥98% | 28722 | 5mg | $110 |
| CU-CPT9a ≥98% | 28722 | 10mg | $203 |
| CU-CPT9a ≥98% | 28722 | 25mg | $420 |
| CU-CPT9a | 28722 | 5mg | $100 |
| More product size | |||
| Boiling point | 429.7±45.0 °C(Predicted) |
|---|---|
| Density | 1.201±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml |
| form | A crystalline solid |
| pka | 8.47±0.20(Predicted) |
| color | Light yellow to yellow |
| InChI | 1S/C17H15NO2/c1-11-9-12(3-6-17(11)19)14-7-8-18-16-10-13(20-2)4-5-15(14)16/h3-10,19H,1-2H3 |
| InChIKey | HNYBTVKYLVLWCB-UHFFFAOYSA-N |
| SMILES | CC1=CC(C2=CC=NC3=CC(OC)=CC=C23)=CC=C1O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
4-(7-methoxyquinolin-4-yl)-2-methylphenol price More Price(73)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28722 | CU-CPT9a ≥98% | 2165340-32-7 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 28722 | CU-CPT9a ≥98% | 2165340-32-7 | 5mg | $110 | 2026-04-30 | Buy |
| Cayman Chemical | 28722 | CU-CPT9a ≥98% | 2165340-32-7 | 10mg | $203 | 2026-04-30 | Buy |
| Cayman Chemical | 28722 | CU-CPT9a ≥98% | 2165340-32-7 | 25mg | $420 | 2026-04-30 | Buy |
| Cayman Chemical | 28722 | CU-CPT9a | 2165340-32-7 | 5mg | $100 | 2024-03-01 | Buy |
4-(7-methoxyquinolin-4-yl)-2-methylphenol Chemical Properties,Uses,Production
Uses
CU-CPT9a is a potent TLR8 inhibitor (IC50 = 0.5 nM and Kd = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.
Biological Activity
CU-CPT9a is a potent and selective inhibitor of Toll-like receptor 8 (TLR8). It binds to TLR8 at a site different from current small-molecule TLR7/8 agonists, stabilizing the TLR8 dimer in its resting state, thus preventing TLR8 activation It exhibited an IC50 value of 0.5 nM and blocked TLR8 activation induced by either resiquimod (R848) or ssRNA without affecting the closely related TLR7 or cells expressing other TLRs. CU-CPT9a also suppressed TNF-α levels in a dose-dependent manner in cells from patients with rheumatoid arthritis.
IC 50
TLR8: 0.5 nM (IC50)
storage
Store at -20°C
4-(7-methoxyquinolin-4-yl)-2-methylphenol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
