Trichlormethiazide
- CAS No.
- 133-67-5
- Chemical Name:
- Trichlormethiazide
- Synonyms
- TRICLORMETIAZIDA;TRICHLOROMETHIAZIDE;Naqua;Flurese;Naquival;Metahydrin;Navis;Nydor;Nakva;Natril
- CBNumber:
- CB5407444
- Molecular Formula:
- C8H8Cl3N3O4S2
- Molecular Weight:
- 380.66
- MDL Number:
- MFCD00057315
- MOL File:
- 133-67-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Trichlormethiazide United States Pharmacopeia (USP) Reference Standard | 1681000 | 200mg | $400 |
| Trichloromethiazide >99.0%(T) | T1318 | 10g | $149 |
| Trichlormethiazide ≥98% | 29331 | 1g | $36 |
| Trichlormethiazide ≥98% | 29331 | 5g | $120 |
| Trichlormethiazide ≥98% | 29331 | 10g | $186 |
| More product size | |||
| Melting point | 248-250℃ |
|---|---|
| Boiling point | 631.3±65.0 °C(Predicted) |
| Density | 1.748 |
| refractive index | 1.6000 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | pKa 6.9(acetone/H2O) (Uncertain) |
| color | White to Off-White |
| Merck | 14,9624 |
| Major Application | pharmaceutical (small molecule) |
| InChI | 1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16) |
| InChIKey | LMJSLTNSBFUCMU-UHFFFAOYSA-N |
| SMILES | NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C(Cl)Cl)cc1Cl |
| CAS DataBase Reference | 133-67-5(CAS DataBase Reference) |
| FDA UNII | Q58C92TUN0 |
| ATC code | C03AA06 |
| EPA Substance Registry System | Trichlormethiazide (133-67-5) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H317-H334 | |||||||||
| Precautionary statements | P261-P272-P280-P284-P302+P352-P304+P340+P312 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 42/43 | |||||||||
| Safety Statements | 36 | |||||||||
| RIDADR | UN2811 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | DK8925000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| HS Code | 2935904000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Resp. Sens. 1 Skin Sens. 1 |
|||||||||
| Hazardous Substances Data | 133-67-5(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 orally in rats: >20000 mg/kg (Goldenthal) | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Trichlormethiazide price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1681000 | Trichlormethiazide United States Pharmacopeia (USP) Reference Standard | 133-67-5 | 200mg | $400 | 2026-04-30 | Buy |
| TCI Chemical | T1318 | Trichloromethiazide >99.0%(T) | 133-67-5 | 10g | $149 | 2026-04-30 | Buy |
| Cayman Chemical | 29331 | Trichlormethiazide ≥98% | 133-67-5 | 1g | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 29331 | Trichlormethiazide ≥98% | 133-67-5 | 5g | $120 | 2026-04-30 | Buy |
| Cayman Chemical | 29331 | Trichlormethiazide ≥98% | 133-67-5 | 10g | $186 | 2026-04-30 | Buy |
Trichlormethiazide Chemical Properties,Uses,Production
Chemical Properties
Trichlormethiazide occurs as a white or practically white, crystalline powder and may have a slight characteristic odor.
Originator
Naqua,Schering,US,1960
Uses
diuretic, antihypertensive
Uses
Trichlormethiazide, is a diuretic, having similar properties as Hydrochlorothiazide (H714560). It is used for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension.
Uses
Trichlormethiazide is a diuretic and anti-hypertensive agent from the benzothiadiazide class which is used in veterinary medicine in cattle, sheep, goats, pigs and horses, at the following therapeutic regimen: a single intramuscular dose of 0.4 mg/kg bw followed by two oral doses of 0.8 mg/kg bw given 12 and 36 hours after the first administration.
Trichlormethiazide is also used in humans in the United States as a diuretic and anti-hypertensive substance but not in the European Union. The usual dose is 2 to 4 mg twice a day (i.e. approximately 0.033 to 0.066 mg/kg bw/day).
Definition
ChEBI: Trichlormethiazide is a benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension. It has a role as a diuretic and an antihypertensive agent. It is a benzothiadiazine and a sulfonamide antibiotic.
Manufacturing Process
A mixture of 5.7 grams (0.02 mol) of 5-chloro-2,4-disulfamylaniline and 4.9 grams (0.04 mol) of dichloroacetaldehyde in 25 ml of dimethyl formamide was heated at the boiling temperature and under reflux for 30 minutes. The reaction mixture was thereafter poured into a mixture of ice and water to precipitate the desired 6-chloro-7-sulfamyl-3-dichloromethyl-3,4-dihydro- 1,2,4-benzothiadiazine-1,1-dioxide as a crystalline solid melting at 250° to 270°C with decomposition.
Therapeutic Function
Diuretic
Trichlormethiazide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Suzhou Sanyi Polymer Chemical Technology Co., Ltd. | +8615571922873 | 15571922873@163.com | China | 102 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Taixing Foreign Trade Nanjing Co., Ltd. | +86-025-83346564; +8613182976929 | sales@tx-chem.com | China | 125 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Shaanxi Franta Biotechnology Co., Ltd | +86-13082019107 | admin@flanderff.com | China | 244 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Hebei Runbin Biotechnology Co. LTD | 13180553332 | 2179877681@qq.com | CHINA | 990 | 58 |
View Lastest Price from Trichlormethiazide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Trichlormethiazide
133-67-5
|
$33.00 | 99.54% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-04-22 | Trichlormethiazide
133-67-5
|
$33.00 | 99.54% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-01-14 | Trichlormethiazide
133-67-5
|
25kg | 98.0% | 2000kg | Taixing Foreign Trade Nanjing Co., Ltd. |
-
- Trichlormethiazide
133-67-5
- $33.00
- 99.54%
- TargetMol Chemicals Inc.
-
- Trichlormethiazide
133-67-5
- $33.00
- 99.54%
- TargetMol Chemicals Inc.
-
- Trichlormethiazide
133-67-5
- $0.00
- 98.0%
- Taixing Foreign Trade Nanjing Co., Ltd.
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