1-METHYLCYTOSIN
- CAS No.
- 1122-47-0
- Chemical Name:
- 1-METHYLCYTOSIN
- Synonyms
- NSC 47693;1-METHYLCYTOSIN;1-METHYLCYTOSINE;N1-Methylcytosine;RARECHEM AQ NN 0292;4-amino-1-methylpyrimidin-2-one;1-Methylcytosine, 10 mM in DMSO;4-amino-1-methyl-pyrimidin-2-one;4-azanyl-1-methyl-pyrimidin-2-one;4-Amino-1-methyl-2(1H)-pyrimidinone
- CBNumber:
- CB5360974
- Molecular Formula:
- C5H7N3O
- Molecular Weight:
- 125.13
- MDL Number:
- MFCD00038058
- MOL File:
- 1122-47-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Amino-1-methylpyrimidin-2(1H)-one | TRC-A898218-50MG | 50mg | $153 |
| 4-Amino-1-methylpyrimidin-2(1H)-one | TRC-A898218-10MG | 10mg | $59 |
| 4-Amino-1-methylpyrimidin-2(1H)-one | TRC-A898218-100MG | 100mg | $230 |
| 1-Methylcytosine ≥97% | CS-W006395 | 100mg | $90 |
| 1-Methylcytosine ≥97% | CS-W006395 | 250mg | $199 |
| Melting point | 300-303℃ |
|---|---|
| Boiling point | 242℃ |
| Density | 1.34 |
| Flash point | 100℃ |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Solid |
| pka | 4.53±0.10(Predicted) |
| color | White to Off-White |
| FDA UNII | 1J54NE82RV |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| HS Code | 2933399990 |
1-METHYLCYTOSIN price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-A898218-50MG | 4-Amino-1-methylpyrimidin-2(1H)-one | 1122-47-0 | 50mg | $153 | 2026-06-03 | Buy |
| TRC | TRC-A898218-10MG | 4-Amino-1-methylpyrimidin-2(1H)-one | 1122-47-0 | 10mg | $59 | 2026-06-03 | Buy |
| TRC | TRC-A898218-100MG | 4-Amino-1-methylpyrimidin-2(1H)-one | 1122-47-0 | 100mg | $230 | 2026-06-03 | Buy |
| ChemScene | CS-W006395 | 1-Methylcytosine ≥97% | 1122-47-0 | 100mg | $90 | 2026-06-04 | Buy |
| ChemScene | CS-W006395 | 1-Methylcytosine ≥97% | 1122-47-0 | 250mg | $199 | 2026-06-04 | Buy |
1-METHYLCYTOSIN Chemical Properties,Uses,Production
Uses
1-Methylcytosine is a methylated form of the DNA base cytosine and used as a nucleobase of hachimoji DNA, in which it pairs with Isoguanine[1][2].
Definition
ChEBI: A pyrimidone that is cytosine in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group.
Synthesis
77738-01-3
1122-47-0
4-N-(N,N-dimethylaminomethylene)-1-methylcytosine (1.0 g, 5.5 mmol) was added to a 100 mL round bottom flask equipped with a magnetic stirrer along with an ethanol solution (50 mL) containing 30% methylamine. The reaction mixture was stirred at room temperature for 12 hours. Upon completion of the reaction, the precipitated white solid was collected by filtration and purified by recrystallization using ethanol-water solvent mixture. 4-Amino-1-methylpyrimidin-2(1H)-one was finally obtained as a white solid (0.61 g, 88% yield). The structure of the product was analyzed by 1H NMR (400 MHz, DMSO-d6): δ3.31 (s, 3H), 5.59 (d, 1H), 6.91 (br, 2H), 7.54 (d, 1H); 13C NMR (100 MHz, DMSO-d6): δ6.6, 92.9, 146.6, 156.3, 166.1; mass spectrometry (ES+) ) analysis: calculated value C5H7N3O+ (M+H+) 126.0662, measured value 126.0804 confirmed.
References
[1] Kistenmacher, T. J.; Rossi, M. (1977-12-15). "1-Methylcytosine: a refinement". Acta Crystallographica (1977) Section B. 33 (12): 3962–3965.
[2] Hoshika S, et al. Hachimoji DNA and RNA: A genetic system with eight building blocks. Science. 2019 Feb 22;363(6429):884-887. DOI:10.1126/science.aat0971
1-METHYLCYTOSIN Preparation Products And Raw materials
1-METHYLCYTOSIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3991 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| NewCan Biotech Limited | +86-571-86912261 19975279805 | sales@newcanbio.com | China | 9985 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19956 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
View Lastest Price from 1-METHYLCYTOSIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-05-11 | 1-Methylcytosine
1122-47-0
|
$29.00 | 99.88% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-11 | 1-Methylcytosine
1122-47-0
|
$29.00 | 99.88% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-05-01 | 1-Methylcytosine
1122-47-0
|
$29.00 | 100% | 10g | TargetMol Chemicals Inc. |
-
- 1-Methylcytosine
1122-47-0
- $29.00
- 99.88%
- TargetMol Chemicals Inc.
-
- 1-Methylcytosine
1122-47-0
- $29.00
- 99.88%
- TargetMol Chemicals Inc.
-
- 1-Methylcytosine
1122-47-0
- $29.00
- 100%
- TargetMol Chemicals Inc.
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