ENALAPRILAT DIHYDRATE
- CAS No.
- 84680-54-6
- Chemical Name:
- ENALAPRILAT DIHYDRATE
- Synonyms
- MK-422;ENALAPRILATE;as dihydrate;ENALAPRILAT USP;MK-422 Dihydrate;Enalaprilate USP25;Vasotec IV Dihydrate;Inapulla (dihydrate);Enalaprilat (300 mg);ENALAPRILAT DIHYDRATE
- CBNumber:
- CB5373019
- Molecular Formula:
- C18H26N2O6
- Molecular Weight:
- 366.41
- MDL Number:
- MFCD00941393
- MOL File:
- 84680-54-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Enalaprilat dihydrate European Pharmacopoeia (EP) Reference Standard | Y0000615 | 100 mg | $167 |
| Enalaprilat dihydrate ≥98% (HPLC) | E9658 | 5mg | $148 |
| Enalaprilat certified reference material, pharmaceutical secondary standard | PHR3440 | 500MG | $557 |
| Enalaprilat British Pharmacopoeia (BP) Reference Standard | BP742 | 20MG | $263 |
| Enalaprilat United States Pharmacopeia (USP) Reference Standard | 1235274 | 300mg | $538 |
| More product size | |||
| Melting point | 151-159°C |
|---|---|
| alpha | [α]D25 -53.0～-56.0゜ (c=1, CH3OH) (Calculated on dehydrous basis) |
| storage temp. | 2-8°C |
| solubility | H2O: soluble14mg/mL at 60°C (warming for 5 minutes) |
| form | Solid |
| color | White to Off-White |
| Water Solubility |
H2O: 14mg/mL at60°C (warming for 5 minutes) DMSO: 64mg/mL |
| InChIKey | MFNXXPRUKGSARH-MTPBSTKNNA-N |
| SMILES | C(N1CCC[C@H]1C(=O)O)(=O)[C@H](C)N[C@H](C(=O)O)CCC1C=CC=CC=1.O |&1:5,10,13,r| |
| CAS DataBase Reference | 84680-54-6(CAS DataBase Reference) |
| FDA UNII | GV0O7ES0R3 |
| EPA Substance Registry System | L-Proline, N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-, hydrate (1:2) (84680-54-6) |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TW3590600 | |||||||||
| HS Code | 2933995300 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
ENALAPRILAT DIHYDRATE price More Price(92)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0000615 | Enalaprilat dihydrate European Pharmacopoeia (EP) Reference Standard | 84680-54-6 | 100 mg | $167 | 2026-04-30 | Buy |
| Sigma-Aldrich | E9658 | Enalaprilat dihydrate ≥98% (HPLC) | 84680-54-6 | 5mg | $148 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR3440 | Enalaprilat certified reference material, pharmaceutical secondary standard | 84680-54-6 | 500MG | $557 | 2026-04-30 | Buy |
| Sigma-Aldrich | BP742 | Enalaprilat British Pharmacopoeia (BP) Reference Standard | 84680-54-6 | 20MG | $263 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1235274 | Enalaprilat United States Pharmacopeia (USP) Reference Standard | 84680-54-6 | 300mg | $538 | 2026-04-30 | Buy |
ENALAPRILAT DIHYDRATE Chemical Properties,Uses,Production
Description
Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange, driving hypertension. Enalaprilat is the active metabolite of enalapril , an ACE inhibitor with roles in the management of hypertension, congestive heart failure, myocardial infarction, and diabetic nephropathies.. Enalaprilat is esterified with ethanol to produce enalapril in order to enable oral activity and subsequently metabolized in vivo to the active form by various esterases. Enalaprilat is reported to inhibit ACE activity with an IC50 value of 5.8 nM in vitro.
Chemical Properties
White Solid
Uses
Active metabolite of Enalapril. A nonsulfhydryl dipeptide angiotensin converting enzyme (ACE) inhibitor. Enalapril EP Impurity C (Dihydrate).
Uses
anthelmintic
Definition
ChEBI: The dihydrate form of enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor that is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients wi h nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is administered by intravenous injection.
Biochem/physiol Actions
Enalapril, the ethyl ester ofenalaprilat exhibits slight pharmacological activity until it is hydrolyzed in the liver toenalaprilat. Enalaprilat, a IV form of an angiotensin-converting-enzyme inhibitor (ACE) prevents the transformation of angiotensin I to angiotensin II, a potent vasoconstrictor.
References
[1] PIERRE REDELINGHUYS EDWARD D S ALOYSIUS T NCHINDA. Development of Domain-Selective Angiotensin I-Converting Enzyme Inhibitors[J]. Annals of the New York Academy of Sciences, 2006, 1056 1: 160-175. DOI: 10.1196/annals.1352.035
[2] JAMES J. MENCEL. Angiotensin converting enzyme inhibitors. 10. Aryl sulfonamide substituted N-[1-carboxy-3-phenylpropyl]-L-alanyl-L-proline derivatives as novel antihypertensives[J]. Journal of Medicinal Chemistry, 1990, 33 6: 1606-1615. DOI: 10.1021/jm00168a013
ENALAPRILAT DIHYDRATE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| TopScience Biochemical | 00852-68527855 | info@itopbiochem.com | China Hong Kong | 902 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 21169 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15082 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9539 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 | info@fortunachem.com | China | 5983 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9414 | 58 |
View Lastest Price from ENALAPRILAT DIHYDRATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-08 | Enalaprilat Dihydrate
84680-54-6
|
1g | 98%-101% | 500G | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-04-21 | Enalaprilat Dihydrate
84680-54-6
|
$33.00-84.00 | 99.46% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-12-10 | Enalaprilat Dihydrate
84680-54-6
|
$850.00 | 1mg | 99 % | 500 Kg | R&D Scientific Inc. |
-
- Enalaprilat Dihydrate
84680-54-6
- $0.00
- 98%-101%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Enalaprilat Dihydrate
84680-54-6
- $33.00-84.00
- 99.46%
- TargetMol Chemicals Inc.
-
- Enalaprilat Dihydrate
84680-54-6
- $850.00
- 99 %
- R&D Scientific Inc.
