HUWENTOXIN IV
- CAS No.
- 526224-73-7
- Chemical Name:
- HUWENTOXIN IV
- Synonyms
- HUWENTOXIN IV;HUWENTOXIN IV USP/EP/BP
- CBNumber:
- CB54730704
- Molecular Formula:
- C174H278N52O51S6
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Huwentoxin IV Asreported | 255471 | 100ug | $495 |
| Huwentoxin- IV | PCB-4455-S | 0.1mg | $1042.87 |
| Huwentoxin IV | BWA22473 | 1mg | $3905.4 |
| Huwentoxin IV | B5693 | 100ug | $356 |
| HuwentoxinIV | 4718 | 100U | $220 |
HUWENTOXIN IV price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 255471 | Huwentoxin IV Asreported | 526224-73-7 | 100ug | $495 | 2026-06-03 | Buy |
| Biosynth | PCB-4455-S | Huwentoxin- IV | 0.1mg | $1042.87 | 2026-06-04 | Buy | |
| Biosynth | BWA22473 | Huwentoxin IV | 526224-73-7 | 1mg | $3905.4 | 2026-06-04 | Buy |
| ApexBio Technology | B5693 | Huwentoxin IV | 526224-73-7 | 100ug | $356 | 2026-05-06 | Buy |
| Tocris | 4718 | HuwentoxinIV | 526224-73-7 | 100U | $220 | 2021-12-16 | Buy |
HUWENTOXIN IV Chemical Properties,Uses,Production
Uses
Huwentoxin-IV is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC50s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV has analgesic effects on animal models of inflammatory and neuropathic pain[1][2].
IC 50
Nav1.7: 26 nM (IC50); Nav1.3: 338 nM (IC50); Nav1.4: 400 nM (IC50); Nav1.2: 150 nM (IC50)
References
[1] Xiao Y, et, al. Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration. J Biol Chem. 2008 Oct 3;283(40):27300-13. DOI:10.1074/jbc.M708447200
[2] Liu Y, et, al. Analgesic effects of Huwentoxin-IV on animal models of inflammatory and neuropathic pain. Protein Pept Lett. 2014; 21(2): 153-8. DOI:10.2174/09298665113206660119
HUWENTOXIN IV Preparation Products And Raw materials
Raw materials
Preparation Products
HUWENTOXIN IV Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 21157 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| Changsha MOL Changes Biotechnology Co., Ltd. | +8619375158599 | info@molchanges.com | China | 5218 | 58 |
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +8613382787392 | sales@aeechem.com | China | 10001 | 58 |
| Creative Peptides | info@creative-peptides.com | United States | 6083 | 56 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89686 | 60 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 +86-17380623303; | Caroline@youngshechem.com | China | 4801 | 58 |
