4-(Trifluoromethoxy)benzonitrile
- CAS No.
- 332-25-2
- Chemical Name:
- 4-(Trifluoromethoxy)benzonitrile
- Synonyms
- uoromethoxy)benzonitriL;p-trifluoromethoxybenonitrile;p-Cyanotrifluoromethoxybenzene;4-(Trifluoromethoxy)benzonitrile;4-(Trifluoromethoxy)cyanobenzene;4-(Trifluoromethyloxy)benzonitrile;Benzonitrile, 4-(trifluoromethoxy)-;4-(Trifluoromethoxy)benzonitrile 98%;4-(TRIFLUOROMETHOXY)BENZONITRILE 98;For trifluoromethoxy benzene nitrile
- CBNumber:
- CB5499137
- Molecular Formula:
- C8H4F3NO
- Molecular Weight:
- 187.12
- MDL Number:
- MFCD00039474
- MOL File:
- 332-25-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-(Trifluoromethoxy)benzonitrile >98.0%(GC) | T2292 | 1g | $22 |
| 4-(Trifluoromethoxy)benzonitrile >98.0%(GC) | T2292 | 5g | $36 |
| 4-(Trifluoromethoxy)benzonitrile 98% | PC7438G | 25g | $21 |
| 4-(Trifluoromethoxy)benzonitrile 98% | PC7438G | 100g | $74 |
| 4-(Trifluoromethoxy)benzonitrile 98% | PC7438G | 500g | $226 |
| More product size | |||
| Boiling point | 192-193 °C(lit.) |
|---|---|
| Density | 1.285 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 181 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| form | clear liquid |
| color | Colorless to Almost colorless |
| BRN | 2832939 |
| InChI | InChI=1S/C8H4F3NO/c9-8(10,11)13-7-3-1-6(5-12)2-4-7/h1-4H |
| InChIKey | XWHIXOMWXCHJPP-UHFFFAOYSA-N |
| SMILES | C(#N)C1=CC=C(OC(F)(F)F)C=C1 |
| CAS DataBase Reference | 332-25-2(CAS DataBase Reference) |
| EPA Substance Registry System | Benzonitrile, 4-(trifluoromethoxy)- (332-25-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H315-H319-H332-H335-H227-H331 | |||||||||
| Precautionary statements | P210e-P405-P501a-P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,T,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | 3276 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Toxic | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29269090 | |||||||||
| NFPA 704 |
|
4-(Trifluoromethoxy)benzonitrile price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T2292 | 4-(Trifluoromethoxy)benzonitrile >98.0%(GC) | 332-25-2 | 1g | $22 | 2026-04-30 | Buy |
| TCI Chemical | T2292 | 4-(Trifluoromethoxy)benzonitrile >98.0%(GC) | 332-25-2 | 5g | $36 | 2026-04-30 | Buy |
| Apolloscientific | PC7438G | 4-(Trifluoromethoxy)benzonitrile 98% | 332-25-2 | 25g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC7438G | 4-(Trifluoromethoxy)benzonitrile 98% | 332-25-2 | 100g | $74 | 2026-06-04 | Buy |
| Apolloscientific | PC7438G | 4-(Trifluoromethoxy)benzonitrile 98% | 332-25-2 | 500g | $226 | 2026-06-04 | Buy |
4-(Trifluoromethoxy)benzonitrile Chemical Properties,Uses,Production
Chemical Properties
clear light yellow liquid
General Description
4-(Trifluoromethoxy)benzonitrile serves as an intermediate in the synthesis of fluvoxamine.
Synthesis
1736-74-9
332-25-2
To a 25 mL Schlenk tube equipped with a magnetic stirrer were sequentially added CuCl (0.05 mmol, 5 mol%), DABCO (0.10 mmol, 10 mol%) and 4-HO-TEMPO (0.05 mmol, 5 mol%). Subsequently, a solution of acetonitrile (2 mL) with 4-trifluoromethoxybenzyl alcohol (1 mmol) and ammonia (25-28%, 3 mmol, 3.0 equiv) was added. The reaction mixture was stirred at room temperature for 24 h under balloon protection. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was diluted with water and extracted with ethyl acetate. The organic layers were combined and dried with anhydrous magnesium sulfate. After concentration under reduced pressure, the crude product was purified by column chromatography to give p-trifluoromethoxybenzonitrile.
References
[1] Advanced Synthesis and Catalysis, 2014, vol. 356, # 18, p. 3892 - 3896
[2] Chinese Chemical Letters, 2018, vol. 29, # 3, p. 464 - 466
4-(Trifluoromethoxy)benzonitrile Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Shanghai Safer Pharmaceutical Technology Co., Ltd. | 021-31761238 | sales@saferph.com | CHINA | 897 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from 4-(Trifluoromethoxy)benzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 4-(Trifluoromethoxy)benzonitrile
332-25-2
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 4-(Trifluoromethoxy)benzonitrile
332-25-2
- $1.00
- 99%
- Career Henan Chemical Co
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