2-CHLORO-5-NITROPYRIMIDIN-4-AMINE
- CAS No.
- 1920-66-7
- Chemical Name:
- 2-CHLORO-5-NITROPYRIMIDIN-4-AMINE
- Synonyms
- 4-AMINO-2-CHLORO-5-NITROPYRIMIDINE;KML-51;IFLAB-BB F1930-0037;nitropyrimidin-1-(2-prop-2-enoxyethoxy)butane;2-CHLORO-5-NITRO-4-PYRIMIDINAMINE;2-CHLORO-5-NITROPYRIMIDIN-4-AMINE;2-Chloro-5-nitropirimidin-4-amine;2-Chloro-5-nitropyrimidine-4-amine;2-Chloro-5-nitro-6-aminopyrimidine
- CBNumber:
- CB5468616
- Molecular Formula:
- C4H3ClN4O2
- Molecular Weight:
- 174.55
- MDL Number:
- MFCD00127771
- MOL File:
- 1920-66-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Amino-2-chloro-5-nitropyrimidine 95% | 720321 | 1g | $211 |
| 4-Amino-2-chloro-5-nitropyrimidine 95% | 720321 | 250mg | $74 |
| 4-Amino-2-chloro-5-nitropyrimidine 96% | OR471127 | 250mg | $21 |
| 4-Amino-2-chloro-5-nitropyrimidine 96% | OR471127 | 1g | $25 |
| 4-Amino-2-chloro-5-nitropyrimidine 96% | OR471127 | 5g | $116 |
| More product size | |||
| Melting point | 221-226 °C |
|---|---|
| Boiling point | 446.0±25.0 °C(Predicted) |
| Density | 1.712±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | -1.22±0.10(Predicted) |
| form | Solid |
| Appearance | Light yellow to yellow Solid |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C4H3ClN4O2/c5-4-7-1-2(9(10)11)3(6)8-4/h1H,(H2,6,7,8) |
| InChIKey | RZGOEIWDMVQJBQ-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=C([N+]([O-])=O)C(N)=N1 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H319-H334-H335 | |||||||||
| Precautionary statements | P301+P312+P330-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38-43 | |||||||||
| Safety Statements | 26-36/37-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Resp. Sens. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-CHLORO-5-NITROPYRIMIDIN-4-AMINE price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 720321 | 4-Amino-2-chloro-5-nitropyrimidine 95% | 1920-66-7 | 1g | $211 | 2023-01-07 | Buy |
| Sigma-Aldrich | 720321 | 4-Amino-2-chloro-5-nitropyrimidine 95% | 1920-66-7 | 250mg | $74 | 2022-05-15 | Buy |
| Apolloscientific | OR471127 | 4-Amino-2-chloro-5-nitropyrimidine 96% | 1920-66-7 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR471127 | 4-Amino-2-chloro-5-nitropyrimidine 96% | 1920-66-7 | 1g | $25 | 2026-06-04 | Buy |
| Apolloscientific | OR471127 | 4-Amino-2-chloro-5-nitropyrimidine 96% | 1920-66-7 | 5g | $116 | 2026-06-04 | Buy |
2-CHLORO-5-NITROPYRIMIDIN-4-AMINE Chemical Properties,Uses,Production
Chemical Properties
Yellow to brown solid
Uses
It is an important raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.
Synthesis
49845-33-2
1920-66-7
General procedure for the synthesis of 2-chloro-4-amino-5-nitropyrimidines from 2,4-dichloro-5-nitropyrimidines: a solution of 2,4-dichloro-5-nitropyrimidines (30 g, 154.36 mmol) was slowly added dropwise to a solution of 2,4-dichloro-5-nitropyrimidines (30 g, 154.36 mmol) in dichloromethane (DCM) with ammonia (NH3-H2O, aqueous solution, 24 mL) and N,N-diisopropylethylamine ( DIPEA, 37.2 mL) to a mixed solution of DCM (400 mL). The reaction mixture was stirred continuously at 0 °C for 1 h, followed by filtration. The collected solid was dried to give the target product 2-chloro-4-amino-5-nitropyrimidine (25 g, 92.6% yield) as a yellow solid. It was analyzed by liquid chromatography-mass spectrometry (LCMS, ESI) and m/z: 175.0 ([M+H]+) was measured.
References
[1] Patent: US2017/313683, 2017, A1. Location in patent: Paragraph 0541-0542
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 23, p. 10685 - 10699
[3] Patent: EP2578584, 2013, A1. Location in patent: Paragraph 0071; 0072
[4] Journal of Heterocyclic Chemistry, 2012, vol. 49, # 2, p. 321 - 328
[5] Patent: EP3284743, 2018, A1. Location in patent: Paragraph 0135
2-CHLORO-5-NITROPYRIMIDIN-4-AMINE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| KARMEL TECHNOLOGY (HK) CO.,LIMITED | +8618795957998 | karmelhk@126.com | CHINA | 2886 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20725 | 58 |
View Lastest Price from 2-CHLORO-5-NITROPYRIMIDIN-4-AMINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-11-18 | 2-CHLORO-5-NITROPYRIMIDIN-4-AMINE
1920-66-7
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-01-09 | 2-CHLORO-5-NITROPYRIMIDIN-4-AMINE
1920-66-7
|
$6.68 | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- 2-CHLORO-5-NITROPYRIMIDIN-4-AMINE
1920-66-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-CHLORO-5-NITROPYRIMIDIN-4-AMINE
1920-66-7
- $6.68
- 97%-99%
- Career Henan Chemical Co
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