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ChemicalBook >> CAS DataBase List >>5-METHOXY-1H-INDAZOLE

5-METHOXY-1H-INDAZOLE

CAS No.
94444-96-9
Chemical Name:
5-METHOXY-1H-INDAZOLE
Synonyms
1H-Indazole, 5-methoxy-;5-METHOXYINDAZOLE;5-METHOXY-1H-INDAZOLE;5-Methoxy-1H-indazole?New;5-Methoxy-1H-indazole ,97%;2,4-Imidazolidinedione,5-(3-bromophenyl)-7-methyl-
CBNumber:
CB5364336
Molecular Formula:
C8H8N2O
Molecular Weight:
148.16
MDL Number:
MFCD07781657
MOL File:
94444-96-9.mol
MSDS File:
SDS
Last updated:2026-05-28 01:27:49
Product description Number Pack Size Price
5-Methoxy-1H-indazole ≥95% OR110371 250mg $32
5-Methoxy-1H-indazole ≥95% OR110371 1g $112
5-Methoxyindazole 95% AS12288 1g $32
5-Methoxyindazole 95% AS12288 5g $95
5-Methoxyindazole 95% AS12288 25g $207
More product size

5-METHOXY-1H-INDAZOLE Properties

Melting point 167 °C(Solv: benzene (71-43-2))
Boiling point 312.5±15.0 °C(Predicted)
Density 1.244±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka 13.61±0.40(Predicted)
Appearance Light yellow to yellow Solid
InChI InChI=1S/C8H8N2O/c1-11-7-2-3-8-6(4-7)5-9-10-8/h2-5H,1H3,(H,9,10)
InChIKey GZWWDKIVVTXLFL-UHFFFAOYSA-N
SMILES N1C2=C(C=C(OC)C=C2)C=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Risk Statements  22-41
Safety Statements  26-39
HS Code  29339900

5-METHOXY-1H-INDAZOLE price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR110371 5-Methoxy-1H-indazole ≥95% 94444-96-9 250mg $32 2026-06-04 Buy
Apolloscientific OR110371 5-Methoxy-1H-indazole ≥95% 94444-96-9 1g $112 2026-06-04 Buy
Activate Scientific AS12288 5-Methoxyindazole 95% 94444-96-9 1g $32 2026-06-04 Buy
Activate Scientific AS12288 5-Methoxyindazole 95% 94444-96-9 5g $95 2026-06-04 Buy
Activate Scientific AS12288 5-Methoxyindazole 95% 94444-96-9 25g $207 2026-06-04 Buy
Product number Packaging Price Buy
OR110371 250mg $32 Buy
OR110371 1g $112 Buy
AS12288 1g $32 Buy
AS12288 5g $95 Buy
AS12288 25g $207 Buy

5-METHOXY-1H-INDAZOLE Chemical Properties,Uses,Production

Chemical Properties

Yellow solid

Synthesis

2-Methyl-4-methoxybenzenamine

102-50-1

5-METHOXY-1H-INDAZOLE

94444-96-9

General procedure for the synthesis of 5-methoxy-1H-indazole using 2-methyl-4-methoxyaniline as starting material: aqueous (8.1 ml) solution of sodium nitrite (3.38 g, 49.0 mmol) was slowly added dropwise to acetic acid (350 ml) solution of 4-methoxy-2-methylaniline (6.69 g, 48.8 mmol) under ice-water bath conditions. The temperature was strictly controlled not to exceed 25°C during the reaction, followed by continuous stirring at room temperature overnight. After completion of the reaction, the reaction mixture was poured into water and extracted with chloroform. The organic layers were combined, washed with saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure and the resulting crude product was purified by silica gel column chromatography (eluent ratio of chloroform/methanol=9/1) to give 5-methoxy-1H-indazole (1.30 g, 18% yield). The product was characterized by 1H-NMR (DMSO-d6) and the chemical shifts δ were 3.76 (3H, s), 6.98 (1H, dd, J=8.8,1.8 Hz), 7.15 (1H, d, J=1.8 Hz), 7.42 (1H, d, J=8.8 Hz), 7.93 (1H, s), and 12.89 (1H, brs).

References

[1] Patent: EP1403255, 2004, A1. Location in patent: Page 44
[2] Bulletin of the Chemical Society of Japan, 1985, vol. 58, # 1, p. 309 - 315
[3] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 23, p. 5293 - 5297
[4] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 9, p. 1153 - 1156
[5] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 8, p. 2410 - 2414

102-50-1
94444-96-9
Synthesis of 5-METHOXY-1H-INDAZOLE from 2-Methyl-4-methoxybenzenamine
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View Lastest Price from 5-METHOXY-1H-INDAZOLE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-METHOXY-1H-INDAZOLE pictures 2019-07-06 5-METHOXY-1H-INDAZOLE
94444-96-9
$8.80 1KG 97%-99% 100kg Career Henan Chemical Co

5-METHOXY-1H-INDAZOLE Spectrum

5-METHOXY-1H-INDAZOLE 5-METHOXYINDAZOLE 5-Methoxy-1H-indazole ,97% 2,4-Imidazolidinedione,5-(3-bromophenyl)-7-methyl- 5-Methoxy-1H-indazole?New 1H-Indazole, 5-methoxy- 94444-96-9 Indazoles
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